Results 111 to 120 of about 22,957,653 (345)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Sharp Results and Fluid Flow Applications for a Specific Class of Meromorphic Functions Introduced by a New Operator

Axioms
In this investigation, we introduce a new meromorphic operator defined by meromorphic univalent functions. A new class of meromorphic functions is introduced by this operator, which can generate several distinct subclasses depending on the values of its ...
Aya F. Elkhatib, Atef F. Hashem, Adela O. Mostafa, Mohammed M. Tharwat   +3 more
doaj   +1 more source

Spontaneous Symmetry Breaking and Proper-Time Flow Equations

, 2004
We discuss the phenomenon of spontaneous symmetry breaking by means of a class of non-perturbative renormalization group flow equations which employ a regulating smearing function in the proper-time integration. We show, both analytically and numerically,
Alexandre, Alfio Bonanno, Ames, Ardekani, Berges, Bohr, Bonanno, Bonini, Floreanini, Giuseppe Lacagnina, Hemmer, Liao, Liao, Liao, Litim, Litim, Litim, Litim, Litim, Litim, Mazza, Meyer, Montvay, Morris, O'Raifeartaigh, O'Raifeartaigh, Oleszczuk, Oleszczuk, Papp, Parola, Parola, Parola, Parola, Parola, Ringwald, Schäfer, Schäfer, Shepard, Tetradis, Wegner, Weinberg, Wetterich, Wilson, Wilson, Zappalà, Zappalà   +45 more
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Wake flow past a submerged plate near a free surface

European Journal of Applied Mathematics
A wake model is pursued for potential flow past a submerged, finite-length plate that is perpendicular to a uniform, horizontal stream bounded above by a free surface. The effects of gravity are included along the free surface.
E. McLean, Robert Bowles, Jean-Marc Vanden-Broeck   +2 more
doaj   +1 more source

Application of the AMI C sub l sub max prediction method to a number of airfoils [PDF]

A method for calculating the flow about airfoils up to and beyond the stall is described. It is an iterative procedure between potential flow and boundary layer solutions.
Dvorak, F. A., Maskew, B.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Analysis of streaming potential flow and electroviscous effect in a shear-driven charged slit microchannel. [PDF]

Sci Rep, 2020
Riad A, Khorshidi B, Sadrzadeh M.
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source