Tegument Protein pp150 Sequence-Specific Peptide Blocks Cytomegalovirus Infection [PDF]
Viruses, 2021 Human cytomegalovirus (HCMV) tegument protein pp150 is essential for the completion of the final steps in virion maturation. Earlier studies indicated that three pp150nt (N-terminal one-third of pp150) conformers cluster on each triplex (Tri1, Tri2A and ...
Dipanwita Mitra +2 more
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Structure of human cytomegalovirus virion reveals host tRNA binding to capsid-associated tegument protein pp150 [PDF]
Nature Communications, 2021 Here, cryo-EM reconstructions of human cytomegalovirus (HCMV) virions reveal host tRNAs associated with the virion’s capsid-bound tegument protein, pp150. tRNA recruitment is mediated by the interactions specific for HCMV only, suggesting the explanation
Yun-Tao Liu, Ｗei Liu, Z Hong Zhou
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A promising endeavor against human cytomegalovirus: Predominant epitopes-based recombinant subunit vaccine RHEcIE1/pp65/pp150 [PDF]
VirulenceHuman cytomegalovirus (HCMV) is widespread in the population, typically remaining latent. However, it can cause severe morbidity and mortality in transplant patients and immunodeficient individuals.
Zonghui Li +10 more
doaj +5 more sources
The Smallest Capsid Protein Mediates Binding of the Essential Tegument Protein pp150 to Stabilize DNA-Containing Capsids in Human Cytomegalovirus [PDF]
PLoS Pathogens, 2013 Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that causes birth defects in newborns and life-threatening complications in immunocompromised individuals. Among all human herpesviruses, HCMV contains a much larger dsDNA genome within a similarly-
Xinghong Dai +2 more
exaly +9 more sources
Human cytomegalovirus tegument proteins (pp65, pp71, pp150, pp28) [PDF]
Virology Journal, 2012 Human cytomegalovirus (HCMV), a member of the Betaherpesvirinae sub-family of Herpesviridae family, is a widespread pathogen that infects a majority of the world's population by early adulthood.
Tomtishen III John
doaj +5 more sources
Atomic structures and deletion mutant reveal different capsid-binding patterns and functional significance of tegument protein pp150 in murine and human cytomegaloviruses with implications for therapeutic development [PDF]
PLoS Pathogens, 2019 Cytomegalovirus (CMV) infection causes birth defects and life-threatening complications in immunosuppressed patients. Lack of vaccine and need for more effective drugs have driven widespread ongoing therapeutic development efforts against human CMV (HCMV)
Ｗei Liu, Xinghong Dai, Jonathan Jih
exaly +3 more sources
A Unique Role of the Human Cytomegalovirus Small Capsid Protein in Capsid Assembly [PDF]
mBio, 2022 Morphogenesis of herpesvirus particles is highly conserved; however, the capsid assembly and genome packaging of human cytomegalovirus (HCMV) exhibit unique features.
Eva Maria Borst +8 more
doaj +3 more sources
Long-term dynamics of cytomegalovirus-specific antibodies in a longitudinal cohort of children followed up for the first decade of life [PDF]
Scientific ReportsCytomegalovirus (CMV) causes infections that last a lifetime and are primarily contracted in childhood. Congenital transmitted CMV is associated with severe neurological sequelae and can cause life-threatening disease in immunocompromised individuals ...
Maureen W. Mburu +7 more
doaj +3 more sources
Synthetic lethal mutations in the cyclin A interface of human cytomegalovirus. [PDF]
PLoS Pathogens, 2017 Generally, the antagonism between host restriction factors and viral countermeasures decides on cellular permissiveness or resistance to virus infection.
Henry Weisbach +5 more
doaj +2 more sources
An Elastin-like Polypeptide-fusion peptide targeting capsid-tegument interface as an antiviral against cytomegalovirus infection [PDF]
Scientific ReportsThe tegument protein pp150 of Human Cytomegalovirus (HCMV) is known to be essential for the final stages of virus maturation and mediates its functions by interacting with capsid proteins.
Komal Beeton +6 more
doaj +2 more sources