Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment [PDF]
PLoS Neglected Tropical Diseases, 2014 Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities.
Poppy H L Lamberton, Joanne P Webster
exaly +40 more sources
Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial. [PDF]
PLoS Neglected Tropical Diseases, 2014 Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis.
Jennifer Keiser +6 more
doaj +7 more sources
Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]
PLoS Neglected Tropical Diseases, 2016 BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda +5 more
doaj +6 more sources
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand
Nature Communications, 2017 Schistosomiasis is caused by infection with the flatworm Schistosoma, and praziquantel is the drug of choice for its treatment. Here, Chan and colleagues identify praziquantel as a ligand for the human serotoninergic 5-HT2B G-protein-coupled receptor ...
John D Chan +2 more
exaly +2 more sources
Effects of praziquantel on early life stages of Grass carp, Ctenopharyngodon idella [PDF]
Veterinární MedicínaThis study aimed to assess the toxicity of the anthelmintic drug praziquantel in the early life stages of grass carp (Ctenopharyngodon idella). The toxicity was evaluated based on mortality, early ontogeny development, growth, oxidative stress biomarkers,
J Velisek +5 more
doaj +2 more sources
Praziquantel in clonorchiasis and opisthorchiasis [PDF]
Tropenmedizin und Parasitologie, 1981 A single stool examination revealed pathogenic intestinal parasites in 462 (58%) of 796 vietnamese and cambodian refugees. 56 (7.0%) were infected with Clonorchis sinensis and/or Opisthorchis viverrini. These patients received Praziquantel in a dosage of
Lang, W. +4 more
core +3 more sources
Seizures and Praziquantel. A case report [PDF]
Revista do Instituto de Medicina Tropical de São Paulo, 1988 A 27 year Old male developed seizures after receiving a single 20 mg/kg dose of praziquantel for the treatment of an intestinal Hymenolepis nana infection. On further clinical and laboratorial evaluations, he was found to suffer from an until then asymptomatic parenchymal brain cysticercosis.
Jaime R. Torres R. +3 more
openalex +7 more sources
The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni [PDF]
, 2016 Natural selection acts on all organisms, including parasites, to maximise reproductive fitness. Drug resistance traits are often associated with life-history costs in the absence of treatment.
Viana, Mafalda +4 more
core +13 more sources
Optimal single sampling time-point for monitoring of praziquantel exposure in children
Scientific Reports, 2021 Praziquantel pharmacokinetics studies in schistosomiasis infected children are scarce partly due to the challenges/complexity of intensive blood sampling in the target population. This study was aimed to investigate the optimal single sampling time-point
Rajabu Hussein Mnkugwe +5 more
doaj +1 more source
Chromatographic Quantification of Ivermectin and Pranziquantel in the Tablets Using Stability Indicating RP-HPLC Method [PDF]
Pharmaceutical Sciences, 2019 Background: A new stability indicating RP-HPLC based assay method was developed to quantify ivermectin and praziquantel simultaneously and applied effectively to tablets.
Naga Venkata Suresh Kumar Devaka +1 more
doaj +1 more source