Pyrroloquinoline Quinone Reprograms the Single-Cell Landscape of Immune Aging in Hematopoietic Immune System. [PDF]
Aging CellThis study demonstrates that aging induces oxidative stress and inflammation in the hematopoietic immune system, resulting in immune homeostasis dysfunction, including alterations in B cells and hematopoietic stem cells, senescent cells (SnCs) accumulation, and senescence‐associated secretory phenotypes (SASPs) production. Notably, the study highlights
Liu X +11 more
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Growth and gene expression of Pseudomonas nitroreducens TX1 on octylphenol polyethoxylate surfactants [PDF]
Applied Microbiology and BiotechnologyPseudomonas nitroreducens ATCC PTA-6168 (also named TX1) efficiently grows on non-ionic surfactants as the sole source of carbon and energy aerobically.
Lam Dinh Bui +4 more
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Biomolecules, 2021 Pyrroloquinoline quinone (PQQ) is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically relevant dysfunctions (e.g., those associated with ischemia, inflammation and ...
Karen R. Jonscher +2 more
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Discovery of a eukaryotic pyrroloquinoline quinone-dependent oxidoreductase belonging to a new auxiliary activity family in the database of carbohydrate-active enzymes. [PDF]
PLoS ONE, 2014 Pyrroloquinoline quinone (PQQ) is a redox cofactor utilized by a number of prokaryotic dehydrogenases. Not all prokaryotic organisms are capable of synthesizing PQQ, even though it plays important roles in the growth and development of many organisms ...
Hirotoshi Matsumura +9 more
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PQQ-linked extracellular glucose oxidation and chemotaxis towards this cofactor in rhizobia [PDF]
FEMS Microbiology Letters, 1996 The presence of the pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenase in several strains of different Rhizobium species and of Bradyrhizobium japonicum was investigated. It was found that most strains were only able to synthesize the apo-enzyme, whereas in three strains, Rhizobium meliloti 102F34 and Bradyrhizobium japonicum strains ...
Boiardi, J.L. +2 more
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Effects of pyrroloquinoline quinone on noise-induced and age-related hearing loss in mice
Scientific Reports, 2022 We investigated whether the oxidoreductase cofactor pyrroloquinoline quinone (PQQ) prevents noise-induced and age-related hearing loss (NIHL and ARHL) in mice.
Ying Gao +4 more
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npj Aging, 2022 The aim of this study was to investigate the effects of pyrroloquinoline quinone (PQQ), an oxidoreductase cofactor, on the H 2 O 2 -induced premature senescence model in HEI-OC1 auditory cells and to elucidate its mechanism of action in vitro. Cells were
Ying Gao +4 more
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Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. [PDF]
PLoS ONE, 2014 Therapeutic strategies designed to inhibit the activation of microglia may lead to significant advancement in the treatment of most neurodegenerative diseases.
Chongfei Yang +7 more
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High-affinity PQQ import is widespread in Gram-negative bacteria. [PDF]
Sci AdvPQQ is a soluble redox cofactor used by diverse bacteria to oxidise fuel compounds as a source of electrons for the respiratory chain. Many Gram-negative bacteria that encode PQQ-dependent enzymes do not possess the biosynthetic machinery for its ...
Munder F +4 more
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Mediators of Inflammation, 2022 The current asthma therapies are inadequate for many patients with severe asthma. Pyrroloquinoline quinone (PQQ) is a naturally-occurring redox cofactor and nutrient that can exert a multitude of physiological effects, including anti-inflammatory and ...
Zhihui Min +5 more
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