Results 251 to 260 of about 74,506 (264)

Network Pharmacology Analysis of Glycyrrhetinic Acid in Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Metabolites
Jaramillo-Morales OA, Cruz-Trujillo R, De la Torre-Sosa CN, Corzo-Gómez JC, Domínguez-Cruz DC, Cruz-Cadena RE, Vega-Cabrera NV, Espinosa-Juárez JV.   +7 more
europepmc   +1 more source

Epoxy Clerodane Diterpene Attenuates the Differentiated Adipocyte Hypertrophy and Enhances Mitochondrial Metabolism

ChemistryOpen, Volume 15, Issue 7, July 2026.
Epoxy Clerodane Diterpene (ECD) significantly reduces adipocyte hypertrophy and lipid accumulation in human mesenchymal stem cell (hMSC)‐derived adipocytes. ECD improves mitochondrial membrane potential (ΔΨm), increases thermogenic regulators (UCP‐1, PPARγC1α), decreases adipogenic markers (C/EBPα, PPARγ), and reduces inflammatory mediators (TNF‐α, NF ...
Sahar Abdulaziz AlSedairy, Pandurangan Subash‐Babu, Maha H. Alhussain, Manal Abdulaziz Binobead, Ali A. Alshatwi   +4 more
wiley   +1 more source

MEX3A Modulates PPARγ Pathway Activity and Colorectal Cancer Growth. [PDF]

Cell Mol Gastroenterol Hepatol
Silva AR, Coelho A, Machado V, Russel M, Mexieiro D, Amaral AL, Cavadas B, Mendes N, Carvalho-Maia C, Gigliano D, Jerónimo C, Almeida R, Pereira B.   +12 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, Volume 269, Issue 3, Page 268-283, July 2026.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Macrophage FTO deficiency accelerates atherosclerosis via PACS2-mediated activation of the PPARγ lipid signaling pathway. [PDF]

J Transl Med
Ouyang J, Zhan Z, Long H, Chen S, Xiang H, Tang B, Liu Q, Qin S, Tao Y, Chen AF, Lu H.   +10 more
europepmc   +1 more source

Rhein attenuates severe acute pancreatitis-associated intestinal injury through PPARγ regulating macrophage activation. [PDF]

Chin Med J (Engl)
Lu H, Shen H, Cui J, Yang J.
europepmc   +1 more source

A simple and robust reporter-based framework for deep functional characterization of PPARγ mutants.

Endocrinology
Baak R, Westland D, de Lange E, Houtman R, Kalkhoven E.   +4 more
europepmc   +1 more source

Activation of PPARγ Attenuates Age-Related Lacrimal Gland Dysfunction by Alleviating Endoplasmic Reticulum Stress-Mediated Ferroptosis. [PDF]

Invest Ophthalmol Vis Sci
Zhao H, Xu Y, Feng P, Wang X, Chen B, Zhang L.   +5 more
europepmc   +1 more source

PPP1CC Suppresses Preadipocyte Differentiation in Chickens at Least Partly by Regulating NRF1 Expression. [PDF]

Genes (Basel)
Cui T, Zhang A, Zhang X, Yang Q, Chen H, Li X, Huang R, Zhang L, Zhang W.   +8 more
europepmc   +1 more source

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382. [PDF]

Cells
Das A, Yoshizawa T, Yamada D, Tsuyama T, Sato Y, Mizumoto T, Yoneshiro T, Kajimura S, Yamagata K.   +8 more
europepmc   +1 more source