Results 21 to 30 of about 14,001 (196)

Poxviruses Utilize Multiple Strategies to Inhibit Apoptosis

Viruses, 2017
Cells have multiple means to induce apoptosis in response to viral infection. Poxviruses must prevent activation of cellular apoptosis to ensure successful replication. These viruses devote a substantial portion of their genome to immune evasion. Many of
Daniel Brian Nichols, William De Martini, Jessica Cottrell   +2 more
doaj   +1 more source

Monkeypox: A Little-Studied Biological Threat to Russia

Вестник войск РХБ защиты, 2023
Monkeypox is a natural focal zoonosis of rodents and monkeys living in the Congo Valley (clade CB) and West Africa (clade WA). The special interest in monkeypox is due to its pandemic spread, which began in May 2022.
M. V. Supotnitskiy
doaj   +1 more source

Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion

Biomedicines, 2021
Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs), which are molecular signatures shared by different pathogens.
Huibin Yu, Ryan C. Bruneau, Greg Brennan, Stefan Rothenburg   +3 more
doaj   +1 more source

Inflammasomes: caspase-1-activating platforms with critical roles in host defense [PDF]

, 2011
Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes plays a critical role in the host response to microbial infections.
Lieselotte eVande Walle, Lieselotte eVande Walle, Mohamed eLamkanfi, Mohamed eLamkanfi   +3 more
core   +2 more sources

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Crocodilepox Virus Protein 157 Is an Independently Evolved Inhibitor of Protein Kinase R

Viruses, 2022
Crocodilepox virus (CRV) belongs to the Poxviridae family and mainly infects hatchling and juvenile Nile crocodiles. Most poxviruses encode inhibitors of the host antiviral protein kinase R (PKR), which is activated by viral double-stranded (ds) RNA ...
M. Julhasur Rahman, Loubna Tazi, Sherry L. Haller, Stefan Rothenburg   +3 more
doaj   +1 more source

The extraordinary evolutionary history of the reticuloendotheliosis viruses [PDF]

, 2013
The reticuloendotheliosis viruses (REVs) comprise several closely related amphotropic retroviruses isolated from birds. These viruses exhibit several highly unusual characteristics that have not so far been adequately explained, including their extremely
A Katzourakis, A Katzourakis, A Stamatakis, AC van der Kuyl, AD Yoder, AL Hughes, AM Awad, AM Fadly, Anna Maria Niewiadomska, Bill Sugden, BR Burmester, C Feschotte, C Hertig, CG Ludford, CG Ludford, CN Dren, CN Dren, CN Dren, CR Parrish, CY Kang, CY Lin, DC Nickle, DH Huson, DH Ley, DJ McGeoch, DS Arathy, DW Trampel, E Prukner-Radovcic, EH Dearborn, F Abascal, F Rodriguez, FR Robinson, H Koyama, HC Carlson, HG Purchase, HM Koo, I Davidson, IS Diallo, IS Diallo, J Hanson, J Li, J Martin, JJ Solomon, JP Stoye, JP Vanderberg, JS McDougall, K Nyakatura, KA Schat, KM Moore, LA Terzian, LE Hayes, LJ Yu, LT Coggeshall, M Barbacid, M Garcia, MJ Peterson, MK Cook, ML Drew, MR Patel, MW Dimmic, MX Motha, N Ratnamohan, N Yuasa, P Singh, PE Miller, PS Paul, PS Sarma, Q Liu, R Crespo, R Gifford, R Isfort, RA Weiss, RB Franklin, RB Franklin, RJ Isfort, RL Witter, RL Witter, RL Witter, RM Corwin, Robert J. Gifford, SB Hitchner, SK Biswas, SL Kosakovsky Pond, T Barbosa, T Tadese, TJ Kim, TM Grimes, VN Kewalramani, W Trager, WG Conway, WH Cheng, Y Wang, Z Cheng, Z Cui, Z Yang, É Brumpt   +95 more
core   +3 more sources

Poxviruses

, 2010
Poxviruses are large, complex DNA viruses that have played several seminal roles in medicine and biological science. Cowpox virus was introduced by Jenner as the first human vaccine in 1796; widespread vaccination with vaccinia virus led to the global eradication of smallpox in 1977, the only human disease to have been eradicated....
Jessica Clark, Dayna Diven
  +4 more sources

Cidofovir Activity against Poxvirus Infections

Viruses, 2010
Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, HPMPC] is an acyclic nucleoside analog approved since 1996 for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
Robert Snoeck, Graciela Andrei
doaj   +1 more source

Retrospective study of poxviruses diagnosed in cattle from Goiás State, Brazil (2010-2018)

Pesquisa Veterinária Brasileira, 2022
: A retrospective study of poxvirus infections diagnosed in cattle from Goiás state (GO), Brazil, from 2010 to 2018, was performed. All cases have been investigated by the GO Official Veterinary Service (Agrodefesa), from which technical forms and ...
Lorena F. Silva, Antônio A. Leal, Paulo H.J. Cunha, Juliana F. Cargnelutti, Eduardo F. Flores, Thiago B. Almeida, Fabiano J.F. Sant’Ana   +6 more
doaj   +1 more source