Results 1 to 10 of about 907 (167)

Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection [PDF]

Viruses, 2021
Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and ...
John T. Bates, Ritesh Tandon, Gene L Bidwell   +2 more
exaly   +10 more sources

Structure of Human Cytomegalovirus Virion Reveals Host tRNA Binding to Capsid-Associated Tegument Protein pp150 [PDF]

Nature Communications, 2021
Here, cryo-EM reconstructions of human cytomegalovirus (HCMV) virions reveal host tRNAs associated with the virion’s capsid-bound tegument protein, pp150. tRNA recruitment is mediated by the interactions specific for HCMV only, suggesting the explanation
Wei Liu, Hong Zhou, Yun-Tao Liu
exaly   +10 more sources

A promising endeavor against human cytomegalovirus: Predominant epitopes-based recombinant subunit vaccine RHEcIE1/pp65/pp150 [PDF]

Virulence
Human cytomegalovirus (HCMV) is widespread in the population, typically remaining latent. However, it can cause severe morbidity and mortality in transplant patients and immunodeficient individuals.
Zonghui Li, Shasha Jiang, Wenxuan Liu, Xiaoli Yang, Fengjun Liu, Xu Li, Jun Li, Meng Yu, Zhun Wei, Bin Wang, Dongmeng Qian   +10 more
doaj   +5 more sources

The Smallest Capsid Protein Mediates Binding of the Essential Tegument Protein pp150 to Stabilize DNA-Containing Capsids in Human Cytomegalovirus [PDF]

PLoS Pathogens, 2013
Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised individuals. Among all human herpesviruses, HCMV contains a much larger dsDNA genome within a similarly-
Fenyong Liu, Xinghong Dai, Xuekui Yu
exaly   +9 more sources

Atomic Structures and Deletion Mutant Reveal Different Capsid-Binding Patterns and Functional Significance of Tegument Protein pp150 in Murine and Human Cytomegaloviruses With Implications for Therapeutic Development [PDF]

PLoS Pathogens, 2019
Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Jonathan Jih, Fenyong Liu, Wei Liu
exaly   +3 more sources

A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly [PDF]

mBio, 2022
Morphogenesis of herpesvirus particles is highly conserved; however, the capsid assembly and genome packaging of human cytomegalovirus (HCMV) exhibit unique features.
Eva Maria Borst, Sarah Harmening, Saskia Sanders, Enrico Caragliano, Karen Wagner, Tihana Lenac Roviš, Stipan Jonjić, Jens Bernhard Bosse, Martin Messerle   +8 more
doaj   +3 more sources

Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of life [PDF]

Scientific Reports
Cytomegalovirus (CMV) causes infections that last a lifetime and are primarily contracted in childhood. Congenital transmitted CMV is associated with severe neurological sequelae and can cause life-threatening disease in immunocompromised individuals ...
Maureen W. Mburu, Mercy S. Safari, Timothy O. Makori, Elijah T. Gicheru, Omar K. Nyawa, Timothy Chege Kuria, Deirdre J. Foley, Charles J. Sande   +7 more
doaj   +3 more sources

Development and performance evaluation of a recombinant antigen - based ELISA and immunochromatography test for HCMV IgG detection [PDF]

BMC Infectious Diseases
Background Human cytomegalovirus (HCMV) is a common pathogen that poses significant health risks, particularly to immunocompromised individuals. This study aims to improve diagnostic accuracy by developing a novel enzyme-linked immunosorbent assay (ELISA)
Mengjiao Lin, Ni Yao, Miaomiao Li, Yushan Xu, Dawei Cui, Jue Xie   +5 more
doaj   +2 more sources

The causal relationship between antibody-mediated immune responses to infections and Graves’ disease: a bi-directional Mendelian randomization analysis [PDF]

Experimental Biology and Medicine
The pathogenesis of Graves’ disease (GD) has not been fully elucidated, and antibody-mediated immune responses following microbial infection may be involved in its development.
Xinwei Zhang, Xinwei Zhang, Wenyu Xu, Zhou Liu, Jinan Zhang, Jinan Zhang, Xiaorong Yang   +6 more
doaj   +2 more sources

An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]

Scientific Reports
The tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton, Dipanwita Mitra, Adesanya A. Akinleye, John A. Howell, Christian S. Yu, Gene L. Bidwell, Ritesh Tandon   +6 more
doaj   +2 more sources