Results 1 to 10 of about 2,303 (111)

Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development. [PDF]

PLoS Pathogens, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Wei Liu, Xinghong Dai, Jonathan Jih, Karen Chan, Phong Trang, Xuekui Yu, Rilwan Balogun, Ye Mei, Fenyong Liu, Z Hong Zhou   +9 more
doaj   +3 more sources

Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection [PDF]

Viruses, 2021
Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and ...
Dipanwita Mitra, Mohammad H. Hasan, John T. Bates, Gene L. Bidwell, Ritesh Tandon   +4 more
doaj   +2 more sources

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly [PDF]

mBio, 2022
Morphogenesis of herpesvirus particles is highly conserved; however, the capsid assembly and genome packaging of human cytomegalovirus (HCMV) exhibit unique features.
Eva Maria Borst, Sarah Harmening, Saskia Sanders, Enrico Caragliano, Karen Wagner, Tihana Lenac Roviš, Stipan Jonjić, Jens Bernhard Bosse, Martin Messerle   +8 more
doaj   +2 more sources

A promising endeavor against human cytomegalovirus: Predominant epitopes-based recombinant subunit vaccine RHEcIE1/pp65/pp150 [PDF]

Virulence
Human cytomegalovirus (HCMV) is widespread in the population, typically remaining latent. However, it can cause severe morbidity and mortality in transplant patients and immunodeficient individuals.
Zonghui Li, Shasha Jiang, Wenxuan Liu, Xiaoli Yang, Fengjun Liu, Xu Li, Jun Li, Meng Yu, Zhun Wei, Bin Wang, Dongmeng Qian   +10 more
doaj   +2 more sources

Whole CMV proteome pattern recognition analysis after HSCT identifies unique epitope targets associated with the CMV status. [PDF]

PLoS ONE, 2014
Cytomegalovirus (CMV) infection represents a vital complication after Hematopoietic Stem Cell Transplantation (HSCT). We screened the entire CMV proteome to visualize the humoral target epitope-focus profile in serum after HSCT.
Lena Pérez-Bercoff, Davide Valentini, Simani Gaseitsiwe, Shahnaz Mahdavifar, Mike Schutkowski, Thomas Poiret, Åsa Pérez-Bercoff, Per Ljungman, Markus J Maeurer   +8 more
doaj   +4 more sources

Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150 [PDF]

Nature Communications, 2021
Here, cryo-EM reconstructions of human cytomegalovirus (HCMV) virions reveal host tRNAs associated with the virion’s capsid-bound tegument protein, pp150. tRNA recruitment is mediated by the interactions specific for HCMV only, suggesting the explanation
Yun-Tao Liu, David Strugatsky, Wei Liu, Z. Hong Zhou   +3 more
doaj   +2 more sources

Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of life [PDF]

Scientific Reports
Cytomegalovirus (CMV) causes infections that last a lifetime and are primarily contracted in childhood. Congenital transmitted CMV is associated with severe neurological sequelae and can cause life-threatening disease in immunocompromised individuals ...
Maureen W. Mburu, Mercy S. Safari, Timothy O. Makori, Elijah T. Gicheru, Omar K. Nyawa, Timothy Chege Kuria, Deirdre J. Foley, Charles J. Sande   +7 more
doaj   +2 more sources

An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]

Scientific Reports
The tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton, Dipanwita Mitra, Adesanya A. Akinleye, John A. Howell, Christian S. Yu, Gene L. Bidwell, Ritesh Tandon   +6 more
doaj   +2 more sources

Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona [PDF]

Frontiers in Public Health
BackgroundFrom a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and ...
Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, José Pumarega, José Pumarega, José Pumarega, Ruth Aguilar, Ruth Aguilar, David Prieto-Merino, Laura Campi, Laura Campi, Cristina Rius, Cristina Rius, Cristina Rius, Judit Villar-García, Marta Vidal, Marta Vidal, Marta Vidal, Alfons Jimenez, Alfons Jimenez, Alfons Jimenez, Antonio Peña, Miguel-Ángel Muñoz, Miguel-Ángel Muñoz, Leonardo Trasande, Leonardo Trasande, Leonardo Trasande, Francisco Bolúmar, Francisco Bolúmar, Gemma Moncunill, Gemma Moncunill, Gemma Moncunill, Magda Gasull, Magda Gasull, Magda Gasull, Carlota Dobaño, Carlota Dobaño, Carlota Dobaño   +40 more
doaj   +2 more sources

Optimized multi-epitope neoantigen human cytomegalovirus vaccine based on adenovirus vectors elicits potent antiviral immunity [PDF]

Frontiers in Immunology
IntroductionHuman cytomegalovirus (HCMV) induces severe morbidity and mortality in neonates, organ transplant recipients, and immunocompromised individuals. Currently, there is no licensed vaccine for HCMV.
Shasha Jiang, Shasha Jiang, Xianjuan Zhang, Heping Zhao, Fengjun Liu, Fengjun Liu, Zonghui Li, Zonghui Li, Xiaoli Yang, Xiaoli Yang, Wenxuan Liu, Jing Lv, Yi Zhang, Yiran Zhang, Yan Yu, Bin Wang, Yunyang Wang   +16 more
doaj   +2 more sources