Results 131 to 140 of about 1,864 (157)
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PP120 Health Technology Assessment Framework To Capture The Full Value Of Value Added Medicines
International Journal of Technology Assessment in Health Care, 2017INTRODUCTION:Value added medicines (VAM) are medicines based on known molecules that address healthcare needs and deliver relevant improvements for patients, healthcare professionals and/or payers through drug repositioning, drug reformulation or drug combination (1-3).
Mondher Toumi +2 more
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Molecular Cloning of pp120/ ECTO-ATPase, An Endogenous Substrate of the Insulin Receptor Kinase
1994In recent years, a great deal of attention has been devoted to dissecting intracellular pathways of insulin action following activation of the insulin receptor kinase (1). Several laboratories have reported the identification of protein substrates of the insulin receptor tyrosine kinase (2).
S M, Najjar +3 more
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The Journal of Immunology, 1998
AbstractAccumulating evidence indicates that the Src homology 2-containing tyrosine phosphatase 2 (SHP-2) plays an important role in signal transduction through receptor tyrosine kinase and cytokine receptors. In most models, SHP-2 appears to be a positive mediator of signaling.
Kazuhiro Nakamura, John C. Cambier
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AbstractAccumulating evidence indicates that the Src homology 2-containing tyrosine phosphatase 2 (SHP-2) plays an important role in signal transduction through receptor tyrosine kinase and cytokine receptors. In most models, SHP-2 appears to be a positive mediator of signaling.
Kazuhiro Nakamura, John C. Cambier
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Clinical Nutrition, 2013
Rationale: Serum albumin levels are one of indicators for evaluating nutritional status and correlate negatively with C-reactive protein levels, a risk marker of inflammatory process of vascular atherogenesis, affecting circadian blood pressure (BP) rhythm.
G. Yasuda +4 more
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Rationale: Serum albumin levels are one of indicators for evaluating nutritional status and correlate negatively with C-reactive protein levels, a risk marker of inflammatory process of vascular atherogenesis, affecting circadian blood pressure (BP) rhythm.
G. Yasuda +4 more
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1997
ppl20/C-CAM, a liver plasma membrane glycoprotein, is a substrate of the insulin receptor tyrosine kinase in cell-free and intact cell systems.1, 2, 3 The cDNA encoding the rat protein was originally cloned by Lin and Guidotti4 as a Ca2+/Mg2+ ecto-ATPase. Analysis of the deduced amino acid sequence revealed that the protein is of 519 amino acids (a.a.)
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ppl20/C-CAM, a liver plasma membrane glycoprotein, is a substrate of the insulin receptor tyrosine kinase in cell-free and intact cell systems.1, 2, 3 The cDNA encoding the rat protein was originally cloned by Lin and Guidotti4 as a Ca2+/Mg2+ ecto-ATPase. Analysis of the deduced amino acid sequence revealed that the protein is of 519 amino acids (a.a.)
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Is the Rat Liver Ecto-ATPase Identical to C-CAM/PP120, a Cell Adhesion Molecule?
1997The publication of a report on the molecular cloning of the rat liver ecto-ATPase1 in 1989 was considered a major break-through in ecto-ATPase research, especially since no other ecto-ATPase had been purified at that time. The extensive homology of the cDNA sequence of the rat liver ecto-ATPase with human biliary glycoprotein I (BGPI) also gave hope ...
Aileen F. Knowles +2 more
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Biochemical and Biophysical Research Communications, 1990
pp120/HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a ...
R N, Margolis +3 more
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pp120/HA4, a membrane protein found in hepatocyte plasma membranes and a substrate for the insulin receptor tyrosine kinase, was purified to homogeneity, subjected to partial proteolysis, and peptides were sequenced by Edman degradation. Six amino acid sequences were obtained, and they matched the deduced amino acid sequences of six regions of a ...
R N, Margolis +3 more
openaire +2 more sources
Journal of immunology (Baltimore, Md. : 1950), 1998
Accumulating evidence indicates that the Src homology 2-containing tyrosine phosphatase 2 (SHP-2) plays an important role in signal transduction through receptor tyrosine kinase and cytokine receptors. In most models, SHP-2 appears to be a positive mediator of signaling.
K, Nakamura, J C, Cambier
openaire +1 more source
Accumulating evidence indicates that the Src homology 2-containing tyrosine phosphatase 2 (SHP-2) plays an important role in signal transduction through receptor tyrosine kinase and cytokine receptors. In most models, SHP-2 appears to be a positive mediator of signaling.
K, Nakamura, J C, Cambier
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PP120-SUN OVERWEIGHT IS ASSOCIATED WITH UNBALANCED OF ADIPOCITOKINES IN ADOLESCENTS
Clinical Nutrition, 2013A.P.Q. Mello +2 more
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