Results 241 to 250 of about 101,448 (257)

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Hepatoprotective Effects of Fused Pyridine Derivatives: Regulation of the TGF-β/Smad, miR-21/Smad7, and PPARγ Pathways in Carbon Tetrachloride-Induced Liver Fibrosis. [PDF]

Drug Des Devel Ther
Khalil MM, Elhamammy RH, Ragab HM, Abdelgalil MH, Sheta E, Elaraby AR, Ibrahim TM, Wahid A.   +7 more
europepmc   +1 more source

Interaction and Joint Effects of Inflammation and Triglyceride–Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross‐Sectional Study

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
Among 5307 southern Chinese adults, higher TyG index and mINFLA score were associated with increased HUA risk and serum UA levels (p trend < 0.001). A significant interaction was observed between these two indicators. Notably, the TyG index mediated 15.4% of the mINFLA‐HUA association and 14.5% of the mINFLA‐UA association.
Xueran Huang, Pengfei Chen, Yongfen Gao, Zengnan Mo, Haiying Zhang, Rui Lin   +5 more
wiley   +1 more source

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review). [PDF]

Int J Mol Med
Cui MW, Tao SY, Wen T, Guo ZL.
europepmc   +1 more source

Fungal Polysaccharides as Next‐Generation Bioactive: Advances in Structure–Activity Mapping, Mode of Action, and Biotechnological Horizons

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Fungal polysaccharides (FPs) represent a diverse class of bioactive macromolecules widely studied for their nutritional, therapeutic, and biotechnological value. This review synthesizes recent advances (2020–2025) in the structural characterization, biological functions, and translational potential of FPs.
Muhammad Aaqil, Feng Zhang, Jingchuan Zheng, Muhammad Kamil, Yuwei Guo, Cunchao Zhao, Yang Tian   +6 more
wiley   +1 more source

Cardiovascular Benefits of Salvia miltiorrhiza (Danshen) Supplementation: Bioactive Constituents, Mechanisms, Clinical Evidence and Implications for Nutritional Care

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Salvia miltiorrhiza (Danshen) contains bioactive tanshinones, including tanshinone IIA, cryptotanshinone, and tanshinone I, that exert cardioprotective effects through coordinated modulation of vascular endothelial growth factor receptor (VEGFR), transforming growth factor beta 1 (TGF‐β1), transforming growth factor beta receptor (TGF‐βR), toll‐like ...
Akash Vikal, Rashmi Maurya, Preeti Patel, Balak Das Kurmi, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +6 more
wiley   +1 more source

Baicalin as a Regulator of Peroxisome Proliferator-Activated Receptor Gamma: Alleviating Sepsis-Induced Liver Injury by Inhibiting the Cluster of Differentiation 14/Nuclear Factor Kappa B Signaling Pathway. [PDF]

Immun Inflamm Dis
Wang H, Guo M, Zeng X, Hu Y, Ma J, Chang Y.   +5 more
europepmc   +1 more source

The Influence of the <i>FGF8</i> Gene on the Proliferation and Differentiation of Preadipocytes in Sheep. [PDF]

Animals (Basel)
Han W, Zhang H, Gao F, Tian L, He Z, Wang G, Zhang S, Di T, Chang M, Li S, Zhao F, Yang G.   +11 more
europepmc   +1 more source

Nuclear receptor-driven immunometabolic crosstalk: immune-centric pharmacology targeting the inflamed nexus. [PDF]

Front Cell Dev Biol
Zhang Y, Pei Z, Wen Z, Chen Y, Wang H, Tan W, Chen X, Liu J, Ni Q.   +8 more
europepmc   +1 more source

Lathyrol Exerts Anti-Pulmonary Fibrosis Effects by Activating PPARγ to Inhibit the TGF-β/Smad Pathway. [PDF]

Int J Mol Sci
Zeng Q, Liao ML, Luo YY, Li S, You G, Huang CM, Liu MH, Liu W, Tang SY.   +8 more
europepmc   +1 more source