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Emerging interplays between poxviruses and autophagy [PDF]
Frontiers in Cellular and Infection MicrobiologyPoxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm. Their life cycle is closely associated with various membrane-related cellular processes.
Yongge Li +4 more
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TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository [PDF]
ProteomesBackground: Poxviruses constitute a family of large dsDNA viruses that can infect a plethora of species including humans. Historically, poxviruses have caused a health burden in multiple outbreaks.
Mansi Dutt +4 more
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Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park +6 more
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Why do poxviruses still matter?
Cell & Bioscience, 2021 Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public health concerns and serious endemic diseases ...
Zhilong Yang, Mark Gray, Lake Winter
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Pathogens, 2021 Following the WHO announcement of smallpox eradication, discontinuation of smallpox vaccination with vaccinia virus (VACV) was recommended. However, interest in VACV was soon renewed due to the opportunity of genetic engineering of the viral genome by ...
Sergei N. Shchelkunov +4 more
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Pharmaceuticals, 2022 Monkeypox is a zoonotic contagious disease that has recently re-emerged in different countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there is an urgent need to find effective drugs to stop the spread of the multi-
Hisham N. Altayb
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Annual Review of Virology, 2014 Current standard treatments of cancer can prolong survival of many cancer patients but usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic for the treatment of cancer that exploits replication-competent viruses to selectively infect and destroy cancerous cells while sparing normal cells and tissues.
Winnie M, Chan, Grant, McFadden
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Биопрепараты: Профилактика, диагностика, лечение, 2021 The main triggers of new infectious diseases, including those with pandemic potential, are: spontaneous emergence of infectious strains which are more virulent for humans and contribute to transmission of pathogenic microorganisms, environmental changes,
G. G. Onishchenko +3 more
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Cowpox Viruses: A Zoo Full of Viral Diversity and Lurking Threats
Biomolecules, 2023 Cowpox viruses (CPXVs) exhibit the broadest known host range among the Poxviridae family and have caused lethal outbreaks in various zoo animals and pets across 12 Eurasian countries, as well as an increasing number of human cases.
Ryan C. Bruneau +2 more
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Viruses, 2022 Cetacean poxviruses (CePVs) cause ‘tattoo’ skin lesions in small and large cetaceans worldwide. Although the disease has been known for decades, genomic data for these poxviruses are very limited, with the exception of CePV-Tursiops aduncus, which was ...
Léa Luciani +4 more
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