Results 1 to 10 of about 79,378 (235)

The evolving role of data & safety monitoring boards for real-world clinical trials

Journal of Clinical and Translational Science, 2023
Introduction: Clinical trials provide the “gold standard” evidence for advancing the practice of medicine, even as they evolve to integrate real-world data sources.
Bryan J. Bunning, Haley Hedlin, Jonathan H. Chen, Jody D. Ciolino, Johannes Opsahl Ferstad, Emily Fox, Ariadna Garcia, Alan Go, Ramesh Johari, Justin Lee, David M. Maahs, Kenneth W. Mahaffey, Krista Opsahl-Ong, Marco Perez, Kaylin Rochford, David Scheinker, Heidi Spratt, Mintu P. Turakhia, Manisha Desai   +18 more
doaj   +1 more source

Neuroethical implications of focused ultrasound for neuropsychiatric illness

Brain Stimulation, 2023
Background: MR-guided focused ultrasound is a promising intervention for treatment-resistant mental illness, and merits contextualized ethical exploration in relation to more extensive ethical literature regarding other psychosurgical and neuromodulation
Rachel Asher, Insoo Hyun, Mitchell Head, G. Rees Cosgrove, David Silbersweig   +4 more
doaj   +1 more source

Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study [PDF]

Diabetes & Metabolism Journal, 2015
BackgroundThe Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control with oral hypoglycemic agents (
Sang Soo Kim, In Joo Kim, Yong Ki Kim, Kun Ho Yoon, Ho Young Son, Sung Woo Park, Yeon Ah Sung, Hong Sun Baek   +7 more
doaj   +1 more source

The Geriatric Emergency Care Applied Research (GEAR) network approach: a protocol to advance stakeholder consensus and research priorities in geriatrics and dementia care in the emergency department

BMJ Open, 2022
Introduction Increasingly, older adults are turning to emergency departments (EDs) to address healthcare needs. To achieve these research demands, infrastructure is needed to both generate evidence of intervention impact and advance the development of ...
, Shan Liu, John Morris, Cynthia Brandt, Eric Isaacs, Lynne Richardson, David Carr, Kathleen Kelly, Marian Betz, Jon Mark Hirshon, Maria Raven, Jin Han, Maura Kennedy, Manish Shah, Andrea Gilmore-Bykovskyi, Sunday Clark, Kevin Biese, Adriane Lesser, Kelly Ko, Mark Rosenberg, Ula Hwang, Christopher Carpenter, Ryan Carnahan, Susan Hastings, Daniel Wei, Vincent Mor, Denise Nassisi, William Perry, Connor Sullivan, Scott Dresden, Jeffrey Dussetschleger, Angela Gifford, Ly Hoang, Jesseca Leggett, Armin Nowroozpoor, Zachary Taylor, M Fernando Bellolio, Christine Binkley, Nicolas Bott, Abraham Brody, Savannah Forester, Cameron Gettel, Elizabeth Goldberg, Allyson Greenberg, Nada Hammouda, Nicole S Hastings, Teresita Hogan, William Hung, Jay Kayser, Elizabeth Linton, Aaron Malsch, Carmen Morano Don Melady, Nancy Morrow-Howell, Lori Nerbonne, Sylvie Nyamu, Ugochi Ohuabunwa, Timothy Platts-Mills, Luna Ragsdale, Thom Ringer, Anthony Rosen, Rachel Skains, Stephanie Skees, Kimberly Souffront, Laura Stabler, Joseph Suyama, Samuel Vargas, E Camille Vaughan, Corrine Voils, Heather Allore, Amy Aloysi, Michael Belleville, M Fernanda Bellolio, Jennie Chin-Hansen, Morgan Daven, Nida Degesys, Michael Ellenbogen, Marcus Escobedo, Jason Falvey, Thomas Gill, James Hardy, Amy JH Kind, Caitlin Malicki, Michael Malone, Richard Marottoli, Michelle Moccia, Nancy Morrow Howell, Brenda Oiyemhonlan, Kristin Rising, Mary Sano, Conor Sullivan, Joe Suyama, Jeremy Swartzberg, Vaishal Tolia, Allan Vann, Sandra Weintraub, Susan Zieman   +95 more
doaj   +1 more source

