Results 271 to 280 of about 121,549 (307)

The Nuclear Receptor Nurr1 Modulates the Expression and Activity of PPARγ in Human Pro-Inflammatory Macrophages. [PDF]

Scand J Immunol
Santana-Cisneros E, Solís-Barbosa MA, Segovia-Gamboa NC, Meraz-Ríos MA, González-Domínguez E, Hernández-Rivas R, Marrero-Rodríguez D, Sanchez-Torres C.   +7 more
europepmc   +1 more source

Ihmisen apolipoproteiinien ekspressio ja niiden säätely PPAR:llä [PDF]

Uski, Oskari
core  

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell, Joshua A. Kulas, William E. Carter, June Javens‐Wolfe, Raven Dance Hinkel, Mustapha Moussaif, Jacob S. Smiley, Olivia Lazaro, Sylvia Robertson, Alan D. Palkowitz, Bruce T. Lamb, Timothy I. Richardson, Jeffrey L. Dage, Shaoyou Chu, Travis Johnson, Louis F. Stancato, Abdul Qadir Syed   +16 more
wiley   +1 more source

Dendrobine alleviates CCl₄-induced acute liver injury by inhibiting necroptosis through activation of the Nrf2/PPARγ/SOD2 signaling pathways. [PDF]

Chin Med
Yang Y, Fu X, Tan L, Xian S, Fan N, Gan Q, Nan N, Hu L, Shi J, Wu Q, Zhou S.   +10 more
europepmc   +1 more source

An Anoikis Resistance Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Blockades in Gastric Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Gastric cancer (GC) has high global incidence and mortality, with most cases diagnosed at advanced stages. Immunotherapy, particularly immune checkpoint blockers (ICBs), has shown promise, but not all patients benefit. This study applied consensus clustering based on anoikis‐related genes (ANRGs) to classify GC into two subclusters.
Xing Cai, Jinru Yang, Fangyuan Zhang, Fuwang Xu, Yuan Fang, Zongbi Yi   +5 more
wiley   +1 more source

CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis. [PDF]

Cell Mol Biol Lett
Li Y, Li H, Chen X, Li X, Su J, Yang S, Xiao W, Deng Z.   +7 more
europepmc   +1 more source

ATGL From iWAT and BAT Is Crucial for Cardiac Remodeling and Metabolism After Myocardial Ischemia/Reperfusion

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
Cardiac I/R activates adipose tissue. iatATGL‐KO increases adipocyte size and reduces lipogenesis in WAT, induces whitening and inflammation in BAT, and reduces circulating NEFA and adiponectin levels. As a consequence, cardiac function is reduced, scar formation enhanced, and remote myocardium shows elevated mechanical stress and oxygen consumption ...
Heba Zabri, Alisa Ucar, Luzhou Wang, Simone Gorressen, Richard Kretschmer, Daniel Gorski, Tobias Lautwein, Mirela Balan, Stefan Lehr, Andre Heinen, Axel Gödecke, Jens W. Fischer, Katharina Bottermann   +12 more
wiley   +1 more source

Fecal microbiota transplantation ameliorates radiation-induced lung injury by reshaping gut metabolic homeostasis to activate FAM134B-mediated ER-phagy. [PDF]

PLoS Pathog
Pu X, Liu B, Dong L, Yuan M, Jin S, Jiang X.   +5 more
europepmc   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic‐cell clearance to therapeutic targeting

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Qianlu Yang, Jie Yan, Qianxi Yang
wiley   +1 more source