Results 81 to 90 of about 2,889 (188)

Melatonin protects aged oocytes from depalmitoylation-mediated quality reduction by promoting PPT1 degradation and antioxidation

Redox Biology
Oocyte aging is closely related to a decline in female fertility, accompanied by increased reactive oxygen species levels and changes in protein posttranslational modifications.
Rujun Ma, Mengqi Xue, Feiyan Ge, Kadiliya Jueraitetibaike, Shanmeizi Zhao, Zhang Qian, Zhaowanyue He, Hong Zhang, Ting Tang, Chun Cao, Chuwei Li, Lu Zheng, Tongmin Xue, Jie Dong, Jun Jing, Jian Zhong, Jinzhao Ma, Yang Yang, Yadong Huang, Xie Ge, Bing Yao, Li Chen   +21 more
doaj   +1 more source

Binding of hydroxychloroquine and chloroquine dimers to palmitoyl-protein thioesterase 1 (PPT1) and its glycosylated forms: a computational approach.

, 2021
International audienceThe lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) removes thioester-linked fatty acid groups from membrane-bound proteins to facilitate their proteolysis.
Vergoten, Gerard, Bailly, Christian
core   +1 more source

Cross-species efficacy of enzyme replacement therapy for CLN1 disease in mice and sheep

The Journal of Clinical Investigation, 2022
CLN1 disease, also called infantile neuronal ceroid lipofuscinosis (NCL) or infantile Batten disease, is a fatal neurodegenerative lysosomal storage disorder resulting from mutations in the CLN1 gene encoding the soluble lysosomal enzyme palmitoyl ...
Hemanth R. Nelvagal, Samantha L. Eaton, Sophie H. Wang, Elizabeth M. Eultgen, Keigo Takahashi, Steven Q. Le, Rachel Nesbitt, Joshua T. Dearborn, Nicholas Siano, Ana C. Puhl, Patricia I. Dickson, Gerard Thompson, Fraser Murdoch, Paul M. Brennan, Mark Gray, Stephen N. Greenhalgh, Peter Tennant, Rachael Gregson, Eddie Clutton, James Nixon, Chris Proudfoot, Stefano Guido, Simon G. Lillico, C. Bruce A. Whitelaw, Jui-Yun Lu, Sandra L. Hofmann, Sean Ekins, Mark S. Sands, Thomas M. Wishart, Jonathan D. Cooper   +29 more
doaj   +1 more source

Posidonia oceanica Leaves as a Natural Filler for Poly(Butylene Succinate‐Co‐Adipate) Composites: Characterization and Biodegradation Assessment in Seawater

Journal of Vinyl and Additive Technology, Volume 32, Issue 4, Page 988-1005, July 2026.
This study shows that incorporating 5–10 wt.% Posidonia oceanica , with or without micro‐talc, in PBSA preserves thermal stability, modifying crystallization behavior, and maintains good filler dispersion and interfacial adhesion. Mechanical properties are moderately stiffened. ABSTRACT This study investigates the use of Posidonia oceanica (PO) leaves,
Chiara Pedrotti, Damiano Rossi, Giovanni Raimondi, Riccardo Gallorini, Miriam Cappello, Irene Anguillesi, Marco Sandroni, Patrizia Cinelli, Maurizia Seggiani   +8 more
wiley   +1 more source

From Gene to Behavior: Investigation of Ppt1 and Ppt2 RNAi induced knock-down during Drosophila neurogenesis [PDF]

, 2011
Infantile Neuronal Ceroid Lipofuscinosis (INCL) is caused by a mutation of the gene CLN1, which encodes palmitoyl protein thioesterase 1 (PPT1). PPT1 is a lysosomal enzyme that cleaves the thioester bond connecting long chain fatty acids of palmitoylated
O\u27Hern, Patrick J.
core  

Thioesterase PPT1 balances viral resistance and efficient T cell crosspriming in dendritic cells [PDF]

Journal of Experimental Medicine, 2019
Conventional type 1 dendritic cells (cDC1s) are inherently resistant to many viruses but, paradoxically, possess fewer acidic phagosomes that enable antigen retention and cross-presentation. We report that palmitoyl-protein thioesterase 1 (PPT1), which catabolizes lipid-modified proteins in neurons, is highly expressed in cDC1s.
Pengju Ou, Lifen Wen, Xiaoli Liu, Jiancheng Huang, Xiaoling Huang, Chaofei Su, Ling Wang, Hai Ni, Boris Reizis, Cliff Y. Yang   +9 more
openaire   +2 more sources

Virulence, Host-Selective Toxin Production, and Development of Three Cochliobolus Phytopathogens Lacking the Sfp-Type 4′-Phosphopantetheinyl Transferase Ppt1

Molecular Plant-Microbe Interactions, 2015
The Sfp-type 4′-phosphopantetheinyl transferase Ppt1 is required for activation of nonribosomal peptide synthetases, including α-aminoadipate reductase (AAR) for lysine biosynthesis and polyketide synthases, enzymes that biosynthesize peptide and ...
Nur Ain Izzati Mohd Zainudin, Bradford Condon, Lieselotte De Bruyne, Christof Van Poucke, Qing Bi, Wei Li, Monica Höfte, B. Gillian Turgeon   +7 more
doaj   +1 more source

Scientific opinion on animal exposure to zearalenone in feed materials and compound feed in the Republic of Croatia

Food Risk Assess Europe, Volume 4, Issue 3, July 2026.
ABSTRACT The Croatian Agency for Agriculture and Food (HAPIH), through the work of the Centre for Food Safety in preparing scientific opinions on risks in food and feed, provides scientific and technical support to the authorities responsible for food and feed safety in making informed risk‐management decisions.
Brigita Hengl, Jasenka Petrić, Matija Domaćinović, Zlatko Janječić, Jelka Pleadin, Andreja Prevendar Crnić, Nataša Pintić Pukec, Andreja Babić   +7 more
wiley   +1 more source

Homozygous PPT1 Splice Donor Mutation in a Cane Corso Dog With Neuronal Ceroid Lipofuscinosis [PDF]

Journal of Veterinary Internal Medicine, 2017
Abstract A 10-month-old spayed female Cane Corso dog was evaluated after a 2-month history of progressive blindness, ataxia, and lethargy. Neurologic examination abnormalities indicated a multifocal lesion with primarily cerebral and cerebellar signs. Clinical worsening resulted in humane euthanasia.
Kolicheski, A., Barnes Heller, H.L., Arnold, S., Schnabel, R.D., Taylor, J.F., Knox, C.A., Mhlanga‐Mutangadura, T., O'Brien, D.P., Johnson, G.S., Dreyfus, J., Katz, M.L.   +10 more
openaire   +2 more sources

Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis

Neurobiology of Disease, 2007
Infantile neuronal ceroid lipofuscinosis (INCL) is caused by deficiency of the lysosomal enzyme, palmitoyl protein thioesterase 1 (PPT1). We have investigated the onset and progression of pathological changes in Ppt1 deficient mice (Ppt1−/−) and the ...
Catherine Kielar, Lucy Maddox, Ellen Bible, Charlie C. Pontikis, Shannon L. Macauley, Megan A. Griffey, Michael Wong, Mark S. Sands, Jonathan D. Cooper   +8 more
doaj   +1 more source