Exploiting the potential of large databases of electronic health records for research using rapid search algorithms and an intuitive query interface. [PDF]
, 2013 Objective: UK primary care databases, which contain diagnostic, demographic and prescribing information for millions of patients geographically representative of the UK, represent a significant resource for health services and clinical research. They can
Al-Radwan, Balques +7 more
core +1 more source
The implausibility of ‘usual care’ in an open system: sedation and weaning practices in Paediatric Intensive Care Units (PICUs) in the United Kingdom (UK) [PDF]
, 2015 Background: The power of the randomised controlled trial depends upon its capacity to operate in a closed system whereby the intervention is the only causal force acting upon the experimental group and absent in the control group, permitting a valid ...
B Ambuel +34 more
core +1 more source
A Randomized Controlled Trial of a Play-Based, Peer-Mediated Pragmatic Language Intervention for Children With Autism [PDF]
, 2019 Purpose: This randomized controlled trial evaluated the effectiveness of a play-based pragmatic language intervention for children with autism. Methods: A sample of 71 children with autism were randomized to an intervention-first group (n = 28 analyzed ...
Cordier, Reinie +3 more
core +3 more sources
Larval therapy for leg ulcers (VenUS II) : randomised controlled trial [PDF]
, 2009 Objective To compare the clinical effectiveness of larval therapy with a standard debridement technique (hydrogel) for sloughy or necrotic leg ulcers. Design Pragmatic, three armed randomised controlled trial.
Bland, J. Martin +10 more
core +3 more sources
Challenges in evaluating surgical innovation [PDF]
, 2009 Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Blazeby, Jane M +6 more
core +1 more source
Systematic case study research : a practice-oriented introduction to building an evidence base for counselling and psychotherapy [PDF]
, 2011 Background: Historically, clinical case studies have played a central role in counselling and psychotherapy training and practice, by allowing practitioners to learn about ideas and interventions being developed by colleagues.
Elliott, Robert, McLeod, John
core +1 more source
FIRE (facilitating implementation of research evidence) : a study protocol [PDF]
, 2012 Research evidence underpins best practice, but is not always used in healthcare. The Promoting Action on Research Implementation in Health Services (PARIHS) framework suggests that the nature of evidence, the context in which it is used, and whether ...
A Donner +68 more
core +7 more sources
Cochrane acute respiratory infections group's stakeholder engagement project identified systematic review priority areas [PDF]
, 2018 Objective: Cochrane acute respiratory infections (ARIs) group conducts systematic reviews of the evidence for treatment and prevention of ARIs. We report the results of a prioritization project, aiming to identify highest priority systematic review ...
Clark, Justin +5 more
core +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Effect of a Clinical Evidence Technology on Patient Skin Disease Outcomes in Primary Care: A Cluster-Randomized Controlled Trial [PDF]
, 2018 Objective: Providers’ use of clinical evidence technologies (CETs) improves their diagnosis and treatment decisions. Despite these benefits, few studies have evaluated the impact of CETs on patient outcomes. Investigators evaluated the effect of one CET,
Burke, Marianne +1 more
core +1 more source