A new model for the pro-PQQ cofactor of quinoprotein methylamine dehydrogenase
FEBS Letters, 1989 A model for the pro‐PQQ cofactor of Thiobacillus versutus methylamine dehydrogenase was fitted into a 2.25 Å resolution electron density distribution for this enzyme. This proposed model of pro‐PQQ consists of a tyrosine‐derived quinone indole bicyclic structure.
Vellieux, Frederic M.D., Hol, Wim G.J.
exaly +3 more sources
Pyrroloquinoline Quinone (PQQ): Its impact on human health and potential benefits [PDF]
Current Research in Food SciencePyrroloquinoline Quinone (PQQ) is a redox-active quinone molecule with significant implications for human health. Originally identified as a bacterial cofactor, PQQ has since been lauded for its diverse biological and therapeutic activities. It serves as
Tingdong Yan +10 more
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Characterisation of the PQQ cofactor radical in quinoprotein ethanol dehydrogenase of Pseudomonas aeruginosa by electron paramagnetic resonance spectroscopy [PDF]
FEBS Letters, 2004 The binding pocket of the pyrroloquinoline quinone (PQQ) cofactor in quinoprotein alcohol dehydrogenases contains a characteristic disulphide ring formed by two adjacent cysteine residues. To analyse the function of this unusual structural motif we have investigated the wild‐type and a double cysteine:alanine mutant of the quinoprotein ethanol ...
Kay, Christopher W.M +3 more
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PQQ Dietary Supplementation Prevents Alkylating Agent-Induced Ovarian Dysfunction in Mice
Frontiers in Endocrinology, 2022 Alkylating agents (AAs) that are commonly used for cancer therapy cause great damage to the ovary. Pyrroloquinoline-quinine (PQQ), which was initially identified as a redox cofactor for bacterial dehydrogenases, has been demonstrated to benefit the ...
Xiuliang Dai +8 more
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PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation
Natural Product Communications, 2022 SARS-CoV-2 spike protein-induced heart inflammation may originate from either COVID-19 infection or the administration of COVID-19 mRNA vaccines. As pyrroloquinoline quinone (PQQ) is a scavenger of free radicals, redox cofactor, and antioxidant which ...
Alberto Boretti
doaj +2 more sources
Phenylhydrazine as probe for cofactor identification in amine oxidoreductases Evidence for PQQ as the cofactor in methylamine dehydrogenase [PDF]
FEBS Letters, 1987 Homogeneous methylamine dehydrogenase (primary‐amine:(acceptor) oxidoreductase (deaminating), EC 1.4.99.3, MADH) from the bacterium Thiobacillus versutus was treated with the inhibitor phenylhydrazine (PH). Derivatization of the cofactor in MADH took place in a fast reaction to give compound I.
van der Meer, Robert A. +2 more
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Pyrroloquinoline Quinone Mitigates Testicular Injury and Reduces Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Rats with Testicular Ischemia–Reperfusion Injury [PDF]
AntioxidantsTesticular torsion–detorsion (T/D) induces ischemia–reperfusion injury, leading to mitochondrial dysfunction, oxidative stress, apoptosis, and spermatogenic impairment.
Syuan-Hao Syu +3 more
doaj +2 more sources
Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellAs a natural senomorphic agent, PQQ targets the intracellular molecule. HSPA8 of senescent cells, resulting in significantly reduced expression of the SASP. PQQ holds prominent potential to delay chronological aging and ameliorate age‐related conditions by acting as an effective senomorphic agent.
Jiang B +6 more
europepmc +2 more sources
A Metal–Organic Hybrid Composed of Dual Quenching Cofactors as a Nanoquencher for the Fluorescent Determination of Protease Caspase-3 [PDF]
BiosensorsNanoquenchers with a single quenching cofactor exhibit limited fluorescence quenching efficiency. In this work, a metal–organic hybrid with dual quenching cofactors (Cu2+ and pyrroloquinoline quinone or PQQ) was prepared by metal-coordinated assembly and
Fengli Gao +4 more
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Journal of Animal Science and Biotechnology, 2019 Background Pyrroloquinoline quinone (PQQ), which is a water soluble, thermo-stable triglyceride-quinone, is widely distributed in nature and characterized as a mammalian vitamin-like redox cofactor.
Boru Zhang +6 more
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