Results 41 to 50 of about 7,127 (231)

Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma. [PDF]

PLoS ONE, 2015
Cyclophilin J (CYPJ) is a new member of the peptidyl-prolyl cis/trans-isomerase (PPIase) identified with upregulated expression in human glioma. However, the biological function of CYPJ remained unclear.
Jian Chen, Shuai Chen, Jiahui Wang, Mingjun Zhang, Zhaohua Gong, Youheng Wei, Li Li, Yuanyuan Zhang, Xuemei Zhao, Songmin Jiang, Long Yu   +10 more
doaj   +1 more source

Roles of peptidyl prolyl isomerase Pin1 in viral propagation

Frontiers in Cell and Developmental Biology, 2022
Peptidyl-prolyl isomerase (PPIase) is a unique enzyme that promotes cis-trans isomerization of a proline residue of a target protein. Peptidyl-prolyl cis-trans isomerase NIMA (never in mitosis A)-interacting 1 (Pin1) is a PPIase that binds to the pSer ...
Machi Kanna, Yusuke Nakatsu, Takeshi Yamamotoya, Jeffrey Encinas, Hisanaka Ito, Takayoshi Okabe, Tomoichiro Asano, Takemasa Sakaguchi   +7 more
doaj   +1 more source

Complete Determination of the Pin1 Catalytic Domain Thermodynamic Cycle by NMR Lineshape Analysis [PDF]

, 2011
The phosphorylation-specific peptidyl-prolyl isomerase Pin1 catalyzes the isomerization of the peptide bond preceding a proline residue between cis and trans isomers.
De, Soumya, Greenwood, Alexander I., Kovriguine, Evgueni, Lu, Kun Ping, Nicholson, Linda K., Rogals, Monique J.   +5 more
core   +2 more sources

Cyclohexyl ketone inhibitors of Pin1 dock in a trans-diaxial cyclohexane conformation. [PDF]

PLoS ONE, 2012
Cyclohexyl ketone substrate analogue inhibitors (Ac-pSer-Ψ[C = OCH]-Pip-tryptamine) of Pin1, the cell cycle regulatory peptidyl-prolyl isomerase (PPIase), were designed and synthesized as potential electrophilic acceptors for the Pin1 active site Cys113 ...
Guoyan G Xu, Carla Slebodnick, Felicia A Etzkorn   +2 more
doaj   +1 more source

Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition

Virulence, 2023
Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic pathogen found in humans and pigs, can cause severe clinical infections, and pose public health issues.
Xiaowu Jiang, Guijun Yu, Lexin Zhu, Abubakar Siddique, Dongbo Zhan, Linhua Zhou, Min Yue   +6 more
doaj   +1 more source

Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila

Frontiers in Bioengineering and Biotechnology, 2015
Mip (macrophage infectivity potentiator) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases ...
Janine eRasch, Martin eTheuerkorn, Can eÜnal, Can eÜnal, Natascha eHeinsohn, Stefan eTran, Gunter eFischer, Gunter eFischer, Matthias eWeiwad, Matthias eWeiwad, Michael eSteinert, Michael eSteinert   +11 more
doaj   +1 more source

Peptidyl-prolyl cis-trans isomerases (immunophilins) and their roles in parasite biochemistry, host-parasite interaction and antiparasitic drug action. [PDF]

, 2006
Immunophilin is the collective name given to the cyclophilin and FK506-binding protein (FKBP) families. As the name suggests, these include the major binding proteins of certain immunosuppressive drugs: cyclophilins for the cyclic peptide cyclosporin A ...
Adams, Aliberti, Alphey, Angus Bell, Antony P. Page, Argaet, Banerjee, Banumathy, Belfiore, Bell, Bell, Bell, Berriman, Blumenthal, Blumenthal, Borel, Bozdech, Braun, Bua, Carlton, Chakraborty, Chakraborty, Chappell, Chappell, Cianciotto, Cohen, Colgan, Dao-Thi, Denkers, Dobson, Dolinski, Dornan, Dornan, Dutta, Fischer, Florens, Galat, Galat, Gavigan, Gavigan, Gilleard, Golding, Hacker, Hall, High, Hirtzlin, Hong, Hope, Kamath, Kay, Ke, Khattab, Kiang, Klinkert, Klinkert, Knobloch, Kumar, Kumar, Kumar, Le Roch, Lightowlers, Lorberg, Ma, Ma, Ma, Matsuda, McLauchlan, Mikol, Monaghan, Monaghan, Moro, Osman, Ostoa-Saloma, Oz, Page, Page, Page, Page, Page, Page, Page, Paul Monaghan, Pelle, Pereira, Peterson, Picken, Pratt, Rascher, Reddy, Riggs, Rossi, Shirane, Silverman, Taylor, Tuo, Valle, Wang, Weiwad, Williams, Yarovinsky, Yu, Zorio   +101 more
core   +1 more source

Molecular and Biochemical Characterization of the Parvulin-Type PPIases in Lotus japonicus         [PDF]

Plant Physiology, 2009
Abstract The cis/trans isomerization of the peptide bond preceding proline is an intrinsically slow process, although important in many biological processes in both prokaryotes and eukaryotes. In vivo, this isomerization is catalyzed by peptidyl-prolyl cis/trans-isomerases (PPIases).
Kouri, Evangelia D., Labrou, Nikolaos E., Garbis, Spiros D., Kalliampakou, Katerina I., Stedel, Catalina, Dimou, Maria, Udvardi, Michael K., Katinakis, Panagiotis, Flemetakis, Emmanouil   +8 more
openaire   +3 more sources

Mutational effects of Cys113 on structural dynamics of Pin1

Biophysics and Physicobiology, 2019
Pin1 is a peptidyl-prolyl isomerase (PPIase) which catalyzes cis/trans isomerization of pS/pT-P bond. Its activity is related to various cellular functions including suppression of Alzheimer’s disease. A cysteine residue C113 is known to be important for
Teikichi Ikura, Yasushige Yonezawa, Nobutoshi Ito   +2 more
doaj   +1 more source

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State [PDF]

, 2016
The mitochondrial thioredoxin system (NADPH, thioredoxin reductase, thioredoxin) is a major redox regulator. Here we have investigated the redox correlation between this system and the mitochondrial enzyme cyclophilin D.
Bindoli, Alberto, Cali', Tito, Citta, Anna, Folda, Alessandra, Rigobello, MARIA PIA, Scalcon, Valeria, Scutari, Guido, Zonta, Francesco   +7 more
core   +1 more source