Time management: Improving the timing of post-prostatectomy radiotherapy, clinical trials, and knowledge translation

Clinical and Translational Radiation Oncology, 2021
Background: Management of prostate cancer after surgery is controversial. Past studies on adjuvant radiotherapy (aRT) for higher-risk features have had conflicting results.
Kai Yun Ooi, Ian Pereira, Himanshu Nagar, Richard Simcock, Matthew S. Katz, Christopher C. Parker, Colleen Lawton, Hina Saeed   +7 more
doaj   +1 more source

INTEnsive care bundle with blood pressure reduction in acute cerebral hemorrhage trial (INTERACT3): study protocol for a pragmatic stepped-wedge cluster-randomized controlled trial

Trials, 2021
Background Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the treatment effects by approach to ...
Lili Song, Xin Hu, Lu Ma, Xiaoying Chen, Menglu Ouyang, Laurent Billot, Qiang Li, Paula Muñoz-Venturelli, Carlos Abanto, Octavio Marques Pontes-Neto, Arauz Antonio, Mohammad Wasay, Asita de Silva, Nguyen Huy Thang, Jeyaraj Durai Pandian, Kolawole Wasiu Wahab, Chao You, Craig S. Anderson, for the INTERACT3 investigators   +18 more
doaj   +1 more source

Treatment of Hidradenitis Suppurativa Evaluation Study: the THESEUS prospective cohort study

Health Technology Assessment, 2023
Background Hidradenitis suppurativa is a chronic inflammatory skin disease characterised by recurrent inflammatory lesions and skin tunnels in flexural sites such as the axilla.
John R Ingram, Janine Bates, Rebecca Cannings-John, Fiona Collier, Angela Gibbons, Ceri Harris, Kerenza Hood, Laura Howells, Rachel Howes, Paul Leighton, Muhammad Riaz, Jeremy Rodrigues, Helen Stanton, Kim S Thomas, Emma Thomas-Jones   +14 more
doaj   +1 more source

Symptom, alexithymia and self-image outcomes of Mentalisation-based treatment for borderline personality disorder: a naturalistic study

BMC Psychiatry, 2018
Background Mentalisation-based treatment (MBT) in borderline personality disorder (BPD) has a growing evidence base, but there is a lack of effectiveness and moderator studies. The present study examined the effectiveness of MBT in a naturalistic setting
J. Löf, D. Clinton, V. Kaldo, G. Rydén
doaj   +1 more source

150 Envisioning a Multi-Site Translational Studio to Promote Scientific Integrity and Ethical Innovation

Journal of Clinical and Translational Science
OBJECTIVES/GOALS: The goal of this study is to develop a multi-centered Translational Studio model that can help in the development of quality translational studies using resources from four different institutional partners (University of Texas Medical ...
Emma Tumilty, Elise Smith, Alison Zill, Veronica Ajewole, Omonike A. Olaleye, Ivy Poon, Mary Short, Kathy Vincent   +7 more
doaj   +1 more source

Early switch from intravenous to oral antibiotic therapy in patients with cancer who have low-risk neutropenic sepsis: the EASI-SWITCH RCT

Health Technology Assessment
Background Neutropenic sepsis is a common complication of systemic anticancer treatment. There is variation in practice in timing of switch to oral antibiotics after commencement of empirical intravenous antibiotic therapy.
Vicky Coyle, Caroline Forde, Richard Adams, Ashley Agus, Rosemary Barnes, Ian Chau, Mike Clarke, Annmarie Doran, Margaret Grayson, Danny McAuley, Cliona McDowell, Glenn Phair, Ruth Plummer, Dawn Storey, Anne Thomas, Richard Wilson, Ronan McMullan   +16 more
doaj   +1 more source