Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats. [PDF]
PLoS ONE, 2011 We have reported that pyrroloquinoline quinone (PQQ) improves reproduction, neonatal development, and mitochondrial function in animals by mechanisms that involve mitochondrial related cell signaling pathways.
Kathryn Bauerly +8 more
doaj +1 more source
Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellAs a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Jiang B +6 more
europepmc +2 more sources
Animal Nutrition, 2023 Hindered growth often occurs because of psychological and environmental stress during the weaning period of piglets. This study aimed to compare the effects of growth performance, diarrhea indices, digestibility of nutrients, antioxidant capacity ...
Chenyu Shi +6 more
doaj +1 more source
Journal of Developmental Origins of Health and Disease, 2023 Background: Intrauterine growth restriction (IUGR) exerts a negative impact on developing cardiomyocytes and emerging evidence suggests activation of oxidative stress pathways plays a key role in this altered development.
Jordan Mattern +5 more
semanticscholar +1 more source
Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary activity family in the database of carbohydrate-active enzymes. [PDF]
PLoS ONE, 2014 Pyrroloquinoline quinone (PQQ) is a redox cofactor utilized by a number of prokaryotic dehydrogenases. Not all prokaryotic organisms are capable of synthesizing PQQ, even though it plays important roles in the growth and development of many organisms ...
Hirotoshi Matsumura +9 more
doaj +1 more source
Pyrroloquinoline quinine inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos in mouse bone marrow cells and inhibits wear particle-induced osteolysis in mice. [PDF]
PLoS ONE, 2013 The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study.
Lingbo Kong +6 more
doaj +1 more source
PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice
Frontiers in Endocrinology, 2022 Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the ...
Xiuliang Dai +7 more
semanticscholar +1 more source
Pyrroloquinoline-quinone to reduce fat accumulation and ameliorate obesity progression
Frontiers in Molecular Biosciences, 2023 Obesity is a major health concern worldwide, and its prevalence continues to increase in several countries. Pyrroloquinoline quinone (PQQ) is naturally found in some foods and is available as a dietary supplement in its disodium crystal form.
Nur Syafiqah Mohamad Ishak +1 more
doaj +1 more source
Bioengineered, 2021 PQQ has anti-inflammatory and anti-oxidant effects. PQQ can relieve high glucose-induced renal cell damage by suppressing Keap1 expression. Keap1 can interact with CUL3. Upregulation of CUL3 facilitates the apoptosis of LPS-induced podocytes.
Yanhong Wu, Meiling Zhao, Zhaoheng Lin
semanticscholar +1 more source
Biomolecules, 2021 Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and ...
Karen R. Jonscher +2 more
doaj +1 more source