Results 241 to 250 of about 74,506 (264)

Residual bile flow shapes PPARγ-mediated antifibrotic responses in experimental segmental cholestasis. [PDF]

Sci Rep
Gonçalves JO, Mafra CAM, Castro I, Cogliati B, Bando SY, Teodoro WR, Serafini S, Ferreira LF, Moreira-Filho CA, Tannuri U, Tannuri ACA.   +10 more
europepmc   +1 more source

Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment

MedComm, Volume 7, Issue 7, July 2026.
Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui, Xiaxia Du, Felix Kwame Amevor, Yaoyao Xia, You Yang, Lingbin Liu   +5 more
wiley   +1 more source

B4GALT1 deficiency attenuates steatohepatitis by regulating the PPARγ/ACSL4 axis. [PDF]

Hepatol Commun
Chien Y, Xia R, Zhou D, Ai Y, Wu L, Zeng X, Chen S.   +6 more
europepmc   +1 more source

Osteoarthritis: Epidemiology, Diagnosis, and Treatment

MedComm, Volume 7, Issue 7, July 2026.
Osteoarthritis (OA) is a multifactorial degenerative joint disease and a leading cause of disability worldwide. This graphical abstract summarizes the epidemiology, diagnostic strategies, and therapeutic approaches of OA. OA development is driven by aging, metabolic dysregulation, and mechanical stress, leading to progressive joint degeneration ...
Qin Ru, Dongliang Yuan, Shide Jiang, Xiaoxuan Zhao, Xu Liu, Yusheng Li, Shuguang Liu, Yuxiang Wu   +7 more
wiley   +1 more source

Curcumin and ferulic acid activate PPARγ-PGC1α signaling and improve mitochondrial function in a 6-OHDA-induced Parkinson's cellular model. [PDF]

Sci Rep
Hassani S, Tashakkor Z, Esmaeili A, Ghaedi K.   +3 more
europepmc   +1 more source

Epilepsy: Epidemiology, Molecular Pathogenesis, and Clinical Management

MedComm, Volume 7, Issue 7, July 2026.
Epilepsy is a heterogeneous and chronically evolving brain network disorder. This review integrates epidemiological burden, psychiatric comorbidities, and cyclic seizure patterns with multiscale pathogenic mechanisms, including ion‐channel dysfunction, synaptic transmission defects, neuroinflammation, metabolic and mitochondrial dysfunction, and ...
Jian Liu, Xinyan Wu, Ting Yin, Feining Huang, Manqi Kong, Yu Yang, Zinan Liu, Jiabin Yu, Tianpeng Zhang   +8 more
wiley   +1 more source

An aerosolized dual-action autotaxin inhibitor-PPARγ agonist for the treatment of pulmonary fibrosis. [PDF]

Cell Rep Med
Matralis AN, Stylianaki EA, Ladopoulou EM, Kanellopoulou P, Smyrniotis S, Magkrioti C, Papavasileiou KD, Willems S, Rincon Pabon JP, Nastos D, Galaras A, Moro C, Dedos SG, Kaffe E, Hatzis P, Osman-Ponchet H, Merk D, Politis A, Afantitis A, Tseti I, Antoniou KM, Wells AU, Aidinis V.   +22 more
europepmc   +1 more source

Tucum‐do‐Cerrado (Bactris setosa Mart.) Consumption Promoted a Healthier Expansion of Adipose Tissue in High‐Fat Diet‐Induced Obesity Rats

Molecular Nutrition &Food Research, Volume 70, Issue 13, 15 July 2026.
ABSTRACT Tucum‐do‐Cerrado (Bactris setosa Mart.) is a polyphenol‐rich Brazilian fruit known to improve glucose metabolism. This study investigated its effects on brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues in a diet‐induced obesity model. Rats received control (CT/TUC‐), high‐fat (HF/TUC‐), control with Tucum‐do‐Cerrado (CT/TUC+)
Marilia Hermes Cavalcanti, Amílcar Sabino Damazo, Sandra Fernandes Arruda   +2 more
wiley   +1 more source

Endothelial Cells as Active Lipid Gatekeepers: Vascular Control of Lipid Handling and Metabolic Homeostasis. [PDF]

Nutrients
Kanda T, Urai H.
europepmc   +1 more source

The Lipid Droplet–Associated Hydrolase Is Associated With Obesity and Adipose Tissue Inflammation in Children

Obesity, Volume 34, Issue 7, Page 1420-1432, July 2026.
ABSTRACT Objective The lipid droplet–associated hydrolase (LDAH) is a lipid droplet–associated protein with an uncharacterized role in human adipose tissue (AT) and obesity; we aimed to investigate its role in human AT and its relevance for childhood obesity.
Claudia Vales‐Villamarín, Antje Berthold, Martin Lacher, Antje Körner, Kathrin Landgraf   +4 more
wiley   +1 more source