Results 11 to 20 of about 907 (167)

Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28) [PDF]

Virology Journal, 2012
Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub-family of Herpesviridae family, is a widespread pathogen that infects a majority of the world's population by early adulthood.
Tomtishen III John
doaj   +5 more sources

Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus. [PDF]

PLoS Pathogens, 2017
Generally, the antagonism between host restriction factors and viral countermeasures decides on cellular permissiveness or resistance to virus infection.
Henry Weisbach, Christoph Schablowsky, Barbara Vetter, Iris Gruska, Christian Hagemeier, Lüder Wiebusch   +5 more
doaj   +2 more sources

Effect of Cytomegalovirus Recombinant Phosphoprotein 150 (pp150) on Function and Maturation of Murine Dendritic Cells: an In-Vitro Study [PDF]

Iranian Journal of Immunology, 2020
Background: Tegument protein pp150 of cytomegaloviruses (CMVs) plays a vital role in all stages of viral life cycle, representing the most important tegument protein candidate for HCMV treatment.
Yousef Nikmanesh, Shohreh Shahmahmoodi, Ramin Yaghobi, Sayed Mahdi Marashi, Mahmood Mahmoudi, Mahdokht Hossein Aghdaie, Maryam Khosravi, Mohammad Hossein Karimi   +7 more
doaj   +3 more sources

Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona [PDF]

Frontiers in Public Health
BackgroundFrom a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and ...
Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, Miquel Porta, José Pumarega, José Pumarega, José Pumarega, Ruth Aguilar, Ruth Aguilar, David Prieto-Merino, Laura Campi, Laura Campi, Cristina Rius, Cristina Rius, Cristina Rius, Judit Villar-García, Marta Vidal, Marta Vidal, Marta Vidal, Alfons Jimenez, Alfons Jimenez, Alfons Jimenez, Antonio Peña, Miguel-Ángel Muñoz, Miguel-Ángel Muñoz, Leonardo Trasande, Leonardo Trasande, Leonardo Trasande, Francisco Bolúmar, Francisco Bolúmar, Gemma Moncunill, Gemma Moncunill, Gemma Moncunill, Magda Gasull, Magda Gasull, Magda Gasull, Carlota Dobaño, Carlota Dobaño, Carlota Dobaño   +40 more
doaj   +2 more sources

Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies [PDF]

Virology Journal, 2009
Background Human cytomegalovirus infection is associated with a variety of pathological conditions including retinitis, pneumonia, hepatitis and encephalitis that may be transmitted congenitally, horizontally and parenterally and occurs both as a primary
Alter Harvey J, Drew W Lawrence, Exner Maurice, Ching Kathryn H, Issa Alexandra T, Burbelo Peter D, Iadarola Michael J   +6 more
doaj   +2 more sources

Identification of a human cytomegalovirus mutant in the pp150 matrix phosphoprotein gene with a growth-defective phenotype

Journal of General Virology, 1993
Following amplification by PCR of a portion of the matrix phosphoprotein pp150 gene, electrophoretic analysis revealed the simultaneous presence of two viral variants of human cytomegalovirus in the blood of a heart transplant recipient. Repeated denaturation-annealing cycles during the amplification reaction led to the formation of heteroduplex ...
Zipeto D., Baldanti F., Percivalle E., Gerna G., Milanesi G.   +4 more
openaire   +4 more sources

Human cytomegalovirus tegument protein pp150 acts as a cyclin A2–CDK-dependent sensor of the host cell cycle and differentiation state [PDF]

Proceedings of the National Academy of Sciences, 2013
Significance Depending on the host cell type and differentiation status, herpesviruses establish different modes of infection to either maintain or replicate their genomes. How viruses discriminate between individual host cell environments upon infection is poorly understood.
Bogdanow, Boris, Weisbach, Henry, von Einem, Jens, Straschewski, Sarah, Voigt, Sebastian, Winkler, Michael, Hagemeier, Christian, Wiebusch, Lüder   +7 more
openaire   +4 more sources

Optimized multi-epitope neoantigen human cytomegalovirus vaccine based on adenovirus vectors elicits potent antiviral immunity [PDF]

Frontiers in Immunology
IntroductionHuman cytomegalovirus (HCMV) induces severe morbidity and mortality in neonates, organ transplant recipients, and immunocompromised individuals. Currently, there is no licensed vaccine for HCMV.
Shasha Jiang, Shasha Jiang, Xianjuan Zhang, Heping Zhao, Fengjun Liu, Fengjun Liu, Zonghui Li, Zonghui Li, Xiaoli Yang, Xiaoli Yang, Wenxuan Liu, Jing Lv, Yi Zhang, Yiran Zhang, Yan Yu, Bin Wang, Yunyang Wang   +16 more
doaj   +2 more sources

Predictive value of gB2 antibodies for maternal-fetal transmission after primary cytomegalovirus infection treated with valacyclovir. [PDF]

Ultrasound Obstet Gynecol
ABSTRACT Objective To estimate the residual risk of maternal–fetal transmission after primary cytomegalovirus (CMV) infection in the periconceptional period or the first trimester in women treated with valacyclovir, and to assess whether the presence of glycoprotein B2 (gB2)‐specific immunoglobulin (Ig)‐G antibodies on immunoblot analysis refines fetal
Kagan KO, Bissinger AL, Roth O, Sonek J, Hoopmann M, Ville Y, Enders M.   +6 more
europepmc   +2 more sources

Structure-Guided Mutagenesis Targeting Interactions Between pp150 Tegument Protein and Small Capsid Protein Identify Five Lethal and Two Live-Attenuated HCMV Mutants [PDF]

Virology
Qiyi Tang, Hong Zhou, Alexander Stevens
exaly   +2 more sources