Results 21 to 30 of about 7,127 (231)

High‐resolution insights into binding of unfolded polypeptides by the PPIase chaperone SlpA

The FASEB Journal, 2012
SlpA is a 2‐domain protein consisting of an FK506‐binding protein (FKBP) domain that harbors the peptidyl‐prolyl cis / trans ‐isomerase (PPIase) active site and a small insert‐in‐flap (IF) domain that endows the protein with chaperone activity.
E. Quistgaard, P. Nordlund, Christian Löw   +2 more
semanticscholar   +5 more sources

PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism.

Journal of Biological Chemistry, 1992
FK506-binding protein (FKBP) catalyzes the cis-trans isomerization of the peptidyl-prolyl amide bond (the PPIase reaction) and is the major intracellular receptor for the immunosuppressive drugs FK506 and rapamycin.
Steve Park, R. Aldape, O. Futer, M. Decenzo, David J. Livingston   +4 more
semanticscholar   +3 more sources

Human Cyclophilins-An Emerging Class of Drug Targets. [PDF]

Med Res Rev
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Jurkova K, Navratilova H, Musilek K, Benek O.   +3 more
europepmc   +2 more sources

Crystal structure and biophysical characterisation of the enterococcal foldase PpiC, a cross-opsonic antigen against gram-positive nosocomial pathogens. [PDF]

FEBS J
PpiC is an enterococcal lipoprotein endowed with both Peptidyl‐prolyl cis‐trans isomerase (PPIase) and foldase activities. It is a potential target for novel antimicrobials and a promising vaccine antigen. We determined the crystal structure of the enzyme, showing that PpiC adopts a dimeric organisation embedding two catalytic parvulin‐type PPIase ...
Napolitano V, Kramarska E, Ghilardi O, Romero-Saavedra F, Del Vecchio P, Squeglia F, Huebner J, Berisio R.   +7 more
europepmc   +2 more sources

Assessing Trans-Inhibition of OATP1B1 and OATP1B3 by Calcineurin and/or PPIase Inhibitors and Global Identification of OATP1B1/3-Associated Proteins

Pharmaceutics, 2023
Organic anion transporting polypeptide (OATP) 1B1 and OATP1B3 are key determinants of drug–drug interactions (DDIs). Various drugs including the calcineurin inhibitor (CNI) cyclosporine A (CsA) exert preincubation-induced trans-inhibitory effects upon ...
John T Powell, R. Kayesh, Alexandra Ballesteros-Perez, Khondoker Alam, Pascaline Niyonshuti, Erik J. Soderblom, Kai Ding, Chao Xu, Wei Yue   +8 more
semanticscholar   +1 more source

The Actin-Binding Prolyl-Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery. [PDF]

Proteins
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Sternberg A, Borger JL, Thies M, Matena A, Blueggel M, Kamba BE, Beuck C, Kaschani F, Kaiser M, Bayer P.   +9 more
europepmc   +2 more sources

The HBV Core Protein and Core Particle Both Bind to the PPiase Par14 and Par17 to Enhance Their Stabilities and HBV Replication

Frontiers in Microbiology, 2021
We recently reported that the PPIase Par14 and Par17 encoded by PIN4 upregulate HBV replication in an HBx-dependent manner by binding to conserved arginine–proline (RP) motifs of HBx.
Umar Saeed, Z. Piracha, Hyeonjoong Kwon, Jumi Kim, F. Kalsoom, Y. Chwae, Sun Park, Ho-Joon Shin, Hyun Woong Lee, J. Lim, Kyongmin Kim   +10 more
semanticscholar   +1 more source

Structural insights into Plasmodium PPIases

Frontiers in Cellular and Infection Microbiology, 2022
Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets. It is a well-known practice to adopt a chemo-genomics approach towards identifying targets for known drugs, which can unravel a novel ...
Sreekanth Rajan, Ho Sup Yoon, Ho Sup Yoon, Ho Sup Yoon   +3 more
openaire   +4 more sources

Cyclophilin A Inhibits Human Respiratory Syncytial Virus (RSV) Replication by Binding to RSV-N through Its PPIase Activity

Journal of Virology, 2021
RSV-N, packed in the viral genome to form the ribonucleoprotein (RNP) complex, which is recognized by the RSV RNA-dependent RNA polymerase (RdRp) complex to initiate viral replication and transcription, plays an indispensable role in the viral ...
Wenzhang Liang, Yue Zhang, Miao Li, Fadhl Al-Shaebi, Jian Li, Jing Zhang, Lin Wei   +6 more
semanticscholar   +1 more source

Cyclophilin D: Guardian or Executioner for Tumor Cells?

Frontiers in Oncology, 2022
Cyclophilin D (CypD) is a peptide-proline cis-trans isomerase (PPIase) distributed in the mitochondrial matrix. CypD regulates the opening of the mitochondrial permeability conversion pore (mPTP) and mitochondrial bioenergetics through PPIase activity or
Ling Zhang, Yi Liu, Yi Liu, Rou Zhou, Baoyu He, Wenjun Wang, Bin Zhang, Bin Zhang   +7 more
doaj   +1 more source