Results 91 to 100 of about 1,040,233 (268)
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin +7 more
wiley +1 more source
Konvergenzbezogene Medienaneignung in Kindheit und Jugend
Die konvergente Medienwelt ist selbstverständlich in den Medienalltag von Kindern und noch mehr von Jugendlichen integriert. Diese Integration beginnt in früher Kindheit, wenn die Produkte crossmedialer Vermarktung als Medienprodukte, Spielzeug oder ...
Ulrike Wagner, Helga Theunert
doaj +1 more source
Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan +14 more
wiley +1 more source
Supporting Water Governance and Climate Change Adaptation Through Systemic Praxis [PDF]
Understanding and working with multiple perspectives on issues of change is an essential part of managing “common pool” water resources. In uncertain and complex situations arising from changes in human settlements and climate, both lives and livelihoods
Blackmore, Chris +2 more
core
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr +5 more
wiley +1 more source
The present study explores the impact of earnings management on the readability of management discussion and analysis (MDA) section of annual reports of 384 Indian firms for 1,160 firm-years.
Sweta Tiwari +2 more
doaj +1 more source
Abstract Objective Focal cortical dysplasia (FCD) causes drug‐resistant epilepsy requiring presurgical evaluation. Invasive electroencephalographic (EEG) studies demonstrate that sleep modulates epileptic activity, including interictal epileptiform discharges (IEDs), fast oscillations (FOs) in the beta (14–40 Hz) and gamma (40–80 Hz) frequency bands ...
Marcel Heers +13 more
wiley +1 more source
Engagement of People With Lived Experience in Spinal Cord Injury to Address Innovation Priorities
Introduction The involvement of people with lived experience (PLEX) of spinal cord injury (SCI) is not common during medical innovation design, research and commercialization processes.
Julia T. Ross +10 more
doaj +1 more source

