Results 171 to 180 of about 14,528 (201)
Broad-spectrum tolerance to disinfectant-mediated bacterial killing due to mutation of the PheS aminoacyl tRNA synthetase. [PDF]
Proc Natl Acad Sci U S AChen M +14 more
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Gene Expression Depends on the Interplay Among Growth, Resource Biogenesis, and Nutrient Quality. [PDF]
ACS Synth BiolKim J +10 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Abstract The chemical synthesis of ppGpp (guanosine 3′,5′-dipyrophosphate) is described. The synthesis started from guanosine 3′,5′-diphosphate. The acidlabile ethoxyethyl group was used to protect the 2′-OH functional group. The pyrophosphate linkages were built up simultaneously according to the anionexchange method and the protecting group was ...
A, Simoncsits, J, Tomasz
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Stringency without ppGpp accumulation
Nature, 1981Wild-type Escherichia coli deprived of a required amino acid shows a stringent response involving various alterations in the cell's normal physiology, including the arrest of net synthesis of stable (ribosomal and transfer) RNA, lipids, phospholipids and peptidoglycans1.
A, Spadaro +3 more
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Journal of Cellular Physiology, 2009
AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
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AbstractGuanosine 5′‐(tri)diphosphate, 3′‐diphosphate [(p) ppGpp] is a small nucleic acid that helps bacteria survive in limited environments. Gene chip shows that (p) ppGpp is a global transcription‐regulator of genes related to important bacterial metabolic processes.
Jun, Wu, Jianping, Xie
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ppGpp cycle in Escherichia coli
Molecular and General Genetics MGG, 1977Kinetics of accumulation and degradation of ppGpp and pppGpp were analysed in spoT+ and spoT strains of Escherichia coli. The experimental data in this paper indicate that on degradation ppGpp is not converted to pppGpp but instead is converted to GDP which is in turn phosphorylated to GTP.
C, Kari, I, Török, A, Travers
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Journal of Cellular Physiology, 2010
AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
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AbstractIn recent years, emerging and reemerging pathogens resistant to nearly all available antibiotics are on the rise. This limits the availability of effective antibiotics to treat infections, thus it is imperative to develop new drugs. The accumulation of alarmones guanosine tetraphosphate and guanosine pentaphosphate, collectively known as (p ...
Jun, Wu, Quanxin, Long, Jianping, Xie
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ppGpp: magic beyond RNA polymerase
Nature Reviews Microbiology, 2012During stress, bacteria undergo extensive physiological transformations, many of which are coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by redirecting the RNA polymerase (RNAP) to certain genes, it also acts as a signal in many other cellular processes in bacteria. After a brief overview of ppGpp biosynthesis and
Zachary D, Dalebroux, Michele S, Swanson
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Glyphosate induces the synthesis of ppGpp
Molecular Genetics and Genomics, 2018Glyphosate, the most widely used herbicide in both agricultural and urban areas is toxic for plants and for many bacterial species. The mechanism of action of glyphosate is through the inhibition of the EPSP synthase, a key enzyme in the biosynthetic pathway of aromatic amino acids.
Gabriela Torres Cruvinel +2 more
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ppGpp: a global regulator in Escherichia coli
Trends in Microbiology, 2005The small nucleotide ppGpp acts as a global regulator of gene expression in bacteria. Proteomic analysis of cells lacking ppGpp has shown that this nucleotide might affect many more genes than previously anticipated. These findings and others suggest that ppGpp causes a redirection of transcription so that genes important for starvation survival and ...
Lisa U, Magnusson +2 more
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