Results 101 to 110 of about 76,534 (232)

The peroxisome proliferator-activated receptor (PPAR) alpha agonist fenofibrate maintains bone mass, while the PPAR gamma agonist pioglitazone exaggerates bone loss, in ovariectomized rats [PDF]

, 2011
Astrid Kamilla Stunes, Irene Westbroek, Björn Gustafsson, Reidar Fossmark, J.H. Waarsing, Erik Fink Eriksen, Christiane Petzold, Janne E. Reseland, Unni Syversen   +8 more
openalex   +1 more source

GW9662, an antagonist of PPAR-gamma, inhibits breast tumour cell growth and promotes the anticancer effects of the PPAR-gamma agonist Rosiglitazone, independently of PPAR-gamma activation.

, 2004
No Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily, is activated by several compounds, including the thiazolidinediones. In addition to being a therapeutic target for obesity, hypolipidaemia and diabetes, perturbation of PPARgamma signalling is now believed to be a strategy for treatment of ...
Gill, Jason H., Seargent, Jill M., Yates, Elisabeth A.   +2 more
openaire   +2 more sources

Anti-Diabetic Effect of Telmisartan Through its Partial PPARγ-Agonistic Activity

Diabetes, Metabolic Syndrome and Obesity, 2020
Muluken Altaye Ayza, Kaleab Alemayehu Zewdie, Bekalu Amare Tesfaye, Selamawit Tesfamariam Gebrekirstos, Derbew Fikadu Berhe Department of Pharmacology and Toxicology, School of Pharmacy, Mekelle University, Mekelle, EthiopiaCorrespondence: Muluken Altaye
Ayza MA, Zewdie KA, Tesfaye BA, Gebrekirstos ST, Berhe DF   +4 more
doaj  

PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients. [PDF]

Front Pharmacol, 2023
Di Donfrancesco A, Berlingieri C, Giacomello M, Frascarelli C, Magalhaes Rebelo AP, Bindoff LA, Reeval S, Renbaum P, Santorelli FM, Massaro G, Viscomi C, Zeviani M, Ghezzi D, Bottani E, Brunetti D.   +14 more
europepmc   +1 more source

Hypothalamic orexin A expression and the involvement of AMPK and PPAR-gamma signalling in energy restricted dairy cows [PDF]

, 2011
B. Kuhla, Solvig Görs, Cornelia C. Metges   +2 more
openalex   +1 more source

PPAR-Gamma Orchestrates EMT, AGE, and Cellular Senescence Pathways in Colonic Epithelium and Restrains the Progression of IBDs. [PDF]

Int J Mol Sci, 2023
Pompili S, Vetuschi A, Latella G, Smakaj A, Sferra R, Cappariello A.   +5 more
europepmc   +1 more source

The Role of PPARgamma in the Cyclooxygenase Pathway in Lung Cancer. [PDF]

, 2008
Decreased expression of peroxisome proliferator activated receptor-gamma (PPARgamma) and high levels of the proinflammatory enzyme cyclooxygenase-2 (COX-2) have been observed in many tumor types.
Dubinett, Steven M, Hazra, Saswati, Mao, Jenny T, Peebles, Katherine A, Sharma, Sherven   +4 more
core  

Molecular Characterization of PGC-1β (PPAR Gamma Coactivator 1β) and its Roles in Mitochondrial Biogenesis in Blunt Snout Bream (Megalobrama amblycephala) [PDF]

, 2020
Kangle Lu, Tomáš Policar, Xiaojun Song, Samad Rahimnejad   +3 more
openalex   +1 more source

Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents

Acta Biochimica Indonesiana
Background: Diabetes mellitus remains one of the most dangerous illnesses worldwide. The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy.
Anjar Hermadi Saputro, Riri Fauziyya, Sarmoko, Iwan Syahjoko Saputra   +3 more
doaj   +1 more source

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma. [PDF]

Gut, 2023
Xiong Z, Chan SL, Zhou J, Vong JSL, Kwong TT, Zeng X, Wu H, Cao J, Tu Y, Feng Y, Yang W, Wong PP, Si-Tou WW, Liu X, Wang J, Tang W, Liang Z, Lu J, Li KM, Low JT, Chan MW, Leung HHW, Chan AWH, To KF, Yip KY, Lo YMD, Sung JJ, Cheng AS.   +27 more
europepmc   +1 more source