Results 81 to 90 of about 1,577,570 (335)

Evidence of comparative efficacy should have a formal role in European drug approvals [PDF]

, 2011
Despite methodological concerns, comparative efficacy evidence should be required at the time of drug approval, says Corinna Sorenson and colleagues, to allow patients, clinicians, and other healthcare decision makers to determine whether a new drug is ...
Cylus, Jonathan, Mossialos, Elias, Naci, Huseyin, Sorenson, Corinna   +3 more
core   +1 more source

Designing Trials with Purpose: Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management.

Pain medicine (Malden, Mass.), 2020
OBJECTIVE Pain is one of the most significant causes of morbidity and disability worldwide. The efficacy of several nonpharmacological approaches for pain management has been established, but significant gaps exist between this evidence and their limited
K. Gordon, P. Peduzzi, R. Kerns
semanticscholar   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK) [PDF]

, 2015
Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid ...
B Ambuel, B Blackwood, B Blackwood, B Blackwood, B Blackwood, Bronagh Blackwood, C Maloney, CJL Newth, D Bieri, D Macrae, DL Jackson, E Ista, E Ista, F Frutos-Vivar, FK Foronda, FW Moler, J Rycroft-Malone, J Rycroft-Malone, J Rycroft-Malone, JA Durlak, K Harron, L Kohn, L Rose, LS Franck, Lyvonne Tume, M Cunliffe, NJ Vet, P O’Halloran, PA Jouvet, RP Dellinger, S Chawla, S Playfor, SI Merkel, SW Krechel, YN Poh   +34 more
core   +1 more source

Dissemination of trial results to participants in phase III pragmatic clinical trials: an audit of trial investigators intentions

BMJ Open, 2020
Objective To determine the proportion of Phase III clinical trials given a favourable opinion by a research ethics committee in the UK that provided trial results to those who participated. Design Audit of records.
M. Raza, H. Bruhn, K. Gillies
semanticscholar   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Using systematic data categorisation to quantify the types of data collected in clinical trials: the DataCat project

Trials, 2020
Background Data collection consumes a large proportion of clinical trial resources. Each data item requires time and effort for collection, processing and quality control procedures.
Evelyn Crowley, Shaun Treweek, Katie Banister, Suzanne Breeman, Lynda Constable, Seonaidh Cotton, Anne Duncan, Adel El Feky, Heidi Gardner, Kirsteen Goodman, Doris Lanz, Alison McDonald, Emma Ogburn, Kath Starr, Natasha Stevens, Marie Valente, Gordon Fernie   +16 more
doaj   +1 more source

The challenges faced in the design, conduct and analysis of surgical randomised trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the ...
Cook, Jonathan Alistair
core  

Self-Hypnosis for Intrapartum Pain management (SHIP) in pregnant nulliparous women: a randomised controlled trial of clinical effectiveness [PDF]

, 2015
Objective: (Primary): to establish the effect of antenatal group self-hypnosis for nulliparous women on intra-partum epidural use Design: Multi-method RCT Setting: Three NHS Trusts Population: Nulliparous women not planning elective caesarean,
Ali, Shehzad, Diggle, Peter, Downe, Soo, Finlayson, Kenneth, Gyte, Gill, Hinder, Susan, Melvin, Cathie, Miller, Vivien, Slade, Pauline, Spiby, Helen, Treppel, Dominic, Weeks, Andrew, Whorwell, Peter, Williamson, Maria   +13 more
core   +3 more sources

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source