Results 1 to 10 of about 362 (144)

Pro-Tumorigenic Phosphorylation of p120 Catenin in Renal and Breast Cancer. [PDF]

PLoS ONE, 2015
Altered protein expression and phosphorylation are common events during malignant transformation. These perturbations have been widely explored in the context of E-cadherin cell-cell adhesion complexes, which are central in the maintenance of the normal ...
Antonis Kourtidis, Masahiro Yanagisawa, Deborah Huveldt, John A Copland, Panos Z Anastasiadis   +4 more
doaj   +3 more sources

The Differential Effects of pp120 (Ceacam 1) on the Mitogenic Action of Insulin and Insulin-Like Growth Factor 1 Are Regulated by the Nonconserved Tyrosine 1316 in the Insulin Receptor [PDF]

Molecular and Cellular Biology, 2000
pp120 (Ceacam 1) undergoes ligand-stimulated phosphorylation by the insulin receptor, but not by the insulin-like growth factor 1 receptor (IGF-1R). This differential phosphorylation is regulated by the C terminus of the beta-subunit of the insulin receptor, the least conserved domain of the two receptors.
Matthew N Poy, Sonia M Najjar
exaly   +5 more sources

Neural mapping of prepulse-induced startle reflex modulation as indices of sensory information processing in healthy and clinical populations: A systematic review. [PDF]

Hum Brain Mapp, 2021
Abstract Startle reflex is modulated when a weaker sensory stimulus (“prepulse”) precedes a startling stimulus (“pulse”). Prepulse Inhibition (PPI) is the attenuation of the startle reflex (prepulse precedes pulse by 30–500 ms), whereas Prepulse Facilitation (PPF) is the enhancement of the startle reflex (prepulse precedes pulse by 500–6000 ms).
Naysmith LF, Kumari V, Williams SCR.
europepmc   +2 more sources

Impaired glucose tolerance is associated with enhanced postprandial pancreatic polypeptide secretion. [PDF]

J Diabetes, 2022
Highlights Compared with normal glucose tolerance subjects, impaired glucose regulation and type 2 diabetes mellitus (T2DM) patients have an enhanced postprandial pancreatic polypeptide (PP) secretion. In patients with T2DM, the secretion of PP is mainly affected by body mass index and blood glucose.
Zhao Y, Zhou Y, Xiao M, Huang Y, Qi M, Kong Z, Chi J, Che K, Lv W, Dong B, Wang Y.   +10 more
europepmc   +2 more sources

Current perspective on biological properties of plasmacytoid dendritic cells and dysfunction in gut. [PDF]

Immun Inflamm Dis, 2023
pDCs are a subset of dendritic cells, and transcription factors play a crucial role in the process. pDCs contribute to intestinal immune responses by generating interferon (IFN) and presenting antigens. pDCs guard the intestinal mucosa and protect against the invasion of microbiota and pathogens in the gut, playing a pivotal role in gut infection and ...
Guo X, He C, Xin S, Gao H, Wang B, Liu X, Zhang S, Gong F, Yu X, Pan L, Sun F, Xu J.   +11 more
europepmc   +2 more sources

Mechanism and function of CEACAM1 splice isoforms. [PDF]

Eur J Clin Invest
Abstract Background Alternative splicing is a fundamental mechanism in the post‐transcriptional regulation of genes. The multifunctional transmembrane glycoprotein receptor carcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) undergoes extensive alternative splicing to allow for tunable functions in cell signalling, adhesion and ...
Dery KJ, Najjar SM, Beauchemin N, Shively JE, Kupiec-Weglinski JW.   +4 more
europepmc   +2 more sources

Phenotypic drift in metastatic progression of breast cancer: A case report with histologically heterogeneous lesions that are clonally related. [PDF]

Clin Case Rep, 2020
Breast cancer metastasis to the stomach is rare; invasive lobular carcinoma has a predilection to spread to the gastrointestinal system and is morphologically similar to primary diffuse gastric carcinoma. This case highlights heterogeneous metastatic progression and that documentation of heterogeneity is important for informing future treatment ...
Kutasovic JR, McCart Reed AE, Sokolova A, Jayanthan J, Da Silva L, Simpson PT, Lakhani SR.   +6 more
europepmc   +2 more sources

Insulin Stimulates pp120 Endocytosis in Cells Co-expressing Insulin Receptors [PDF]

Journal of Biological Chemistry, 1998
pp120, a substrate of the insulin receptor tyrosine kinase, is a plasma membrane glycoprotein that is expressed in the hepatocyte as two spliced isoforms differing by the presence (full-length) or absence (truncated) of most of the intracellular domain including all phosphorylation sites.
Marthe J Howard, Matthew N Poy, Mark H Hankin   +2 more
exaly   +3 more sources

PP120 Fluorescent In Situ Hybridization (FISH) Vs Conventional Cytogenetic (CC) For Detecting High-Risk Genetic Mutations In Multiple Myeloma [PDF]

Int J Technol Assess Health Care, 2022
IntroductionThe Revised International Staging System (R-ISS) International Myeloma Working Group (IMWG) recommends a minimal panel to detect high-risk cytogenetics (del17p, t[4;14], t[14;16]) for patients with multiple myeloma (MM). In the Brazilian Public Health System, the use of FISH is currently authorized for rare diseases only, not including MM ...
Denis Satoshi Komoda, Marilia Berlofa Visacri, Carlos Roberto Correa, Daniela Santos, Flavia Maia, Mayra Ribeiro   +5 more
europepmc   +2 more sources

Effect of pp120 on Receptor-mediated Insulin Endocytosis Is Regulated by the Juxtamembrane Domain of the Insulin Receptor [PDF]

Journal of Biological Chemistry, 1998
pp120, a substrate of the insulin receptor tyrosine kinase, does not undergo ligand-stimulated phosphorylation by the insulin-like growth factor-1 (IGF-1) receptor. However, replacement of the C-terminal domain of the IGF-1 receptor beta-subunit with the corresponding segment of the insulin receptor restored pp120 phosphorylation by the chimeric ...
Sonia M Najjar, Matthew N Poy
exaly   +3 more sources