Results 51 to 60 of about 1,577,570 (335)

Meeting pragmatism halfway: making a pragmatic clinical trial protocol [PDF]

Sociology of Health & Illness, 2015
AbstractPragmatic clinical trials (PCTs) are today an increasingly prominent means of measuring the ‘effectiveness’ of healthcare interventions in ‘real world’ clinical settings, in order to produce evidence on which to base regulatory and clinical decision‐making.
openaire   +3 more sources

Ethics and Collateral Findings in Pragmatic Clinical Trials

American Journal of Bioethics, 2020
Pragmatic clinical trials (PCTs) offer important benefits, such as generating evidence that is suited to inform real-world health care decisions and increasing research efficiency. However, PCTs also present ethical challenges.
Stephanie R. Morain, K. Weinfurt, Juli M. Bollinger, G. Geller, Debra J. H. Mathews, J. Sugarman   +5 more
semanticscholar   +1 more source

Understanding implementability in clinical trials: a pragmatic review and concept map

Trials, 2021
Background The translation of evidence from clinical trials into practice is complex. One approach to facilitating this translation is to consider the ‘implementability’ of trials as they are designed and conducted.
Miranda S. Cumpston, Steven A. Webb, Philippa Middleton, Greg Sharplin, Sally Green, for the Australian Clinical Trials Alliance Reference Group on Impact and Implementation of CTN Trials   +5 more
doaj   +1 more source

A pragmatic, multi-centered, stepped wedge, cluster randomized controlled trial pilot of the clinical and cost effectiveness of a complex Stroke Oral healthCare intervention pLan Evaluation II (SOCLE II) compared with usual oral healthcare in stroke wards [PDF]

, 2019
BACKGROUND: Patients with stroke-associated pneumonia experience poorer outcomes (increased hospital stays, costs, discharge dependency, and risk of death).
Bain, Brenda Jean, Barr, John, Bowers, Naomi, Brady, Marian C., Chalmers, Campbell, Colins, Marissa, Gray, Heather, Keerie, Catriona, Langhorne, Peter, Pollock, Alex, Stott, David J., Sweeney, Petrina, Weir, Christopher J.   +12 more
core   +2 more sources

Design and analytic considerations for using patient-reported health data in pragmatic clinical trials: report from an NIH Collaboratory roundtable

J. Am. Medical Informatics Assoc., 2020
Pragmatic clinical trials often entail the use of electronic health record (EHR) and claims data, but bias and quality issues associated with these data can limit their fitness for research purposes particularly for study end points.
F. Rockhold, J. Tenenbaum, R. Richesson, Keith A. Marsolo, Emily C. O'Brien   +4 more
semanticscholar   +1 more source

Double-blind randomised controlled trial of percutaneous tibial nerve stimulation versus sham electrical stimulation in the treatment of faecal incontinence: CONtrol of Faecal Incontinence using Distal NeuromodulaTion (the CONFIDeNT trial)

Health Technology Assessment, 2015
Background: Faecal incontinence (FI) is a common condition which is often under-reported. It is distressing for those suffering from it, impacting heavily on their quality of life.
Emma J Horrocks, Stephen A Bremner, Natasha Stevens, Christine Norton, Deborah Gilbert, P Ronan O’Connell, Sandra Eldridge, Charles H Knowles   +7 more
doaj   +1 more source

Stepped-wedge randomised trial of laparoscopic ventral mesh rectopexy in adults with chronic constipation: study protocol for a randomized controlled trial

Trials, 2018
Background Laparoscopic ventral mesh rectopexy (LVMR) is an established treatment for external full-thickness rectal prolapse. However, its clinical efficacy in patients with internal prolapse is uncertain due to the lack of high-quality evidence ...
Ugo Grossi, Natasha Stevens, Eleanor McAlees, Jon Lacy-Colson, Steven Brown, Anthony Dixon, Gian Luca Di Tanna, S. Mark Scott, Christine Norton, Nadine Marlin, James Mason, Charles H. Knowles, On behalf of the NIHR CapaCiTY working group   +12 more
doaj   +1 more source

The Knee Arthroplasty Trial (KAT) : design features, baseline characteristics and two-year functional outcomes after alternative approaches to knee replacement [PDF]

, 2009
Background: The aim of continued development of total knee replacement systems has been the further improvement of the quality of life and increasing the duration of prosthetic survival.
Campbell, Marion Kay, Fiddian, Nick, Fitzpatrick, Ray, Grant, Adrian Maxwell, Gray, Alastair, Johnston, Linda, KAT Trial Group, MacLennan, Graeme Stewart, McCormack, Kirsty, Morris, Richard, Murray, David, Ramsay, Craig R, Rowley, David, Walker, Allan   +13 more
core   +1 more source

Using Healthcare Data in Embedded Pragmatic Clinical Trials among People Living with Dementia and Their Caregivers: State of the Art

Journal of The American Geriatrics Society, 2020
Embedded pragmatic clinical trials (ePCTs) are embedded in healthcare systems as well as their data environments. For people living with dementia (PLWD), settings of care can be different from the general population and involve additional people whose ...
J. Bynum, D. Dorr, Julie C. Lima, E. McCarthy, E. McCreedy, R. Platt, V.G.Vinod Vydiswaran   +6 more
semanticscholar   +1 more source

Pragmatic clinical trials

Complementary Therapies in Medicine, 2004
Both pragmatic and explanatory randomised controlled trials have a useful role to play in the evaluation of health care interventions. In this descriptive article, the key steps in conducting a pragmatic trial are described. The strengths and limitations of pragmatic trials are also discussed.
openaire   +2 more sources