Results 11 to 20 of about 13,975 (182)

Distinct prion conformers from brain and peripheral tissues of gene-targeted mice produce convergent CWD strain properties. [PDF]

PLoS Pathogens
Prions are unique infectious agents because different conformational properties of their constituent proteins are responsible for the manifestation of distinct strains.
Joseph P DeFranco, Zoe N Atkinson, Jenna Crowell, Xutong Shi, Sehun Kim, Julianna L Sun, Sarah J Kane, Glenn C Telling   +7 more
doaj   +2 more sources

Infectious prions in brains and muscles of domestic pigs experimentally challenged with the BSE, scrapie, and CWD agents [PDF]

mBio
Experimental studies suggest that animal species not previously described as naturally infected by prions are susceptible to prion diseases affecting sheep, cattle, and deer.
Francisca Bravo-Risi, Fraser Brydon, Angela Chong, Kane Spicker, Justin J. Greenlee, Glenn Telling, Claudio Soto, Sandra Pritzkow, Marcelo A. Barria, Rodrigo Morales   +9 more
doaj   +2 more sources

Distribution of chronic wasting disease (CWD) prions in tissues from experimentally exposed coyotes (Canis latrans). [PDF]

PLoS ONE
Cervids susceptible to chronic wasting disease (CWD) are sympatric with multiple other animal species that can interact with infectious prions. Several reports have described the susceptibility of other species to CWD prions, or their potential to ...
Nancy Ho, Reece McGinn, Paulina Soto, Terry R Spraker, Justin Fischer, Kurt VerCauteren, Tracy Nichols, Rodrigo Morales   +7 more
doaj   +2 more sources

Impacto da recusa de candidatos à doação de sangue devido aos critérios para prevenção da doença de Creutzfeldt-Jacob e sua variante Impact of deferral criteria on prevention of Creutzfeldt-Jakob disease and its variant among blood donors in São Paulo, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2005
A doença de Creutzfeldt-Jacob (CJD) e sua variante (vCJD) são doenças neurológicas fatais, degenerativas, com longo período de incubação. Recentemente, um possível caso de transmissão de vCJD por transfusão sangüínea foi descrito.
Cesar Almeida Neto, Alfredo Mendrone Júnior, Anésio Vieira, Pedro E. Dorlhiac-Llacer, Dalton AF Chamone   +4 more
doaj   +1 more source

Defining the conformational features of anchorless, poorly neuroinvasive prions. [PDF]

PLoS Pathogens, 2013
Infectious prions cause diverse clinical signs and form an extraordinary range of structures, from amorphous aggregates to fibrils. How the conformation of a prion dictates the disease phenotype remains unclear.
Cyrus Bett, Tim D Kurt, Melanie Lucero, Margarita Trejo, Annemieke J Rozemuller, Qingzhong Kong, K Peter R Nilsson, Eliezer Masliah, Michael B Oldstone, Christina J Sigurdson   +9 more
doaj   +1 more source

Efficient interspecies transmission of synthetic prions.

PLoS Pathogens, 2021
Prions are comprised solely of PrPSc, the misfolded self-propagating conformation of the cellular protein, PrPC. Synthetic prions are generated in vitro from minimal components and cause bona fide prion disease in animals.
Alyssa J Block, Ronald A Shikiya, Thomas E Eckland, Anthony E Kincaid, Ryan W Walters, Jiyan Ma, Jason C Bartz   +6 more
doaj   +1 more source

Doenças priônicas: avaliação dos riscos envolvidos na utilização de produtos de origem bovina Prionic disease: evaluation of the risks involved in using products of bovine origin

Anais Brasileiros de Dermatologia, 2003
Os príons são proteínas que se mostram capazes de auto-replicação apesar de, para isso, alterar o metabolismo celular. São responsáveis por inúmeras doenças em animais e no ser humano (doenças priônicas), todas elas fatais.
Omar Lupi
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Protease-sensitive synthetic prions. [PDF]

PLoS Pathogens, 2010
Prions arise when the cellular prion protein (PrP(C)) undergoes a self-propagating conformational change; the resulting infectious conformer is designated PrP(Sc).
David W Colby, Rachel Wain, Ilia V Baskakov, Giuseppe Legname, Christina G Palmer, Hoang-Oanh B Nguyen, Azucena Lemus, Fred E Cohen, Stephen J DeArmond, Stanley B Prusiner   +9 more
doaj   +1 more source

Plants as vectors for environmental prion transmission

iScience, 2023
Summary: Prions cause fatal neurodegenerative diseases and exhibit remarkable durability, which engenders a wide array of potential exposure scenarios. In chronic wasting disease of deer, elk, moose, and reindeer and in scrapie of sheep and goats, prions
Christina M. Carlson, Samuel Thomas, Matthew W. Keating, Paulina Soto, Nicole M. Gibbs, Haeyoon Chang, Jamie K. Wiepz, Annabel G. Austin, Jay R. Schneider, Rodrigo Morales, Christopher J. Johnson, Joel A. Pedersen   +11 more
doaj   +1 more source