Results 11 to 20 of about 30,204 (224)

Praziquantel sensitivity of Kenyan Schistosoma mansoni isolates and the generation of a laboratory strain with reduced susceptibility to the drug

International Journal for Parasitology: Drugs and Drug Resistance, 2014
Schistosomiasis is a neglected tropical disease caused by blood-dwelling flukes of the genus Schistosoma. While the disease may affect as many as 249 million people, treatment largely relies on a single drug, praziquantel.
Ibrahim N. Mwangi, Melissa C. Sanchez, Gerald M. Mkoji, Lelo E. Agola, Steven M. Runo, Pauline M. Cupit, Charles Cunningham   +6 more
doaj   +2 more sources

Efficacy of Praziquantel for the Treatment of Human Schistosomiasis in Ethiopia: A Systematic Review and Meta-Analysis

Journal of Tropical Medicine, 2021
Background. Schistosomiasis is one of the neglected tropical diseases causing a serious human health problem in Ethiopia. Praziquantel is the only drug that has been used for the treatment of human schistosomiasis in the country.
Tamirat Hailegebriel, Endalkachew Nibret, Abaineh Munshea   +2 more
doaj   +2 more sources

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial. [PDF]

PLoS Neglected Tropical Diseases, 2016
BACKGROUND:Schistosomiasis affects millions of people, yet treatment options are limited. The antimalarial Synriam (piperaquine 150 mg/arterolane 750 mg) and the anthelminthic moxidectin revealed promising antischistosomal properties in preclinical or ...
Beatrice Barda, Jean T Coulibaly, Maxim Puchkov, Jörg Huwyler, Jan Hattendorf, Jennifer Keiser   +5 more
doaj   +6 more sources

Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni

Parasites & Vectors, 2020
Background The control of schistosomiasis has been centered to date on a single drug, praziquantel, with shortcomings including treatment failure, reinfection, and emergence of drug resistance. Drug repurposing, combination therapy or nanotechnology were
Maha M. Eissa, Mervat Z. El-Azzouni, Labiba K. El-Khordagui, Amany Abdel Bary, Riham M. El-Moslemany, Sara A. Abdel Salam   +5 more
doaj   +2 more sources

The effects of subcurative praziquantel treatment on life‐history traits and trade‐offs in drug‐resistant Schistosoma mansoni [PDF]

Evolutionary Applications, 2018
Natural selection acts on all organisms, including parasites, to maximize reproductive fitness. Drug resistance traits are often associated with life‐history costs in the absence of treatment.
Mafalda Viana, Christina L. Faust, Daniel T. Haydon, Joanne P. Webster, Poppy H. L. Lamberton   +4 more
doaj   +15 more sources

Sensitivity and Specificity of Multiple Kato-Katz Thick Smears and a Circulating Cathodic Antigen Test for Schistosoma mansoni Diagnosis Pre- and Post-repeated-Praziquantel Treatment [PDF]

, 2014
Two Kato-Katz thick smears (Kato-Katzs) from a single stool are currently recommended for diagnosing Schistosoma mansoni infections to map areas for intervention. This ‘gold standard’ has low sensitivity at low infection intensities.
A Koukounari, A Koukounari, Alan Fenwick, AP Plaisier, B Erko, BJ Vennervald, CD Criscione, CJ Standley, CM Gower, D De Clercq, D Engels, D Rollinson, David W. Oguttu, DD Lin, DG Colley, HL Shane, IM Cesari, J Utzinger, J Utzinger, J Utzinger, Joanne P. Webster, JP Webster, JR Landis, JR Stothard, JR Stothard, JS Kim, JT Coulibaly, JT Coulibaly, K Stete, L van Lieshout, L van Lieshout, LA Tchuem Tchuenté, LI Gomes, LM Siqueira, M Adriko, M Albonico, M Booth, MD French, MJ Enk, N Katz, Narcis B. Kabatereine, NB Kabatereine, PHL Lamberton, PJ Hotez, Poppy H. L. Lamberton, R Bergquist, R Grenfell, RA Ashton, RF Grenfell, RF Grenfell, S Brooker, S Knopp, S Knopp, S Knopp, SM da Frota, Stefanie Knopp, Y Zhang   +56 more
core   +39 more sources

Efficacy and safety of praziquantel and dihydroartemisinin piperaquine combination for treatment and control of intestinal schistosomiasis: A randomized, non-inferiority clinical trial.

PLoS Neglected Tropical Diseases, 2020
BackgroundDespite the reported success in reducing morbidity, praziquantel alone is insufficient for the control and elimination of schistosomiasis, partly due to its poor efficacy against the juvenile worms. Artemisinin derivatives are effective against
Rajabu Hussein Mnkugwe, Omary Minzi, Safari Kinung'hi, Appolinary Kamuhabwa, Eleni Aklillu   +4 more
doaj   +2 more sources

Two-year longitudinal survey reveals high genetic diversity of Schistosoma mansoni with adult worms surviving praziquantel treatment at the start of mass drug administration in Uganda

Parasites & Vectors, 2019
Background A key component of schistosomiasis control is mass drug administration with praziquantel. While control interventions have been successful in several endemic regions, mass drug administration has been less effective in others. Here we focus on
Christina L. Faust, Marco Crotti, Arinaitwe Moses, David Oguttu, Aidah Wamboko, Moses Adriko, Elizabeth K. Adekanle, Narcis Kabatereine, Edridah M. Tukahebwa, Alice J. Norton, Charlotte M. Gower, Joanne P. Webster, Poppy H. L. Lamberton   +12 more
doaj   +2 more sources

Ground Calcium Carbonate as a Low Cost and Biosafety Excipient for Solubility and Dissolution Improvement of Praziquantel

Pharmaceutics, 2019
Calcium carbonate is an abundant mineral with several advantages to be a successful carrier to improve oral bioavailability of poorly water-soluble drugs, such as praziquantel.
Ana Borrego-Sánchez, Rita Sánchez-Espejo, Beatrice Albertini, Nadia Passerini, Pilar Cerezo, César Viseras, C. Ignacio Sainz-Díaz   +6 more
doaj   +2 more sources

Efficacy and Safety of Praziquantel for Treatment of Schistosoma mansoni Infection among School Children in Tanzania

Pathogens, 2019
Single-dose targeted praziquantel preventive chemotherapy is the WHO-recommended intervention for schistosomiasis control in endemic countries.
Rajabu Hussein Mnkugwe, Omary S. Minzi, Safari M. Kinung’hi, Appolinary A. Kamuhabwa, Eleni Aklillu   +4 more
doaj   +2 more sources