Results 11 to 20 of about 2,889 (188)

Quantitative analysis of PPT1 interactome in human neuroblastoma cells [PDF]

Data in Brief, 2015
Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid chains such as palmitate from modified cysteine residues of proteins. The data shown here result
Enzo Scifo, Agnieszka Szwajda, Rabah Soliymani, Francesco Pezzini, Marzia Bianchi, Arvydas Dapkunas, Janusz Dębski, Kristiina Uusi-Rauva, Michał Dadlez, Anne-Claude Gingras, Jaana Tyynelä, Alessandro Simonati, Anu Jalanko, Marc H. Baumann, Maciej Lalowski   +14 more
doaj   +7 more sources

Intratumoral PPT1-positive macrophages determine immunosuppressive contexture and immunotherapy response in hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer, 2023
Background Hepatocellular carcinoma (HCC) is a malignancy with limited treatment options and poor prognosis. Macrophages are enriched in the HCC microenvironment and have a significant impact on disease progression and therapy efficacy.
Qiang Zhou, Dongmei Gao, Wenxin Xu, Yong Yi, Yi Shi, Qiongzhu Dong, Ning Ren, Chenhao Zhou, Jialei Weng, Shaoqing Liu, Minghao Xu, Yinghao Shen   +11 more
doaj   +4 more sources

An over-expression system for characterizing Ppt1 function in Drosophila [PDF]

BMC Neuroscience, 2003
Background The infantile onset form of Neuronal Ceroid Lipofuscinoses (INCL) is the earliest and most severe form of NCL, with neurological symptoms that reflect massive neurodegeneration in the CNS and retina.
Korey Christopher A, MacDonald Marcy E
doaj   +4 more sources

PPT1 inhibition enhances the antitumor activity of anti–PD-1 antibody in melanoma [PDF]

JCI Insight, 2020
New strategies are needed to enhance the efficacy of anti–programmed cell death protein antibody (anti–PD-1 Ab) in cancer. Here, we report that inhibiting palmitoyl-protein thioesterase 1 (PPT1), a target of chloroquine derivatives like ...
Gaurav Sharma, Rani Ojha, Estela Noguera-Ortega, Vito W. Rebecca, John Attanasio, Shujing Liu, Shengfu Piao, Jennifer J. Lee, Michael C. Nicastri, Sandra L. Harper, Amruta Ronghe, Vaibhav Jain, Jeffrey D. Winkler, David W. Speicher, Jerome Mastio, Phyllis A. Gimotty, Xiaowei Xu, E. John Wherry, Dmitry I. Gabrilovich, Ravi K. Amaravadi   +19 more
doaj   +5 more sources

Reversible Cysteine Acylation Regulates the Activity of Human Palmitoyl-Protein Thioesterase 1 (PPT1). [PDF]

PLoS ONE, 2016
Mutations in the depalmitoylating enzyme gene, PPT1, cause the infantile form of Neuronal Ceroid Lipofuscinosis (NCL), an early onset neurodegenerative disease.
Michal Segal-Salto, Tamar Sapir, Orly Reiner   +2 more
doaj   +5 more sources

Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells [PDF]

Molecular and Cellular Oncology, 2018
DQ661 is a novel dimeric quinacrine that affects multiple lysosomal functions (autophagy and macropinocytosis) and mTORC1 (mechanistic target of rapamycin) activity by specifically targeting protein-palmitoyl thioesterase 1 (PPT1).
Ravi Amaravadi, Michael Nicastri
exaly   +4 more sources

High PPT1 expression predicts poor clinical outcome and PPT1 inhibitor DC661 enhances sorafenib sensitivity in hepatocellular carcinoma [PDF]

Cancer Cell International, 2022
Background Adaptive resistance and side effects of sorafenib treatment result in unsatisfied survival of patients with hepatocellular carcinoma (HCC).
Jianjun Xu, Zhe Su, Xiang Cheng, Shaobo Hu, Wenjie Wang, Tianhao Zou, Xing Zhou, Zifang Song, Yun Xia, Yang Gao, Qichang Zheng   +10 more
doaj   +3 more sources

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons

BMC Cell Biology, 2007
Background Neuronal ceroid lipofuscinoses (NCLs) are collectively the most common type of recessively inherited childhood encephalopathies. The most severe form of NCL, infantile neuronal ceroid lipofuscinosis (INCL), is caused by mutations in the CLN1 ...
Jauhiainen Matti, Saarela Jani, Kopra Outi, Salonen Tarja, von Schantz Carina, Lyly Annina, Kyttälä Aija, Jalanko Anu   +7 more
doaj   +2 more sources

PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer [PDF]

Cancer Discovery, 2019
Clinical trials repurposing lysosomotropic chloroquine (CQ) derivatives as autophagy inhibitors in cancer demonstrate encouraging results, but the underlying mechanism of action remains unknown.
Goldman, Aaron R., Chude, Cynthia I., Winkler, Jeffrey D., Ronghe, Amruta, Ojha, Rani, Noguera-Ortega, Estela, Alicea, Gretchen M., Fennelly, Colin, Zhang, Gao, Lee, Jennifer J., Martorella, Alessandra, Piao, Shengfu, Speicher, David W., McAfee, Quentin, Marmorstein, Ronen, Schuchter, Lynn M., Amaravadi, Ravi K., Gimotty, Phyllis A., Barber-Rotenberg, Julie S., Rebecca, Vito W., Xu, Xiaowei, Nicastri, Michael C., McLaughlin, Noel P., Herlyn, Meenhard   +23 more
core   +3 more sources

GABAAR-PPT1 palmitoylation homeostasis controls synaptic transmission and circuitry oscillation

Translational Psychiatry
The infantile neuronal ceroid lipofuscinosis, also called CLN1 disease, is a fatal neurodegenerative disease caused by mutations in the CLN1 gene encoding palmitoyl protein thioesterase 1 (PPT1).
Jia Tong, Jingjing Gao, Yawei Qi, Ziyan Gao, Qianqian Wang, Yang Liu, Tiangang Yuan, Minglong Ren, Guixia Yang, Zhaoyue Li, Jin Li, Hongyuan Sun, Xing Zhao, Yeung-Yeung Leung, Yonghui Mu, Jiamin Xu, Chengbiao Lu, Shiyong Peng, Lihao Ge   +18 more
doaj   +3 more sources