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Michaelis-Menten graph of PPT1 and PPT1 C6S.
, 2016 The Km and Vmax of PPT1 and PPT1 C6S were calculated using the Michaelis-Menten equation following plotting the results of enzymatic activity obtained with different concentrations of the substrate (N = 9) A) Michaelis-Menten graph derived from the cell ...
Orly Reiner (20376) +2 more
core +1 more source
Endocytic PPT1 substrates contain the DHHC17 recognition motif.
, 2022 (A) Alignment of DHHC17 recognition motif for 9 endocytic PPT1 substrates with 26 amino acids on either side. The motif is noted above the logo plot. There are no other motifs surrounding the DHHC17 motif.
Sreeganga S. Chandra (12329746) +8 more
core +1 more source
The Interactome of Palmitoyl-Protein Thioesterase 1 (PPT1) Affects Neuronal Morphology and Function [PDF]
, 2022 Palmitoyl-protein thioesterase 1 (PPT1) is a depalmitoylation enzyme that is mutated in cases of neuronal ceroid lipofuscinosis (NCL). The hallmarks of the disease include progressive neurodegeneration and blindness, as well as seizures.
Hansson KM +5 more
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Plus-strand DNA Synthesis of the Yeast Retrotransposon Ty1 is Initiated at Two Sites, PPT1 Next to the 3′ LTR and PPT2 Within thepolGene. PPT1 is Sufficient for Ty1 Transposition [PDF]
Journal of Molecular Biology, 1995 Long terminal repeat elements and retroviruses require primers for initiation of minus and plus-strand DNA synthesis by reverse transcriptase. Here we demonstrate genetically that plus-strand DNA synthesis of the yeast Ty1 element is initiated at two sites located at the 5' boundary of the 3' long terminal repeat (PPT1) and near the middle of the pol ...
Heyman, T. +4 more
openaire +3 more sources
Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme
Molecular Genetics and Metabolism Reports, 2022 Neuronal ceroid lipofuscinosis type 1(CLN1 disease) is a rare autosomal recessive lysosomal storage disease caused by genetic defects of palmitoyl protein thioesterase-1(PPT1), leading to accumulation of lipofuscin granules in brain and progressive ...
Andreas Hahn +7 more
doaj +1 more source
PPT1 is palmitoylated by DHHC3 and DHHC7.
, 2016 A) PPT1 was co-transfected with HA tagged DHHC enzymes to HEK293 cells. The cells were metabolically labeled with 17-ODYA and PPT1 was immunoprecipitated with anti-PPT1 antibodies.
Orly Reiner (20376) +2 more
core +1 more source
, 2016 Even though protein phosphatases are key regulators of signal transduction, their cellular mechanisms of action are poorly understood. Here, we undertook a large-scale proteomics survey to identify cellular protein targets of a serine/threonine ...
Johannes Buchner (277160) +5 more
core +2 more sources
Frontiers in Oncology, 2023 IntroductionTumor purity takes on critical significance to the progression of solid tumors. The aim of this study was at exploring potential prognostic genes correlated with tumor purity in hepatocellular carcinoma (HCC) by bioinformatics analysis ...
Yan Zhao +5 more
doaj +1 more source
PPT1 is expressed and enzymatically active in synaptic cytosolic subcompartments in neurons.
, 2022 (A) hPPT1 (green) colocalizes with synaptophysin 1 (SYPH; red) in MAP2+ neurites in WT mouse primary neuronal culture (50 μm scale bars; 10 μm scale bar in higher magnification image).
Sreeganga S. Chandra (12329746) +8 more
core +1 more source
Production of lysophosphatidylcholine by cPLA2 in the brain of mice lacking PPT1 is a signal for phagocyte infiltration [PDF]
Human Molecular Genetics, 2007 In the majority of neurodegenerative storage disorders, neuronal death in the brain is followed by infiltration of phagocytic cells (e.g. activated microglia, astroglia and macrophages) for the efficient removal of cell corpses. However, it is increasingly evident that these phagocytes may also cause death of adjoining viable neurons contributing to ...
Zhongjian, Zhang +11 more
openaire +2 more sources