Results 91 to 100 of about 31,022 (291)
Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy [PDF]
, 2014 BACKGROUND: PROSTVAC®, an active immunotherapy currently studied for the treatment of metastatic castration-resistant prostate cancer (mCRPC), consists of a heterologous prime-boost regimen with two different poxvirus-based vectors to provoke productive ...
Alain Delcayre +8 more
core +2 more sources
Advanced Science, Volume 12, Issue 42, November 13, 2025.Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu +12 more
wiley +1 more source
Poxvirus DNA Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2013 Poxviruses are large, enveloped viruses that replicate in the cytoplasm and encode proteins for DNA replication and gene expression. Hairpin ends link the two strands of the linear, double-stranded DNA genome. Viral proteins involved in DNA synthesis include a 117-kDa polymerase, a helicase-primase, a uracil DNA glycosylase, a processivity factor, a ...
openaire +2 more sources
Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]
, 2015 Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio +2 more
core +1 more source
Hypsugopoxvirus: A Novel Poxvirus Isolated from Hypsugo savii in Italy
Viruses, 2019 Interest in bat-related viruses has increased considerably during the last decade, leading to the discovery of a rising number of new viruses in several bat species.
D. Lelli +11 more
semanticscholar +1 more source
Breaking barriers: The cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, Volume 45, Issue 11, Page 1513-1546, November 2025.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
Persistence of Protective Immunity to Malaria Induced by DNA Priming and Poxvirus Boosting: Characterization of Effector and Memory CD8+-T-Cell Populations [PDF]
, 2002 The persistence of immunity to malaria induced in mice by a heterologous DNA priming and poxvirus boosting regimen was characterized. Mice were immunized by priming with DNA vaccine plasmids encoding the Plasmodium yoelii circumsporozoite protein (PyCSP)
Belmonte, Arnel +11 more
core +2 more sources
Ecography, Volume 2025, Issue 11, November 2025.Hawaii has experienced profound declines in native avifauna alongside the introduction of numerous bird species. While site‐specific population studies are common, landscape‐level analyses of avian population dynamics are rare, particularly in island ecosystems. To address this gap, we used a density surface model to create a spatio‐temporal projection
Trevor Bak +5 more
wiley +1 more source
Trans-kingdom mimicry underlies ribosome customization by a poxvirus kinase
Nature, 2017 Ribosomes have the capacity to selectively control translation through changes in their composition that enable recognition of specific RNA elements.
Sujata Jha +8 more
semanticscholar +1 more source
Changes in HIV‐1 Reservoir Dynamics After Mpox Infection
Journal of Medical Virology, Volume 97, Issue 11, November 2025.ABSTRACT In May 2022, a large outbreak of monkeypox virus (MPXV) occurred in several non‐endemic regions worldwide. Another outbreak in 2024 raised global concerns, particularly for immunocompromised individuals like people with HIV (PWH). Since the latent HIV‐1 reservoir remains a major barrier to a cure, we investigated how past mpox infection ...
Guiomar Casado‐Fernández +14 more
wiley +1 more source