Results 191 to 200 of about 76,534 (232)
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Fatty acids, eicosanoids and PPAR gamma
European Journal of Pharmacology, 2016Peroxisome proliferator-activated receptor γ (PPARγ) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine. Contrary to other nuclear receptors that mainly bind a single specific ligand, there are numerous natural PPARγ ligands, in particular fatty acids or their ...
Rachel Marion-Letellier, Subrata Ghosh
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Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 2015
Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. There have been described three PPAR isotypes α, δ and γ which have an integrated role in controlling the expression of genes playing key ...
C, Janani, B D, Ranjitha Kumari
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Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense research because ligands for this receptor have emerged as potent insulin sensitizers used in the treatment of type 2 diabetes. There have been described three PPAR isotypes α, δ and γ which have an integrated role in controlling the expression of genes playing key ...
C, Janani, B D, Ranjitha Kumari
exaly +3 more sources
European Journal of Immunology, 2001
Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that serves as a trans factor to regulate lipid metabolism. Intense interest is focused on PPAR-gamma and its ligands owing to its putative role in adipocyte differentiation.
Richard P Phipps
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Peroxisome proliferator-activated receptor (PPAR)-gamma is a nuclear hormone receptor that serves as a trans factor to regulate lipid metabolism. Intense interest is focused on PPAR-gamma and its ligands owing to its putative role in adipocyte differentiation.
Richard P Phipps
exaly +3 more sources
The role of PPAR-gamma receptor in pruritus
European Journal of Pharmacology, 2015Recent studies have clarified the novel mediators and neuronal pathways involved in itch transmission, which might result in introduction of new therapies for management of pruritus in the near future. Involvement of peroxisome proliferator-activated receptor (PPAR) signaling in the pathogenesis of skin diseases was suggested in recent experiments ...
Sattar, Ostadhadi +4 more
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Ppar-Gamma Effects on the Vasculature
Journal of Investigative Medicine, 2001The peroxisome proliferator activated receptor, PPAR-gamma, is a potential protective factor in vascular injury. This receptor is becoming more important in medicine. Ligands to these receptors are now being administered to diabetic patients, because they function as insulin sensitizers.
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The Clinical Significance of PPAR Gamma Agonism
Current Molecular Medicine, 2005Insulin resistance is a principal underlying defect in type 2 DM along with beta-cell dysfunction, and this insulin resistance underpins many of the abnormalities associated with the metabolic syndrome. Peroxisome-proliferator-activated receptor gamma agonists (PPARgamma agonists), also known as glitazones or thiazolidinediones (TZDs) are powerful ...
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PPAR(gamma) and glucose homeostasis.
Annual review of nutrition, 2002Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor involved in the control of metabolism. Research on PPARgamma is oriented towards understanding its role in insulin sensitization, which was inspired by the discovery that antidiabetic agents, the thiazolidinediones, were agonists for PPARgamma.
Picard, Frédéric, Auwerx, Johan
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Hybridoma, 1999
Troglitazone and rosiglitazone (BRL49653), members of the thiazolidinedione (TZD) class of antidiabetic drugs, are peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that induce adipocyte differentiation and increase the expression of PPARgamma protein.
J L, Su +4 more
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Troglitazone and rosiglitazone (BRL49653), members of the thiazolidinedione (TZD) class of antidiabetic drugs, are peroxisome proliferator-activated receptor gamma (PPARgamma) ligands that induce adipocyte differentiation and increase the expression of PPARgamma protein.
J L, Su +4 more
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PPAR gamma and the control of adipogenesis.
Biochimie, 1997We recently cloned PPAR gamma as a factor that binds to an enhancer which has specificity for adipose cells. When expressed ectopically, PPAR gamma converts fibroblasts into bona fide preadipose cells. Upon application of activators or PPAR gamma ligands, these cells differentiate into fat cells.
B M, Spiegelman +3 more
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Phosphorylation of PPAR gamma Affects the Collective Motions of the PPAR gamma-RXR alpha-DNA Complex
2016National Science ...
Lemkul, Justin A. +3 more
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