Results 101 to 110 of about 2,889 (188)

Understanding the dynamic nature of plant lipid anabolic and catabolic metabolism is key to sustainable oilseed engineering

New Phytologist, Volume 249, Issue 5, Page 2196-2214, March 2026.
Summary Plant‐derived oils are essential sources of reduced carbon and various fatty acid (FA) structures for food, biofuels, and the oleochemical industry. Despite extensive efforts, engineering mainstream oilseed crops to produce high levels of industrially valuable unusual FAs (UFAs) remains challenging.
Prasad Parchuri, Sean T. McGuire, Matthew G. Garneau, Niña Alyssa M. Barroga, Philip D. Bates   +4 more
wiley   +1 more source

Cln3‐mutations underlying juvenile neuronal ceroid lipofuscinosis cause significantly reduced levels of Palmitoyl‐protein thioesterases‐1 (Ppt1)‐protein and Ppt1‐enzyme activity in the lysosome

Journal of Inherited Metabolic Disease, 2019
AbstractMutations in at least 13 different genes (called CLNs) underlie various forms of neuronal ceroid lipofuscinoses (NCLs), a group of the most common neurodegenerative lysosomal storage diseases. While inactivating mutations in the CLN1 gene, encoding palmitoyl‐protein thioesterases‐1 (PPT1), cause infantile NCL (INCL), those in the CLN3 gene ...
Abhilash P. Appu, Maria B. Bagh, Tamal Sadhukhan, Avisek Mondal, Sydney Casey, Anil B. Mukherjee   +5 more
openaire   +3 more sources

Adenovirus-mediated PPT1 was expressed in mouse fibroblasts and neurons

, 2011
Copyright information:Taken from "Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons"http://www.biomedcentral.com/1471-2121/8/22BMC Cell Biology 2007;8():22-22.Published online
Carina von Schantz (45483), Anu Jalanko (45488), Outi Kopra (7927), Tarja Salonen (71261), Jani Saarela (50412), Matti Jauhiainen (71262), Annina Lyly (71260), Aija Kyttälä (71263)   +7 more
core   +1 more source

Cyclical palmitoylation regulates TLR9 signalling and systemic autoimmunity in mice

Nature Communications
Toll-like receptor 9 (TLR9) recognizes self-DNA and plays intricate roles in systemic lupus erythematosus (SLE). However, the molecular mechanism regulating the endosomal TLR9 response is incompletely understood.
Hai Ni, Yinuo Wang, Kai Yao, Ling Wang, Jiancheng Huang, Yongfang Xiao, Hongyao Chen, Bo Liu, Cliff Y. Yang, Jijun Zhao   +9 more
doaj   +1 more source

Depalmitoylation by Palmitoyl-Protein Thioesterase 1 in Neuronal Health and Degeneration

Frontiers in Synaptic Neuroscience, 2019
Protein palmitoylation is the post-translational, reversible addition of a 16-carbon fatty acid, palmitate, to proteins. Protein palmitoylation has recently garnered much attention, as it robustly modifies the localization and function of canonical ...
Kevin P. Koster, Akira Yoshii, Akira Yoshii, Akira Yoshii   +3 more
doaj   +1 more source

CRISPR/Cas9 mediated generation of an ovine model for infantile neuronal ceroid lipofuscinosis (CLN1 disease)

Scientific Reports, 2019
The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating monogenetic lysosomal disorders that affect children and young adults with no cure or effective treatment currently available.
S. L. Eaton, C. Proudfoot, S. G. Lillico, P. Skehel, R. A. Kline, K. Hamer, N. M. Rzechorzek, E. Clutton, R. Gregson, T. King, C. A. O’Neill, J. D. Cooper, G. Thompson, C. B. Whitelaw, T. M. Wishart   +14 more
doaj   +1 more source

Generation of WT and PPT1 KO palmitome and proteome expands the repertoire of known palmitoylated proteins in the brain.

, 2022
(A) Venn diagram of 3 independent palmitome experiments exhibits 1,795 common proteins. (B) Volcano plot of fold change between genotypes (PPT1 KO/WT) for common proteins with putative synaptic PPT1 substrates in blue (Fig 2B, S2 Table, S1 Data). A total
Sreeganga S. Chandra (12329746), Vicky Chou (12329740), Helen R. Zhao (12329737), Sofia Massaro Tieze (12329731), TuKiet T. Lam (610361), Betül Yücel (12329734), Gregory S. Wirak (12329743), Susumu Tomita (6956876), Erica L. Gorenberg (12329728)   +8 more
core   +1 more source

Mice deficient in the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1) display a complex retinal phenotype

Scientific Reports, 2019
Neuronal ceroid lipofuscinosis (NCL) type 1 (CLN1) is a neurodegenerative storage disorder caused by mutations in the gene encoding the lysosomal enzyme palmitoyl-protein thioesterase 1 (PPT1).
Yevgeniya Atiskova, Susanne Bartsch, Tatyana Danyukova, Elke Becker, Christian Hagel, Stephan Storch, Udo Bartsch   +6 more
doaj   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Lysosomal metabolism of lipid-modified proteins

Journal of Lipid Research, 2006
Much is now understood concerning the synthesis of prenylated and palmitoylated proteins, but what is known of their metabolic fate? This review details metabolic pathways for the lysosomal degradation of S-fatty acylated and prenylated proteins. Central
Jui-Yun Lu, Sandra L. Hofmann
doaj   +1 more source

Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons-6

, 2011
Copyright information:Taken from "Glycosylation, transport, and complex formation of palmitoyl protein thioesterase 1 (PPT1) – distinct characteristics in neurons"http://www.biomedcentral.com/1471-2121/8/22BMC Cell Biology 2007;8():22-22.Published online
Carina von Schantz (45483), Anu Jalanko (45488), Outi Kopra (7927), Tarja Salonen (71261), Jani Saarela (50412), Matti Jauhiainen (71262), Annina Lyly (71260), Aija Kyttälä (71263)   +7 more
core   +1 more source