Results 1 to 10 of about 14,853 (241)
TCEPVDB: Artificial Intelligence-Based Proteome-Wide Screening of Antigens and Linear T-Cell Epitopes in the Poxviruses and the Development of a Repository [PDF]
ProteomesBackground: Poxviruses constitute a family of large dsDNA viruses that can infect a plethora of species including humans. Historically, poxviruses have caused a health burden in multiple outbreaks.
Mansi Dutt +4 more
doaj +3 more sources
The silent spread: uncovering the diversity and evolution of poxviruses in ticks across Western China’s host landscapes [PDF]
Virology JournalBackground Poxviruses are a diverse group of pathogens with significant implications for both human and animal health. Ticks, as hematophagous arthropods, are capable of switching hosts during their life cycle.
Yuxi Wang +10 more
doaj +4 more sources
Annual Review of Virology, 2014 Current standard treatments of cancer can prolong survival of many cancer patients but usually do not effectively cure the disease. Oncolytic virotherapy is an emerging therapeutic for the treatment of cancer that exploits replication-competent viruses to selectively infect and destroy cancerous cells while sparing normal cells and tissues.
Winnie M, Chan, Grant, McFadden
openaire +4 more sources
Why do poxviruses still matter? [PDF]
Cell & Bioscience, 2021 Poxviruses comprise many members that infect both vertebrate and invertebrate animals, including humans. Despite the eradication of the historically notorious smallpox, poxviruses remain significant public health concerns and serious endemic diseases ...
Zhilong Yang, Mark Gray, Lake Winter
doaj +2 more sources
Emerging interplays between poxviruses and autophagy [PDF]
Frontiers in Cellular and Infection MicrobiologyPoxviruses are large double-stranded DNA viruses that replicate exclusively in the cytoplasm. Their life cycle is closely associated with various membrane-related cellular processes.
Yongge Li +4 more
doaj +2 more sources
Molecular Determinants of Species-Specific Interactions Between Protein Kinase R and Poxvirus K3 Orthologs [PDF]
VirusesProtein kinase R (PKR) is an antiviral protein that is involved in molecular “arms races” with viral antagonists. As a result, some PKR inhibitors, including the vaccinia virus (VACV) protein K3 and its orthologs from other poxviruses only inhibit PKRs ...
Chorong Park +6 more
doaj +2 more sources
Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species [PDF]
VaccinesBackground: Protein kinase R (PKR) inhibits general mRNA translation by phosphorylating the alpha subunit of eukaryotic translation initiation factor 2 (eIF2).
Huibin Yu +6 more
doaj +2 more sources
Worldwide Phylogenetic Relationship of Avian Poxviruses [PDF]
, 2013 Blanco, JM +19 more
core +3 more sources
Pathogens, 2021 Following the WHO announcement of smallpox eradication, discontinuation of smallpox vaccination with vaccinia virus (VACV) was recommended. However, interest in VACV was soon renewed due to the opportunity of genetic engineering of the viral genome by ...
Sergei N. Shchelkunov +4 more
doaj +1 more source
Pharmaceuticals, 2022 Monkeypox is a zoonotic contagious disease that has recently re-emerged in different countries worldwide. Due to the lack of an effective treatment that eliminates the virus, there is an urgent need to find effective drugs to stop the spread of the multi-
Hisham N. Altayb
doaj +1 more source