Results 51 to 60 of about 374 (253)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Advanced Science, EarlyView.The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt +16 more
wiley +1 more source
GestCO2 -Mesurage des concentrations en dioxyde de carbone en bâtiment de poulets de chair.
, 2022 L’arrêté ministériel du 28 juin 2010 établissant les normes relatives à la protection des poulets de chair, fixe une limite de 3000 ppm de dioxyde de carbone (CO2) à ne pas dépasser dans l’air à hauteur des animaux et sur toute la durée du lot. Depuis, les capteurs de concentrations en CO2 se développent en bâtiment avicole, ce gaz étant un bon ...
Creach, Pauline +7 more
openaire +3 more sources
Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Advanced Science, EarlyView.Schematic diagrams illustrating the breakthrough in the screening of AChE inhibitors from LBL, and the research process of the pharmacodynamics of the NCP are presented. ABSTRACT Current Alzheimer's drugs exhibit limited effectiveness, highlighting the necessity for multi‐target treatments.
Yuping Sa +11 more
wiley +1 more source
INRAE Productions AnimalesEn moins de 20 ans, Enterococcus cecorum est devenu l’un des agents pathogènes majeurs dans les élevages de poulets de chair et de répartition mondiale.
Rozenn SOUILLARD +4 more
doaj +1 more source
INRAE Productions Animales, 2000 Plusieurs modèles de simulation de réponse aux teneurs des aliments en acides aminés ou protéines, ainsi que d’estimation des besoins sont décrits et appliqués à trois productions : le poulet de chair en croissance, le canard de Barbarie en ...
B. LECLERCQ, C. BEAUMONT
doaj +1 more source
Advanced Science, EarlyView.A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen +5 more
wiley +1 more source
Histopathology of infectious bursal disease in non-lymphoid organs of chickens
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 1985 Un élevage de poulets de chair a été infecté avec le virus de la maladie de Gumboro (IBD) isolé au Nigéria. Quelques cas de pycnose sur des cellules épithéliales des tubes urinifères et des canalicules ont été observés sur des poulets sacrifiés 1 et 2 ...
J.O.A. Okoye
doaj +1 more source
Agribusiness, EarlyView.ABSTRACT The Cordillera Administrative Region in the Philippines is home to terraced rice embedded in centuries of cultural heritage. However, weak market incentives threaten sustained production, jeopardizing indigenous communities' cultural heritage and the in situ biodiversity of rice genetic resources.
Kofi Britwum, Matty Demont
wiley +1 more source