Results 231 to 240 of about 101,448 (257)

Differential gene regulation by SR12813 and rifampicin: Insights into PXR and PPARγ activation and metabolic pathway modulation in LS180 colon cancer cells. [PDF]

Drug Metab Dispos
Brobst D, Hemsath J, Niewchas A, Pham C, Lamboglia B, Sawalha Y, Ballard C, Bodily R, Dye W, Nguyen V, Youssef A, Elliott C, Staudinger JL, Creamer BA.   +13 more
europepmc   +1 more source

Molecular subtype concordance and metastatic patterns in muscle‐invasive bladder cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.
Abstract Molecular subtypes are potential prognostic and predictive tools in muscle‐invasive bladder cancer (MIBC). However, subtype concordance between primary tumors and metastases, as well as subtype‐specific differences in metastatic patterns, remain poorly characterized.
Csilla Olah, Dániel Juhász, Melinda Váradi, Henning Reis, Mulham Al‐Nader, Osama Mahmoud, Barbara T. Grünwald, Viktor Grünwald, Boris Hadaschik, Péter Nyirády, Tibor Szarvas   +10 more
wiley   +1 more source

Shifting the PPARγ conformational ensemble toward a transcriptionally repressive state improves covalent inhibitor efficacy. [PDF]

Elife
Arifova L, MacTavish BS, Laughlin Z, Karadi Girdhar MN, Shang J, Li MH, Yu X, Zhu D, Kamenecka TM, Kojetin DJ.   +9 more
europepmc   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, Volume 16, Issue 5, Page 932-943, May 2026.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

A halogenated pregnenolone analogue suppresses HepG2 proliferation and induces apoptosis <i>via</i> PPARγ regulation. [PDF]

RSC Med Chem
Xu SY, Liu QX, Luo Y, Wu WH, Li Q, Liao SG, Ao JL, Xu GB.   +7 more
europepmc   +1 more source

Identification of Alzheimer's disease subtypes and biomarkers from human multi‐omics data using subspace merging algorithm

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a heterogeneous disease with diverse disease progression trajectories and brain pathology. Identifying AD subtypes is essential for understanding AD etiology, heterogeneity, and developing precise treatment. METHODS We applied a subspace‐merging algorithm to integrate multi‐omics data from brain tissues
Ziyan Song, Xiaoqing Huang, Asha Jacob Jannu, Travis S. Johnson, Jie Zhang, Kun Huang   +5 more
wiley   +1 more source

Palmitoleic Acid Loss Links Pulmonary Dysbiosis to Lung Injury After Single-Lung Ventilation. [PDF]

Am J Respir Cell Mol Biol
Najibi H, Li K, Yao C.
europepmc   +1 more source

Oncogenic driver and therapeutic target: Prolactin signalling axis in retroperitoneal sarcoma

Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.
Retroperitoneal sarcoma cells can secrete prolactin into the bloodstream, inducing hyperprolactinaemia, which subsequently triggers metabolic reprogramming, such as glucose metabolism. SOX4 can function as a transcription factor that facilitates PRL transcription.
Fu'an Xie, Lingwei Gu, Kunrong Yang, Shuai Wang, Mengmeng Xiao, Guangting Yan, Quan Zhang, Rubing Liang, Aobo Zhuang, Zhe Xi, Yujia Niu, Yanhua Chen, Xiaogang Xia, Linlin Qu, Bin Zhao, Weibing Li, Ting Wu, Chundong Yu, Chenghua Luo, Houzhao Wang, Lanlan Lian, Wengang Li   +21 more
wiley   +1 more source

Dietary conjugated linoleic acid enhances resistance to <i>Salmonella</i> infection by promoting PPARγ-mediated metabolic reprogramming and effector function in CD8⁺ T cells. [PDF]

Gut Microbes
Deng L, Wang X, Mebratie DY, Tang Y, Hu J, Qi J, Tian M, Bao Y, Zhu L, Wang S.   +9 more
europepmc   +1 more source

Ihmisen apolipoproteiinien ekspressio ja niiden säätely PPAR:llä [PDF]

Uski, Oskari
core