Results 31 to 40 of about 14,001 (196)
Enhancing the Immunogenicity of Vaccinia Virus
Viruses, 2022 The conventional live smallpox vaccine based on the vaccinia virus (VACV) cannot be widely used today because it is highly reactogenic. Therefore, there is a demand for designing VACV variants possessing enhanced immunogenicity, making it possible to ...
Sergei N. Shchelkunov +11 more
doaj +1 more source
Identification of multiple independent horizontal gene transfers into poxviruses using a comparative genomics approach [PDF]
, 2008 Background Poxviruses are important pathogens of humans, livestock and wild animals. These large dsDNA viruses have a set of core orthologs whose gene order is extremely well conserved throughout poxvirus genera.
Kirsten A Bratke, Aoife McLysaght
core +1 more source
Viruses, 2014 Poxviruses are important pathogens of man and numerous domestic and wild animal species. Cross species (including zoonotic) poxvirus infections can have drastic consequences for the recipient host.
Kate S. Baker, Pablo R. Murcia
doaj +1 more source
Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors [PDF]
, 2010 Histone deacetylase inhibitors (HDI) dampen cellular innate immune response by decreasing interferon production and have been shown to increase the growth of vesicular stomatitis virus and HSV.
Atkins, H +15 more
core +1 more source
Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +1 more source
Journal of Medical Science, 2022 Human monkeypox represents a relatively underexplored infection that has received increased attention since the reported outbreak in May 2022. Due to its clinical similarities with human smallpox, this virus represents a potentially tremendous health ...
Dženan Kovačić, Adna Salihović
doaj +1 more source
Molecular Mechanisms of Poxvirus Evolution
mBio, 2023 Poxviruses are often thought to evolve relatively slowly because they are double-stranded DNA pathogens with proofreading polymerases. However, poxviruses have highly adaptable genomes and can undergo relatively rapid genotypic and phenotypic change, as ...
Greg Brennan +8 more
doaj +1 more source
Frontiers in Microbiology, 2023 The monkeypox virus (MPXV) has become a major threat due to the increasing global caseload and the ongoing multi-country outbreak in non-endemic territories.
Pallavi Gulati +3 more
doaj +1 more source
Pathogens, 2020 The synthesis of host cell proteins is adversely inhibited in many virus infections, whereas viral proteins are efficiently synthesized. This phenomenon leads to the accumulation of viral proteins concurrently with a profound decline in global host ...
Pragyesh Dhungel +3 more
doaj +1 more source
Tattoo Skin Disease in Cetacea: A Review, with New Cases for the Northeast Pacific
Animals, 2022 Tattoo skin disease (TSD) is a poxviral dermatopathy diagnosed in cetaceans. We review the literature on TSD aetiology, clinical characteristics, pathology and epidemiology and evaluate immune responses against the virus.
Marie-Françoise Van Bressem +2 more
doaj +1 more source