Results 81 to 90 of about 7,127 (231)

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Molecular Evolution of the Vertebrate FK506 Binding Protein 25

International Journal of Genomics, 2014
FK506 binding proteins (FKBPs) belong to immunophilins with peptidyl-prolyl isomerases (PPIases) activity. FKBP25 (also known as FKBP3) is one of the nuclear DNA-binding proteins in the FKBPs family, which plays an important role in regulating ...
Fei Liu, Xiao-Long Wei, Hao Li, Ji-Fu Wei, Yong-Qing Wang, Xiao-Jian Gong   +5 more
doaj   +1 more source

Comprehensive Analysis of Malate Accumulation in Peaches in Response to Cold Stress Based on Transcriptomics

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
This study explored malate‐accumulation mechanisms in “Hujingmilu” peaches under different storage conditions. Low temperature (LT) delayed firmness decline and maintained higher malate. Transcriptomics showed malate biosynthetic genes weakly correlate with malate levels, while proton pump and transporter genes were up‐regulated under LT.
Hongfang Cai, Shuai Han, Xu Wang, Jiqing Shi, Zewen Xiong, Zheng Zhang, Zhuyi Gao   +6 more
wiley   +1 more source

Emergence of Francisella novicida Bacteremia, Thailand

Emerging Infectious Diseases, 2008
We report isolation of Francisella novicida–causing bacteremia in a woman from Thailand who was receiving chemotherapy for ovarian cancer. The organism was isolated from blood cultures and identified by 16S rDNA and PPIase gene analyses.
Amornrut Leelaporn, Samaporn Yongyod, Sunee Limsrivanichakorn, Thitiya Yungyuen, Pattarachai Kiratisin   +4 more
doaj   +1 more source

FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth

Cell Reports, 2020
Summary: Cancer therapy is limited, in part, by lack of specificity. Thus, identifying molecules that are selectively expressed by, and relevant for, cancer cells is of paramount medical importance. Here, we show that peptidyl-prolyl-cis-trans-isomerase (
Giorgio Ramadori, Rafael M. Ioris, Zoltan Villanyi, Raquel Firnkes, Olesya O. Panasenko, George Allen, Georgia Konstantinidou, Ebru Aras, Xavier Brenachot, Tommasina Biscotti, Anne Charollais, Michele Luchetti, Fedor Bezrukov, Alfredo Santinelli, Muntaha Samad, Pierre Baldi, Martine A. Collart, Roberto Coppari   +17 more
doaj   +1 more source

Membrane‐forming phospholipids allosterically modulate native‐state prolyl isomerization in a CNG channel

Protein Science, Volume 34, Issue 12, December 2025.
Abstract Ion channel activity is intricately linked to the surrounding lipid environment, yet the molecular effects of lipid‐mediated regulation remain largely understudied. Here, we show that membrane‐forming phospholipids, which are known to modulate the activity of the cyclic nucleotide‐gated channel SthK from Spirochaeta thermophila, exhibit ...
Ashley J. Newton, Robert D. Latvala, Adefoluke E. Kuforiji, Philipp A. M. Schmidpeter   +3 more
wiley   +1 more source

Rapid proteasomal degradation of mutant proteins is the primary mechanism leading to tumorigenesis in patients with missense AIP mutations [PDF]

, 2016
CONTEXT The pathogenic effect of AIP mutations (AIPmuts) in pituitary adenomas is incompletely understood. We have identified the primary mechanism of loss of function for missense AIPmuts.
D'Acquisto, Fulvio, Hernández-Ramírez, Laura C, Iacovazzo, Donato, Korbonits, Márta, Martucci, Federico, Morgan, Rhodri M L, Prodromou, Chrisostomos, Ramos-Guajardo, Nancy, Tilley, Daniel, Trivellin, Giampaolo   +9 more
core   +2 more sources

Engineering Pt Single‐Atom Doped SeS2/Ti3CNTx MXene with Molecularly Imprinted Polymer for Precision Pancreatic Cancer Diagnostics: DFT and Molecular Dynamics Perspectives

Small Methods, Volume 9, Issue 12, December 1, 2025.
A novel approach is developed to pancreatic cancer screening by targeting the cyclophili‐B (CypB)protein using a molecularly imprinted polymer with the electrode material containing Pt single‐atom‐doped/SeS2‐Ti3CNTx MXene. The quantification of CypB in pancreatic cancer tissues provide an insight into the association of CypB with pancreatic cancer ...
Sathish Panneer Selvam, Shanmugasundaram Kamalakannan, Agalya Mathivanan, Sungbo Cho   +3 more
wiley   +1 more source

The cyclophilin A DIAGEOTROPICA gene affects auxin transport in both root and shoot to control lateral root formation [PDF]

, 2015
Cyclophilin A is a conserved peptidyl-prolyl cis-trans isomerase (PPIase) best known as the cellular receptor of the immunosuppressant cyclosporine A. Despite significant effort, evidence of developmental functions of cyclophilin A in non-plant systems ...
Azzarello, Elisa, Du, Yun-Long, Dubrovsky, Joseph G, Filichkin, Sergei, Friml, Jiri, Geisler, Markus, Ivanchenko, Maria G, Mancuso, Stefano, Medvecka, Eva, Megraw, Molly, Wang, Bangjun, Zhu, Jinsheng   +11 more
core   +2 more sources

Modeling the vacuolar storage of malate shed lights on pre- and post-harvest fruit acidity [PDF]

, 2014
Background: Malate is one of the most important organic acids in many fruits and its concentration plays a critical role in organoleptic properties. Several studies suggest that malate accumulation in fruit cells is controlled at the level of vacuolar ...
A De Angeli, A Etienne, A Etienne, A Etienne, A Gałecki, A Moing, AF Zuur, Audrey Etienne, BH Wu, BH Wu, C Bugaud, C Bugaud, C Bugaud, C Etienne, C Kettner, Christophe Bugaud, D Tieman, DP Briskin, F Harker, FA Smith, FX Chen, GB Seymour, H Monod, HP Rufner, I Walinga, J Berüter, JK Roberts, JM Davies, JM Davies, K Kobayashi, L Genevois, L Taiz, M Buttrose, M Esti, M Léchaudel, M Maeshima, M Souty, M Zambrano-Bigiarini, Michel Génard, ML Müller, N Terrier, N Terrier, P John, P Kovermann, P Lobit, P Martin-Prével, PA Rea, Philippe Lobit, PW Goodenough, R Ratajczak, S Meyer, V Emmerlich, WM Kliewer, Y Suzuki, YX Yao, ZW Dai   +55 more
core   +3 more sources