Results 181 to 190 of about 52,072 (220)

Correction: Chronic administration of Metformin exerts cytostatic and cytotoxic effects via the PP2A-GSK3β-MCL-1 pathway by inhibiting the tmCLIC1 membrane protein in glioblastoma-initiating cells. [PDF]

J Exp Clin Cancer Res
Cianci F, Verduci I, Cazzoli R, Cannavale G, Rey G, Veronesi M, Balboni B, Ranucci M, Palloni LMG, Ballabio F, Barsotti N, Ailuno G, Balboni A, Baldassari S, Caviglioli G, Tacconi C, Camilloni C, Girotto S, Fantin A, Barbieri F, Cavalli A, Pasqualetti M, Florio T, Minucci S, Mazzanti M.   +24 more
europepmc   +1 more source

APOE4 Exacerbates Cerebral Tau Pathology Through Cholesterol-Induced Degradation of Phosphatase in Atherosclerosis. [PDF]

CNS Neurosci Ther
Ding J, Sun B, Gao Y, Gu C, Zhang J, Wang L, Zheng J, Xia B, Qi X.   +8 more
europepmc   +1 more source

IX Finnish Symposium on Plant Science, May 17-19, 2010, Joensuu, Finland abstracts [PDF]

Huttunen, Markku A. (ed.), Oksanen, Elina. (ed.)   +1 more
core  

PPP2R2A insufficiency enhances PD-L1 immune checkpoint blockade efficacy in lung cancer through cGAS-STING activation. [PDF]

J Clin Invest
Qiu Z, Song NJ, Li A, Singh D, Prasad CB, Yan C, Carbone DP, Wang QE, Zhang X, Li Z, Zhang J.   +10 more
europepmc   +1 more source

The fungal STRIPAK complex: Cellular conductor orchestrating growth and pathogenicity. [PDF]

PLoS Pathog
Peterson PP, Heitman J.
europepmc   +1 more source

Regulation of cell proliferation by a novel feedback system on Cdk function

Ryan JC, Leray B, Jain A, Coehlo N, Domingo-Sananes MR, Aspert T, Charvin G, Krockenberger MS, Chica Blaguera N, Lopez Aviles S, Takacs L, Uhlmann F, Yang L, Yue J, Liti G, Cochard V, Chevreux G, Sugiyama H, Goto Y, Aoki K, Wu PJ, Mackereth C, Tyson J, Novák B, Coudreuse D.   +24 more
europepmc   +1 more source

Pathogen effector forms a hexameric phosphatase holoenzyme with host core enzyme to promote disease

Wang J, Li H, Sun W, Wang J, Fang X, Yang X, Liu C, Sheng G, Ma W, Wang Y.   +9 more
europepmc   +1 more source

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PP2A: the expected tumor suppressor

Current Opinion in Genetics and Development, 2005
PP2A is one of the few serine/threonine-specific phosphatases in the cell, and its complex structure and regulation guarantees its many different functions. Some viruses have chosen to target this enzyme system in order to manage the host cell machinery for their own profit and to program cells into a malignant state.
Veerle Janssens
exaly   +3 more sources

PP2A and Alzheimer Disease

Current Alzheimer Research, 2012
Phosphorylation and, therefore, binding capacity of microtubule-associated protein tau is regulated by specific kinases and phosphatases. Activation of tau kinases plays a crucial role in tau- hyper-phosphorylation in Alzheimer disease (AD) and related tauopathies.
L, Torrent, I, Ferrer
openaire   +2 more sources

PP2A to Alzheimer’s rescue

Science Signaling, 2016
Transgenic mice with altered methylation of PP2A reveal a new strategy for treating Alzheimer’s disease.
Sudhakaran Prabakaran, Nancy R. Gough
openaire   +1 more source