Results 111 to 120 of about 41,660 (152)

Ppar-Gamma Effects on the Vasculature

Journal of Investigative Medicine, 2001
The peroxisome proliferator activated receptor, PPAR-gamma, is a potential protective factor in vascular injury. This receptor is becoming more important in medicine. Ligands to these receptors are now being administered to diabetic patients, because they function as insulin sensitizers.
openaire   +2 more sources

PPAR(gamma) and glucose homeostasis.

Annual review of nutrition, 2002
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor involved in the control of metabolism. Research on PPARgamma is oriented towards understanding its role in insulin sensitization, which was inspired by the discovery that antidiabetic agents, the thiazolidinediones, were agonists for PPARgamma.
Picard, Frédéric, Auwerx, Johan
openaire   +4 more sources

The Clinical Significance of PPAR Gamma Agonism

Current Molecular Medicine, 2005
Insulin resistance is a principal underlying defect in type 2 DM along with beta-cell dysfunction, and this insulin resistance underpins many of the abnormalities associated with the metabolic syndrome. Peroxisome-proliferator-activated receptor gamma agonists (PPARgamma agonists), also known as glitazones or thiazolidinediones (TZDs) are powerful ...
openaire   +2 more sources

PPAR gamma and the control of adipogenesis.

Biochimie, 1997
We recently cloned PPAR gamma as a factor that binds to an enhancer which has specificity for adipose cells. When expressed ectopically, PPAR gamma converts fibroblasts into bona fide preadipose cells. Upon application of activators or PPAR gamma ligands, these cells differentiate into fat cells.
B M, Spiegelman, E, Hu, J B, Kim, R, Brun   +3 more
openaire   +1 more source

Phosphorylation of PPAR gamma Affects the Collective Motions of the PPAR gamma-RXR alpha-DNA Complex

2016
National Science ...
Lemkul, Justin A., Lewis, Stephanie N., Bassaganya-Riera, Josep, Bevan, David R.   +3 more
openaire   +1 more source

PPAR-gamma agonists: Potential modulators of autophagy in obesity

European Journal of Pharmacology, 2021
Mohammadreza Alivand, Amir Hossein Faghfouri, Yaser Khajebishak   +2 more
exaly  

Role of Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Different Disease States: Recent Updates

Current Medicinal Chemistry, 2021
Naveen Kumar
exaly  

PPAR gamma and the molecular control of adipogenesis

Journal of Endocrinology, 1997
R P, Brun, B M, Spiegelman
openaire   +2 more sources

PPAR gamma: an essential role in metabolic control.

Nutrition, metabolism, and cardiovascular diseases : NMCD, 2001
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands.
Fajas, L., Debril, M.-B., Auwerx, Johan
openaire   +2 more sources

GW9662, an antagonist of PPAR-gamma, inhibits breast tumour cell growth and promotes the anticancer effects of the PPAR-gamma agonist Rosiglitazone, independently of PPAR-gamma activation.

2009
Peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily, is activated by several compounds, including the thiazolidinediones. In addition to being a therapeutic target for obesity, hypolipidaemia and diabetes, perturbation of PPARgamma signalling is now believed to be a strategy for treatment of ...
Gill, Jason H., Seargent, Jill M., Yates, Elisabeth A.   +2 more
openaire   +2 more sources