Results 21 to 30 of about 94,951 (115)

Pyrroloquinoline quinone (PQQ) inhibits lipopolysaccharide induced inflammation in part via downregulated NF-κB and p38/JNK activation in microglial and attenuates microglia activation in lipopolysaccharide treatment mice. [PDF]

PLoS ONE, 2014
Therapeutic strategies designed to inhibit the activation of microglia may lead to significant advancement in the treatment of most neurodegenerative diseases.
Chongfei Yang, Lifeng Yu, Lingbo Kong, Rui Ma, Juliang Zhang, Qingsheng Zhu, Jinyu Zhu, Dingjun Hao   +7 more
doaj   +1 more source

Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection

Acta Neuropathologica Communications, 2023
Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range.
Alessio Canovai, James R. Tribble, Melissa Jöe, Daniela Y. Westerlund, Rosario Amato, Ian A. Trounce, Massimo Dal Monte, Pete A. Williams   +7 more
doaj   +1 more source

Pyrroloquinoline Quinone Administration Alleviates Allergic Airway Inflammation in Mice by Regulating the JAK-STAT Signaling Pathway

Mediators of Inflammation, 2022
The current asthma therapies are inadequate for many patients with severe asthma. Pyrroloquinoline quinone (PQQ) is a naturally-occurring redox cofactor and nutrient that can exert a multitude of physiological effects, including anti-inflammatory and ...
Zhihui Min, Jiebai Zhou, Ruolin Mao, Bo Cui, Yunfeng Cheng, Zhihong Chen   +5 more
doaj   +1 more source

Bioelectrocatalytic activity of reconstituted peroxidase on hemin-terminated PQQ-modified electrodes

Sensors and Actuators Reports, 2022
Efficient direct electrical communication between an enzyme redox center and an electrode is of great interest from the viewpoints of application to reagentless biosensors and biofuel cells.
Kikuo Komori, Tomoki Aikawa
doaj   +1 more source

Biogenesis of the peptide-derived redox cofactor PQQ

Current Opinion in Chemical Biology, 2020
Pyrroloquinoline quinone (PQQ) is a peptide-derived redox cofactor produced by prokaryotes that also plays beneficial roles in organisms from other kingdoms.
Wen Zhu, J. Klinman
semanticscholar   +1 more source

Oral pyrroloquinoline quinone (PQQ) during pregnancy increases cardiomyocyte endowment in spontaneous IUGR guinea pigs

Journal of Developmental Origins of Health and Disease, 2023
Background: Intrauterine growth restriction (IUGR) exerts a negative impact on developing cardiomyocytes and emerging evidence suggests activation of oxidative stress pathways plays a key role in this altered development.
J. Mattern, A. Gemmell, Paige E. Allen, K. Mathers, T. Regnault, B. Stansfield   +5 more
semanticscholar   +1 more source

Biotransformation of Deoxynivalenol by a Dual-Member Bacterial Consortium Isolated from Tenebrio molitor Larval Feces

Toxins, 2023
In this study, a dual-member bacterial consortium with the ability to oxidize deoxynivalenol (DON) to 3-keto-DON, designated SD, was first screened from the feces of Tenebrio molitor larvae. This consortium consisted of Pseudomonas sp. SD17-1 and Devosia
Yang Wang, Donglei Zhao, Wei Zhang, Songxue Wang, Kai Huang, Baoyuan Guo   +5 more
doaj   +1 more source

Pyrroloquinoline Quinone (PQQ): a novel approach to managing chronic inflammatory response syndrome and mitochondrial dysfunction

Journal of Bacteriology & Mycology: Open Access, 2023
Chronic Inflammatory Response Syndrome (CIRS) is a complex, multi-system condition associated with persistent inflammation in response to biotoxins like mould or other environmental triggers.
Cameron L. Jones
semanticscholar   +1 more source

Pyrroloquinoline quinone regulates the redox status in vitro and in vivo of weaned pigs via the Nrf2/HO-1 pathway

Journal of Animal Science and Biotechnology, 2021
Background Oxidative stress is a main cause of piglet gut damage and diarrhea. Pyrroloquinoline quinone (PQQ), is a novel redox cofactor with antioxidant properties. However, the effect and mechanism that PQQ supplementation decreases oxidative injury in
Caiyun Huang, Zijuan Fan, Dandan Han, Lee J. Johnston, Xi Ma, Fenglai Wang   +5 more
doaj   +1 more source

Adaptive evolutionary strategy coupled with an optimized biosynthesis process for the efficient production of pyrroloquinoline quinone from methanol

Biotechnology for Biofuels and Bioproducts, 2023
Background Pyrroloquinoline quinone (PQQ), a cofactor for bacterial dehydrogenases, is associated with biological processes such as mitochondriogenesis, reproduction, growth, and aging.
Yang Ren, Xinwei Yang, Lingtao Ding, Dongfang Liu, Yong Tao, Jianzhong Huang, Chongrong Ke   +6 more
doaj   +1 more source