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Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits [PDF]

Current Research in Food Science
Pyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as
Tingdong Yan, Muhammad Farrukh Nisar, Xiaomeng Hu, Jieming Chang, Yichen Wang, Yan Wu, Zhaoguo Liu, Yi Cai, Jia Jia, Yanming Xiao, Chunpeng Wan   +10 more
doaj   +5 more sources

The Natural Redox Cofactor Pyrroloquinoline Quinone (PQQ) Enables Photocatalytic Radical Cyclizations. [PDF]

Angew Chem Int Ed Engl
Photoenzymatic catalysis facilitates stereoselective new‐to‐nature chemistry under mild conditions. In addition to the rational design of artificial photoenzymes, naturally occurring redox enzymes can be repurposed to promote photoredox catalysis in the ...
Bahukhandi SB, Klein AS, Mustafa G, Weyh M, Walter A, Thyrhaug E, Hauer J, Storch G, Zeymer C.   +8 more
europepmc   +2 more sources

Pre-conditioning with PQQ during pregnancy alleviates LPS-induced placental damage and improves the fetal survival and growth in mice [PDF]

Frontiers in Endocrinology
BackgroundIntrauterine infection is a major cause of preterm birth, fetal demise, and growth restriction. Placental damage resulting from such infections plays a central role in mediating these adverse outcomes.
Yongli Han, Yan Zhu, Xiaohui Lu, Tingting Fan, Yina Yin, Pengfei Liu, Xiuliang Dai, Hongbin Xu   +7 more
doaj   +2 more sources

Effects of Pyrroloquinoline Quinone (PQQ) on Ischemia-Reperfusion Injury in Rat Ovaries: Histological and Biochemical Assessments [PDF]

Bulletin of Emergency and Trauma, 2019
Objective: To evaluate effects of pyrroloquinoline quinone (PQQ) on ischemia-reperfusion injury using a rat ovary model.Method: Thirty healthy female Wistar rats with 250g were randomized into five experimental groups (n = 6): Group SHAM: The rats ...
Pegah Parhizkar, Rahim Mohammadi, Rasoul Shahrouz, Vahid Mohammadi   +3 more
doaj   +2 more sources

Deciphering the assembly process of PQQ dependent methanol dehydrogenase [PDF]

Nature Communications
Pyrroloquinoline quinone (PQQ)-dependent methanol dehydrogenases (MDHs), the periplasmic metalloenzymes in Gram-negative methylotrophic bacteria, play a pivotal role in methane and methanol bio-utilization.
Haichuan Zhou, Junqing Sun, Jian Cheng, Min Wu, Jie Bai, Qian Li, Jie Shen, Manman Han, Chen Yang, Liangpo Li, Yuwan Liu, Qichen Cao, Weidong Liu, Haixia Xiao, Hongjun Dong, Feng Gao, Huifeng Jiang   +16 more
doaj   +2 more sources

High-affinity PQQ import is widespread in Gram-negative bacteria. [PDF]

Sci Adv
PQQ is a soluble redox cofactor used by diverse bacteria to oxidise fuel compounds as a source of electrons for the respiratory chain. Many Gram-negative bacteria that encode PQQ-dependent enzymes do not possess the biosynthetic machinery for its ...
Munder F, Voutsinos M, Hantke K, Venugopal H, Grinter R.   +4 more
europepmc   +2 more sources

Pyrroloquinoline quinone targets senescent osteoclasts and reduces spinal pain and endplate degeneration in a lumbar spine instability mouse model [PDF]

Journal of Translational Medicine
Background Pyrroloquinoline Quinone (PQQ) is a redox cofactor with potent antioxidant and anti-inflammatory properties. This study investigated the therapeutic potential of PQQ in alleviating spinal pain and degeneration in a lumbar spine instability ...
Qinghe Geng, Yan Geng, Ke Heng, Juan Zhai, Xingchen Song, Liangwei Sha, Yinuo Geng, Peiru Nie, Fanshuo Liu, Huaiyuan Zhai, Junli Huang, Yanhong Liu, Mei Li, Guoqiang Wang, Rui Geng, Kui Xue, Qilong Wang, Wanying Huang, Shuangshuang Suo, Huanyu Zhang, Ying Geng, Yuanji Yang, Junyun Lan, Hengsheng Hu, Shengnan Liu, Xiangfei Meng, Yilong Guo, Jie Li   +27 more
doaj   +2 more sources

Enhanced bacterial cellulose production in Komagataeibacter sucrofermentans: impact of different PQQ-dependent dehydrogenase knockouts and ethanol supplementation

Biotechnology for Biofuels and Bioproducts
Background Bacterial cellulose (BC) is a biocompatible material with unique mechanical properties, thus holding a significant industrial potential.
Pedro Montenegro-Silva, Tom Ellis, Fernando Dourado, Miguel Gama, Lucília Domingues   +4 more
doaj   +2 more sources

Pyrroloquinoline Quinone Mitigates Testicular Injury and Reduces Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Rats with Testicular Ischemia–Reperfusion Injury [PDF]

Antioxidants
Testicular torsion–detorsion (T/D) induces ischemia–reperfusion injury, leading to mitochondrial dysfunction, oxidative stress, apoptosis, and spermatogenic impairment.
Syuan-Hao Syu, Chao-Yuan Chang, Hung-Jen Shih, Chun-Jen Huang   +3 more
doaj   +2 more sources

Triple-Model Immunoassays with the Self-Assemblies of Three-in-One Small Molecules as Signaling Labels [PDF]

Biosensors
Multiple-mode immunoassays have the advantages of self-correction, self-validation, and high accuracy and reliability. In this work, we developed a strategy for the design of triple-mode immunoassays with the self-assemblies of three-in-one small ...
Zhaojiang Yu, Wenqi Yuan, Mingyi Qiao, Lin Liu   +3 more
doaj   +2 more sources