Results 41 to 50 of about 13,975 (182)

Retention of prions in the polychaete Hediste diversicolor and black soldier fly, Hermetia illucens, larvae after short-term experimental immersion and feeding with brain homogenate from scrapie infected sheep

Heliyon
Finding alternative protein and lipid sources for aquafeeds is crucial for the sustainable growth of fed aquaculture. Upcycling industrial side streams and byproducts using extractive species can reduce waste and help reduce the sector's dependence on ...
Sylvie L. Benestad, Linh Tran, Arne M. Malzahn, Nina S. Liland, Ikram Belghit, Andreas Hagemann   +5 more
doaj   +1 more source

Accelerated high fidelity prion amplification within and across prion species barriers.

PLoS Pathogens, 2008
Experimental obstacles have impeded our ability to study prion transmission within and, more particularly, between species. Here, we used cervid prion protein expressed in brain extracts of transgenic mice, referred to as Tg(CerPrP), as a substrate for ...
Kristi M Green, Joaquín Castilla, Tanya S Seward, Dana L Napier, Jean E Jewell, Claudio Soto, Glenn C Telling   +6 more
doaj   +1 more source

A systematic investigation of production of synthetic prions from recombinant prion protein [PDF]

Open Biology, 2015
According to the protein-only hypothesis, infectious mammalian prions, which exist as distinct strains with discrete biological properties, consist of multichain assemblies of misfolded cellular prion protein (PrP).
Christian Schmidt, Jeremie Fizet, Francesca Properzi, Mark Batchelor, Malin K. Sandberg, Julie A. Edgeworth, Louise Afran, Sammy Ho, Anjna Badhan, Steffi Klier, Jacqueline M. Linehan, Sebastian Brandner, Laszlo L. P. Hosszu, M. Howard Tattum, Parmjit Jat, Anthony R. Clarke, Peter C. Klöhn, Jonathan D. F. Wadsworth, Graham S. Jackson, John Collinge   +19 more
doaj   +1 more source

Stage‐Dependent β‐Synuclein Links MRI and Cognitive Decline in Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Synaptic degeneration drives cognitive decline in Alzheimer's disease (AD), but synaptic biomarkers are scarce. Brain‐enriched β‐synuclein emerged as a synaptic damage marker. We investigated its diagnostic, prognostic, and structural correlates across the AD continuum.
Ulaş Ay, Merve Alaylioglu, Erdi Sahin, Sanem Sultan Yoruk Oner, Gulce Iskan, Gulce Cosku Yilmaz Cakan, Gozde Kizilates‐Evin, Emre Hari, Elif Kurt, Erdinc Dursun, Basar Bilgic, Hasmet Hanagasi, Hakan Gurvit, Tamer Demiralp, Duygu Gezen‐Ak, Bedia Samanci   +15 more
wiley   +1 more source

Recomendações para prevenção e controle da disseminação intra-hospitalar de príons: uma revisão bibliográfica

Revista SOBECC, 2006
As  encef a lopatias  espon­ gifo rme s transmissíveis são causadas por príons e acometem a nima is e humanos . A recente epidemia, ocorrida  em 1986, no Reino Unido, atingiu aproxi­ madamente   200              mil   bovinos   que receberam ...
Vania Regina Goveia, Giovana Abrahão Araújo a Moriya, Simone Batista Neto, Rúbia Aparecida Lacerda, Kazuko Uchikawa Graziano   +4 more
doaj  

Preclinical Detection of Prions in Blood of Nonhuman Primates Infected with Variant Creutzfeldt-Jakob Disease

Emerging Infectious Diseases, 2020
Variant Creutzfeldt-Jakob disease (vCJD) is caused by prion infection with bovine spongiform encephalopathy and can be transmitted by blood transfusion. Protein misfolding cyclic amplification (PMCA) can detect prions in blood from vCJD patients with 100%
Luis Concha-Marambio, Marcelo A. Chacon, Claudio Soto   +2 more
doaj   +1 more source

Rapid antemortem detection of CWD prions in deer saliva. [PDF]

PLoS ONE, 2013
Chronic wasting disease (CWD) is an efficiently transmitted prion disease of cervids, now identified in 22 United States, 2 Canadian provinces and Korea.
Davin M Henderson, Matteo Manca, Nicholas J Haley, Nathaniel D Denkers, Amy V Nalls, Candace K Mathiason, Byron Caughey, Edward A Hoover   +7 more
doaj   +1 more source

A 3D Human Neuron‐on‐Chip Platform to Monitor Neuronal Injury Responses

Advanced Healthcare Materials, EarlyView.
This study presents a novel 3D Neuron‐on‐Chip model that can maintain human PSC‐derived excitatory prefrontal cortex neurons in 3D hydrogels and can be used to monitor neuronal injury responses over time. Results show injury‐induced acute neuronal excitotoxicity, declining neuronal connectivity, and the activation of a neurodegenerative, SASP‐like ...
Ruiping Tang, Charles‐Francois Latchoumane, Avi Chopra, Md Marzan Sarkar, Chunki Kim, Nathan Gonsalves, Hsueh‐Fu Wu, John C. Sentmanat, Alan Liu, Isha Mhatre‐Winters, Aditya Mishra, Andrei G. Fedorov, Jay M. Patel, Nadja Zeltner, Steven L. Stice, Jason R. Richardson, Lohitash Karumbaiah   +16 more
wiley   +1 more source

Acquisition of drug resistance and dependence by prions. [PDF]

PLoS Pathogens, 2013
We have reported that properties of prion strains may change when propagated in different environments. For example, when swainsonine-sensitive 22L prions were propagated in PK1 cells in the presence of swainsonine, drug-resistant variants emerged.
Anja M Oelschlegel, Charles Weissmann
doaj   +1 more source

De Novo Autogenic Engineered Living Functional Materials

Advanced Materials, EarlyView.
A versatile platform for de novo autogenic engineered living materials is presented, leveraging protein mining, computational modeling, and synthetic biology. By reprogramming the Escherichia coli curli machinery with β‐solenoid proteins from non‐model bacteria, macroscopic biomaterials with enhanced mechanical properties, UV‐C irradiation protection ...
Hoda M. Hammad, Seth Swarnadeep, Erin C. Jackson, Nicolas Burns, Hongyu Wang, Harrison Priode, Robert B. Moore, Sanket Deshmukh, Avinash Manjula‐Basavanna, Anna M. Duraj‐Thatte   +9 more
wiley   +1 more source