Results 71 to 80 of about 2,889 (188)

Formerly palmitoylated peptides identified for putative PPT1 substrates.

, 2022
[x] Carbamidomethyl indicates location of palmitoylated cysteine (C) in peptide sequence. PPT1, palmitoyl protein thioesterase 1. (PDF)
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

THE ROLE OF PPT1 DURING EMBRYONIC NEURAL DEVELOPMENT IN DROSOPHILA MELANOGASTER

The FASEB Journal, 2008
Palmitoyl‐protein thioesterase 1 (PPT1) is a lysosomal enzymatic protein which acts in the depalmitoylation of cysteine modified proteins. Mutations in PPT1 results in the pediatric neurological disease called Infantile Ceroid Lipofuscinosis (INCL).
Cassandra Denefrio, Quynh Chu‐LaGraff
openaire   +1 more source

PPT1 C6S exhibits elevated enzymatic activity in the cell lysates (A) and the cell media (C).

, 2016
The activity of PPT1 in COS7 cells was monitored following the overexpression of either PPT1 or PPT1 C6S, or with the addition of either HA-DHHC3 or HA-DHHC3 dominant negative mutant.
Orly Reiner (20376), Tamar Sapir (20381), Michal Segal-Salto (843030)   +2 more
core   +1 more source

Rare‐Variant Burden across Lysosomal Genes Implicates Sialylation and Ganglioside Metabolism in Parkinson's Disease

Movement Disorders, Volume 41, Issue 9, Page 2349-2356, September 2026.
Abstract Background Lysosomal dysfunction is central to Parkinson's disease (PD) pathogenesis, with GBA1 representing the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid, and ceramide metabolism have been proposed as contributors to PD, highlighting the need for genetic analyses ...
Konstantin Senkevich, Sitki Cem Parlar, Cloe Chantereault, Lang Liu, Eric Yu, Uladzislau Rudakou, Jamil Ahmad, Jennifer A. Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupré, Lior Greenbaum, Sharon Hassin‐Baer, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Roy N. Alcalay, Ziv Gan‐Or   +21 more
wiley   +1 more source

WT and PPT1 KO synaptic protein expression.

, 2022
Average KO/WT protein expression ratios for data shown in Fig 2D. p-Values were calculated using a 2-tailed t test. Blue denotes decreases (1.5 fold), while black denotes unchanged expression.
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice [PDF]

Proceedings of the National Academy of Sciences, 2001
PPT1 and PPT2 encode two lysosomal thioesterases that catalyze the hydrolysis of long chain fatty acyl CoAs. In addition to this function, PPT1 (palmitoyl-protein thioesterase 1) hydrolyzes fatty acids from modified cysteine residues in proteins that are undergoing ...
P, Gupta, A A, Soyombo, A, Atashband, K E, Wisniewski, J M, Shelton, J A, Richardson, R E, Hammer, S L, Hofmann   +7 more
openaire   +2 more sources

Novel Behavioral Markers in the Ppt1-/- Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis [PDF]

, 2013
Infantile neuronal ceroid lipofuscinosis (INCL) is a lysosomal storage disease that is debilitating and fatal to children before their teenage years. The palmitoyl protein thioesterase 1 (PPT1) knockout (Ppt1-/-) mouse is an appropriate animal model that
Dearborn, Joshua Thomas
core   +1 more source

Novel interactions of CLN5 support molecular networking between Neuronal Ceroid Lipofuscinosis proteins

BMC Cell Biology, 2009
Background Neuronal ceroid lipofuscinoses (NCLs) comprise at least eight genetically characterized neurodegenerative disorders of childhood. Despite of genetic heterogeneity, the high similarity of clinical symptoms and pathology of different NCL ...
Jalanko Anu, Sipilä Tessa, Schmiedt Mia-Lisa, Heine Claudia, von Schantz Carina, Lyly Annina, Kyttälä Aija   +6 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source