Results 61 to 70 of about 1,577,570 (335)

Acupuncture in Seasonal Allergic Rhinitis (ACUSAR) - Design and Protocol of a Randomised Controlled Multi-Centre Trial [PDF]

, 2010
Background: We report on the study design and protocol of a randomised controlled trial (Acupuncture in Seasonal Allergic Rhinitis, ACUSAR) that investigates the efficacy of acupuncture in the treatment of seasonal allergic rhinitis (SAR).
Brinkhaus, Benno, Hummelsberger, Josef, Irnich, Dominik, Linde, Klaus, Niggemann, Bodo, Ortiz, Miriam, Pfab, Florian, Reinhold, Thomas, Roll, Stephanie, Wegscheider, Karl, Willich, Stefan N., Witt, Claudia M.   +11 more
core   +1 more source

Fluid Optimisation in Emergency Laparotomy (FLO-ELA) Trial: study protocol for a multi-centre randomised trial of cardiac output-guided fluid therapy compared to usual care in patients undergoing major emergency gastrointestinal surgery

Trials, 2023
Introduction Postoperative morbidity and mortality in patients undergoing major emergency gastrointestinal surgery are a major burden on healthcare systems.
Mark R. Edwards, Gordon Forbes, Neil Walker, Dion G. Morton, Monty G. Mythen, Dave Murray, Iain Anderson, Borislava Mihaylova, Ann Thomson, Matt Taylor, Marianne Hollyman, Rachel Phillips, Keith Young, Brennan C. Kahan, Rupert M. Pearse, Michael P. W. Grocott, for the FLO-ELA investigators   +16 more
doaj   +1 more source

Evaluating the design and reporting of pragmatic trials in osteoarthritis research [PDF]

Objectives. Among the challenges in health research is translating interventions from controlled experimental settings to clinical and community settings where chronic disease is managed daily. Pragmatic trials offer a method for testing interventions in
Ali, SA, Fitzsimmons, DA, Kloseck, M, Lee, K, MacDermid, JC, Walsh, KE   +5 more
core   +1 more source

Engaging Stakeholders in the Design and Conduct of Embedded Pragmatic Clinical Trials for Alzheimer’s Disease and Alzheimer’s Disease–Related Dementias

Journal of The American Geriatrics Society, 2020
Embedded pragmatic clinical trials (ePCTs) of nondrug interventions for Alzheimer’s disease and Alzheimer’s disease–related dementias (AD/ADRD) are conducted in real‐world clinical settings and designed to generate an evidence base to inform clinical and
J. Harrison, K. Maslow, E. Tambor, Louise Phillips, Lori Frank, L. Herndon, G. Epstein-Lubow   +6 more
semanticscholar   +1 more source

Interactive group-based orientation sessions: A method to improve adherence and retention in pragmatic clinical trials

Contemporary Clinical Trials Communications, 2020
Background Intervention adherence and trial retention are challenging for clinical trials testing intensive behavioral interventions. Operational constraints or trial designs may preclude using effective retention strategies such as financial incentives.
M. Mayhew, M. Leo, W. Vollmer, L. DeBar, M. Kiernan   +4 more
semanticscholar   +1 more source

Levosimendan in Sepsis. [PDF]

, 2017
Commentum to "Levosimendan for the Prevention of Acute Organ Dysfunction in ...
Morelli, Andrea, Tritapepe, Luigi
core   +1 more source

One size does not fit all: Insights for engaging front‐line clinicians in pragmatic clinical trials

Learning Health Systems, 2020
Despite the proliferation of pragmatic clinical trials (PCTs) conducted in health care delivery settings, we know relatively little about how practicing clinicians perceive their potential roles in such research. Empirical evidence and practical guidance
E. Tambor, R. Moloney, Sarah M Greene
semanticscholar   +1 more source

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]

, 2015
Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D, Bainbridge, A, Cady, E, Charles-Edwards, G, Deierl, A, Edwards, AD, Fagiolo, G, Franks, NP, Griffiths, J, Hajnal, J, Juszczak, E, Kapetanakis, B, Linsell, L, Maze, M, Omar, O, Robertson, NJ, Strohm, B, Tusor, N   +17 more
core   +2 more sources

Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults with inflammatory bowel disease (IBD-BOOST): study protocol for a randomised controlled trial

Trials, 2021
Background Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life.
Christine Norton, Jonathan Syred, Sally Kerry, Micol Artom, Louise Sweeney, Ailsa Hart, Wladyslawa Czuber-Dochan, Stephanie J. C. Taylor, Borislava Mihaylova, Chris Roukas, Qasim Aziz, Laura Miller, Richard Pollok, Sonia Saxena, Imogen Stagg, Helen Terry, Zohra Zenasni, Lesley Dibley, Rona Moss-Morris   +18 more
doaj   +1 more source

"Targeted" Consent for Pragmatic Clinical Trials [PDF]

Journal of General Internal Medicine, 2015
Research on interventions within the standard of care has enormous potential, yet it also raises several ethical and regulatory challenges. Perhaps the most important is determining what consent process is needed for these "pragmatic" clinical trials. Some argue that pragmatic clinical trials need to obtain in-depth research consent.
openaire   +2 more sources