Results 31 to 40 of about 2,889 (188)

Identification of PPT1 as a lysosomal core gene with prognostic value in hepatocellular carcinoma

Bioscience Reports, 2023
Abstract Hepatocellular carcinoma (HCC) is the most frequent cancer worldwide with a poor prognosis. Unfortunately, there are few reports on effective biomarkers for HCC, identification of novel cancer targets is urgently needed. Lysosomes are central organelles for degradation and recycling processes in cells, and how lysosome-related ...
Wei Tian, Chenyu Li, Jiaqi Ren, Pengfei Li, Jingyuan Zhao, Shuai Li, Deshi Dong   +6 more
openaire   +2 more sources

PPT1-mediated depalmitoylation facilitates disulfide bond formation.

, 2022
(A) Schematic of modified Acyl RAC. (i) Free thiols were blocked with NEM prior to reduction of disulfide bonds with TCEP. (ii) Free thiols generated by TCEP treatment were modified with heavy-labeled NEM (dNEM). iii.
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

BATTEN DISEASE CAUSED BY A NOVEL MUTATION IN THE PPT1 GENE [PDF]

RETINAL Cases & Brief Reports, 2016
To report a case of Batten disease due to a previously unreported mutation in PPT1.A 9-year-old girl presented with classic clinical findings of Batten Disease.Genetic testing for the mutations in the most common Batten disease gene, CLN3, was negative.
Tatyana I, Metelitsina, Darrel J, Waggoner, Michael A, Grassi   +2 more
openaire   +2 more sources

What Matters for C4 Transporters: Evolutionary Changes of Phosphoenolpyruvate Transporter for C4 Photosynthesis

Frontiers in Plant Science, 2020
C4 photosynthesis is a complex trait that evolved from its ancestral C3 photosynthesis by recruiting pre-existing genes. These co-opted genes were changed in many aspects compared to their counterparts in C3 species.
Ming-Ju Amy Lyu, Yaling Wang, Jianjun Jiang, Xinyu Liu, Genyun Chen, Xin-Guang Zhu   +5 more
doaj   +1 more source

PPT1 selectively depalmitoylates GAP43 to regulate neuronal excitability and cognitive function. [PDF]

Sci Adv
Palmitoylation is a reversible lipid modification, regulating protein localization and signaling in neurons. Growth-associated protein 43 (GAP43) requires palmitoylation for axonal development and synaptic plasticity; however, its depalmitoylase and regulation in neural circuits remain unknown.
Tong J, Liu Y, Wu W, Wang Q, Yang H, Li J, Gao Z, Liu W, Liu J, Chazot P, Lu L, Liang Y, Lu C.   +12 more
europepmc   +2 more sources

Medium-confidence validated PPT1 substrates.

, 2022
Medium-confidence validated PPT1 substrates.
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast

Frontiers in Physiology, 2020
Skeletal muscle differentiation is an essential process for the maintenance of muscle development and homeostasis. Reactive oxygen species (ROS) are critical signaling molecules involved in muscle differentiation. Palmitoyl protein thioesterase 1 (PPT1),
Hyeong Rok Yun, Hyeong Rok Yun, Yong Hwa Jo, Yong Hwa Jo, Jieun Kim, Jieun Kim, Ngoc Ngo Yen Nguyen, Ngoc Ngo Yen Nguyen, Yoonhwa Shin, Yoonhwa Shin, Sung Soo Kim, Sung Soo Kim, Tae Gyu Choi, Tae Gyu Choi   +13 more
doaj   +1 more source

Residual PPT1 substrates.

, 2022
Proteins identified in the secondary validation screen that were not identified as putative substrates in the primary screen. PPT1, palmitoyl protein thioesterase 1. (PDF)
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

High-confidence validated PPT1 substrates.

, 2022
High-confidence validated PPT1 substrates.
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

The Batten disease Palmitoyl Protein Thioesterase 1 gene regulates neural specification and axon connectivity during Drosophila embryonic development. [PDF]

PLoS ONE, 2010
Palmitoyl Protein Thioesterase 1 (PPT1) is an essential lysosomal protein in the mammalian nervous system whereby defects result in a fatal pediatric disease called Infantile Neuronal Ceroids Lipofuscinosis (INCL).
Quynh Chu-LaGraff, Cassandra Blanchette, Patrick O'Hern, Cassandra Denefrio   +3 more
doaj   +1 more source