Results 1 to 10 of about 963 (50)
Resistance of bovine spongiform encephalopathy (BSE) prions to inactivation. [PDF]
PLoS Pathogens, 2008 Distinct prion strains often exhibit different incubation periods and patterns of neuropathological lesions. Strain characteristics are generally retained upon intraspecies transmission, but may change on transmission to another species.
Kurt Giles +6 more
doaj +1 more source
Reduction of Chronic Wasting Disease Prion Seeding Activity following Digestion by Mountain Lions
mSphere, 2021 Chronic wasting disease (CWD) is a transmissible prion disease first observed in the 1960s in North America. This invariably fatal disease affects multiple cervid species in the wild and in captivity.
Chase Baune +6 more
doaj +1 more source
Scientific Reports, 2021 Misfolding of the cellular prion protein, PrPC, into the amyloidogenic isoform, PrPSc, which forms infectious protein aggregates, the so-called prions, is a key pathogenic event in prion diseases.
Hideyuki Hara +6 more
doaj +1 more source
Hsp40/JDP Requirements for the Propagation of Synthetic Yeast Prions
Viruses, 2022 Yeast prions are protein-based transmissible elements, most of which are amyloids. The chaperone protein network in yeast is inexorably linked to the spreading of prions during cell division by fragmentation of amyloid prion aggregates. Specifically, the
Sarah C. Miller +5 more
doaj +1 more source
ANÁLISE BIBLIOGRÁFICA: PROTEÍNA PRÍON E ENCEFALOPATIAS TRANSMISSÍVEIS
Revista de Ciências da Saúde Nova Esperança, 2020 As doenças priônicas são enfermidades neurodegenerativas raras que causam diversos sintomas neuropsiquiátricos devido ao acúmulo de príons, pequenas partículas resistentes à inativação formadas por genes que se modificam originando proteínas mutantes ...
Ruri Miranda Machado +2 more
doaj +1 more source
Avaliação epidemiológica dos óbitos por doenças priônicas no Brasil sob o enfoque da biossegurança
Cadernos de Saúde Coletiva, 2015 A emergência e a reemergência das doenças infecciosas oferece desafios à saúde pública, gerando demandas para os governos e para a comunidade científica; o que leva à priorização de ações em saúde, estabelecimento de políticas, aprimoramento da ...
Camila Abdalla de Oliveira Cardoso +3 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2023 Prion diseases are a group of infectious neurodegenerative diseases produced by the conversion of the normal prion protein (PrPC) into the disease-associated form (PrPSc).
Luis Concha-Marambio +9 more
doaj +1 more source
Disaggregases, molecular chaperones that resolubilize protein aggregates
Anais da Academia Brasileira de Ciências, 2015 The process of folding is a seminal event in the life of a protein, as it is essential for proper protein function and therefore cell physiology. Inappropriate folding, or misfolding, can not only lead to loss of function, but also to the formation of ...
David Z. Mokry +2 more
doaj +1 more source
Resistance of soil-bound prions to rumen digestion. [PDF]
PLoS ONE, 2012 Before prion uptake and infection can occur in the lower gastrointestinal system, ingested prions are subjected to anaerobic digestion in the rumen of cervids and bovids.
Samuel E Saunders +2 more
doaj +1 more source
Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells. [PDF]
PLoS ONE, 2017 In our previous study, we demonstrated the propagation of mouse-passaged scrapie isolates with long incubation periods (L-type) derived from natural Japanese sheep scrapie cases in murine hypothalamic GT1-7 cells, along with disease-associated prion ...
Kohtaro Miyazawa +5 more
doaj +1 more source