Results 21 to 30 of about 13,975 (182)

Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting. [PDF]

PLoS Pathogens, 2015
Prions enter the environment from infected hosts, bind to a wide range of soil and soil minerals, and remain highly infectious. Environmental sources of prions almost certainly contribute to the transmission of chronic wasting disease in cervids and ...
Qi Yuan, Thomas Eckland, Glenn Telling, Jason Bartz, Shannon Bartelt-Hunt   +4 more
doaj   +1 more source

Aerosols transmit prions to immunocompetent and immunodeficient mice. [PDF]

PLoS Pathogens, 2011
Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not generally considered to be airborne.
Johannes Haybaeck, Mathias Heikenwalder, Britta Klevenz, Petra Schwarz, Ilan Margalith, Claire Bridel, Kirsten Mertz, Elizabeta Zirdum, Benjamin Petsch, Thomas J Fuchs, Lothar Stitz, Adriano Aguzzi   +11 more
doaj   +1 more source

Conformational diversity in purified prions produced in vitro.

PLoS Pathogens, 2023
Prion diseases are caused by misfolding of either wild-type or mutant forms of the prion protein (PrP) into self-propagating, pathogenic conformers, collectively termed PrPSc.
Daniel J Walsh, Abigail M Schwind, Geoffrey P Noble, Surachai Supattapone   +3 more
doaj   +1 more source

Tracking and clarifying differential traits of classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys.

PLoS ONE, 2019
Classical- (C-) and atypical L-type bovine spongiform encephalopathy (BSE) prions cause different pathological phenotypes in cattle brains, and the disease-associated forms of each prion protein (PrPSc) has a dissimilar biochemical signature.
Ken'ichi Hagiwara, Yuko Sato, Yoshio Yamakawa, Hideyuki Hara, Minoru Tobiume, Yuko Okemoto-Nakamura, Tetsutaro Sata, Motohiro Horiuchi, Hiroaki Shibata, Fumiko Ono   +9 more
doaj   +1 more source

Improving the Predictive Value of Prion Inactivation Validation Methods to Minimize the Risks of Iatrogenic Transmission With Medical Instruments

Frontiers in Bioengineering and Biotechnology, 2020
Prions are pathogenic infectious agents responsible for fatal, incurable neurodegenerative diseases in animals and humans. Prions are composed exclusively of an aggregated and misfolded form (PrPSc) of the cellular prion protein (PrPC).
Mohammed Moudjou, Johan Castille, Bruno Passet, Laetitia Herzog, Fabienne Reine, Jean-Luc Vilotte, Human Rezaei, Vincent Béringue, Angélique Igel-Egalon, Angélique Igel-Egalon   +9 more
doaj   +1 more source

Identification of chronic wasting disease prions in decaying tongue tissues from exhumed white-tailed deer

mSphere, 2023
Chronic wasting disease (CWD) prions cause fatal neuropathies in farmed and free-ranging cervids. The deposition of prions in natural and humanmade environmental components has been implicated as a major mechanism mediating CWD spread in wild and captive
Paulina Soto, Francisca Bravo-Risi, Rebeca Benavente, Stuart Lichtenberg, Mitch Lockwood, J. Hunter Reed, Rodrigo Morales   +6 more
doaj   +1 more source

The Way forward for the Origin of Life: Prions and Prion-Like Molecules First Hypothesis

Life, 2021
In this paper the hypothesis that prions and prion-like molecules could have initiated the chemical evolutionary process which led to the eventual emergence of life is reappraised.
Sohan Jheeta, Elias Chatzitheodoridis, Kevin Devine, Janice Block   +3 more
doaj   +1 more source

High phenotypic variability in Gerstmann-Sträussler-Scheinker disease

Arquivos de Neuro-Psiquiatria
Gerstmann-Sträussler-Scheinker is a genetic prion disease and the most common mutation is p.Pro102Leu. We report clinical, molecular and neuropathological data of seven individuals, belonging to two unrelated Brazilian kindreds, carrying the p.Pro102Leu.
Jerusa Smid, Adalberto Studart Neto, Michele Christine Landemberger, Cleiton Fagundes Machado, Paulo Ribeiro Nóbrega, Nathalie Henriques Silva Canedo, Rodrigo Rizek Schultz, Michel Satya Naslavsky, Sérgio Rosemberg, Fernando Kok, Leila Chimelli, Vilma Regina Martins, Ricardo Nitrini   +12 more
doaj   +1 more source

Artificial strain of human prions created in vitro

Nature Communications, 2018
Synthetic prions have previously been generated from recombinant rodent PrP. Here the authors generate synthetic human prions, by seeding human PrP with CJD prions, and characterize its infectivity in mice.
Chae Kim, Xiangzhu Xiao, Shugui Chen, Tracy Haldiman, Vitautas Smirnovas, Diane Kofskey, Miriam Warren, Krystyna Surewicz, Nicholas R. Maurer, Qingzhong Kong, Witold Surewicz, Jiri G. Safar   +11 more
doaj   +1 more source

Sensitive detection of chronic wasting disease prions recovered from environmentally relevant surfaces

Environment International, 2022
Chronic wasting disease (CWD) has been identified in 30 states in the United States, four provinces in Canada, and recently emerged in Scandinavia. The association of CWD prions with environmental materials such as soil, plants, and surfaces may enhance ...
Qi Yuan, Gage Rowden, Tiffany M. Wolf, Marc D. Schwabenlander, Peter A. Larsen, Shannon L. Bartelt-Hunt, Jason C. Bartz   +6 more
doaj   +1 more source