Results 61 to 70 of about 40,854 (262)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Design and Model-Based Evaluation of Active Clamping for Solid-State Circuit Breakers in Vehicular Power Supply Systems

IEEE Open Journal of Power Electronics
Solid-state circuit breakers, in vehicles also known as electronic fuses, isolate faults faster than conventional blade fuses and offer advanced protection mechanisms.
Bastian Eisenmann, Martin Baumann, Christoph Mayer, Marcelo Lobo Heldwein   +3 more
doaj   +1 more source

An Overview of Applications of the Modular Multilevel Matrix Converter

Energies, 2020
The modular multilevel matrix converter is a relatively new power converter topology suitable for high-power alternating current (AC)-to-AC applications.
Matias Diaz, Roberto Cárdenas Dobson, Efrain Ibaceta, Andrés Mora, Matias Urrutia, Mauricio Espinoza, Felix Rojas, Patrick Wheeler   +7 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Generalized Parametric Design of an Integrated Electric Vehicle Drive System for Wide-Speed-Range Operation: Experimental Validation, Torque Control, and Performance Assessment

IEEE Access
Existing research on electric vehicles (EVs) predominantly addresses component sizing for the electric vehicle drivetrain system (EVDS) without adequate validation of dynamic performance under integrated traction motor (TM) control.
Mahmoud M. Akl, Jose Rodriguez, Mohamed Abdelrahem, Abdelsalam A. Ahmed   +3 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Enhanced Modulated Model Predictive Control for Matrix Converters in Overmodulation Zones

IEEE Open Journal of Power Electronics
Modulated Model Predictive Control (MMPC) techniques can be applied to enhance matrix converter (MC) performance in the linear modulation zone (LMZ). However, extending the converter operation in the overmodulation zone (OMZ) remains a problem.
Ali Sarajian, Quanxue Guan, Ibrahim Harbi, Davood Arab Khaburi, Ralph Kennel, Cristian Garcia, Patrick Wheeler, Jose Rodriguez   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source