Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellAs a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Jiang B +6 more
europepmc +2 more sources
Novel essential role of ethanol oxidation genes at low temperature revealed by transcriptome analysis in the antarctic bacterium pseudomonas extremaustralis [PDF]
, 2015 Temperature is one of the most important factors for bacterial growth and development. Cold environments are widely distributed on earth, and psychrotolerant and psychrophilic microorganisms have developed different adaptation strategies to cope with the
Gómez Lozano, Maria +6 more
core +11 more sources
Determination of PQQ in quinoproteins with covalently bound cofactor and in PQQ‐derivatives [PDF]
FEBS Letters, 1989 Application of the so‐called hexanol extraction procedure for PQQ determination, originally based on detachment of the cofactor from quinoproteins and conversion into PQQ‐5,5‐dihexyl ketal, leads in several cases to a number of products due to uncontrollable esterification.
van der Meer, Robert A. +3 more
openaire +1 more source
PQQ-linked extracellular glucose oxidation and chemotaxis towards this cofactor in rhizobia [PDF]
FEMS Microbiology Letters, 1996 The presence of the pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase in several strains of different Rhizobium species and of Bradyrhizobium japonicum was investigated. It was found that most strains were only able to synthesize the apo-enzyme, whereas in three strains, Rhizobium meliloti 102F34 and Bradyrhizobium japonicum strains ...
Boiardi, J.L. +2 more
openaire +4 more sources
Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice
Scientific Reports, 2022 We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice.
Ying Gao +4 more
doaj +1 more source
Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. [PDF]
PLoS ONE, 2014 Therapeutic strategies designed to inhibit the activation of microglia may lead to significant advancement in the treatment of most neurodegenerative diseases.
Chongfei Yang +7 more
doaj +1 more source
Pyrroloquinoline quinone (PQQ) is the organic cofactor in soybean lipoxygenase‐1 [PDF]
FEBS Letters, 1988 Treatment of soybean lipoxygenase‐1 (SLO) with phenylhydrazine (PH) induced inactivation and a maximum (350 nm) in the absorption spectrum of the enzyme. To detach the product having this absorption maximum, proteolysis was required. The product appeared to be the C(5) phenylhydrazone of pyrroloquinoline quinone (PQQ).
van der Meer, Robert A. +1 more
openaire +1 more source
Acta Neuropathologica Communications, 2023 Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai +7 more
doaj +1 more source
Mediators of Inflammation, 2022 The current asthma therapies are inadequate for many patients with severe asthma. Pyrroloquinoline quinone (PQQ) is a naturally-occurring redox cofactor and nutrient that can exert a multitude of physiological effects, including anti-inflammatory and ...
Zhihui Min +5 more
doaj +1 more source
Bioelectrocatalytic activity of reconstituted peroxidase on hemin-terminated PQQ-modified electrodes
Sensors and Actuators Reports, 2022 Efficient direct electrical communication between an enzyme redox center and an electrode is of great interest from the viewpoints of application to reagentless biosensors and biofuel cells.
Kikuo Komori, Tomoki Aikawa
doaj +1 more source