Results 31 to 40 of about 37,525 (284)

Efficacy of praziquantel has been maintained over four decades (from 1977 to 2018): A systematic review and meta-analysis of factors influence its efficacy

PLoS Neglected Tropical Diseases, 2021
Background The antihelminthic drug praziquantel has been used as the drug of choice for treating schistosome infection for more than 40 years. Although some epidemiological studies have reported low praziquantel efficacy in cure rate (CR) and/or egg ...
M. Fukushige, M. Chase-Topping, M. Woolhouse, F. Mutapi   +3 more
semanticscholar   +1 more source

Cocrystals of Praziquantel: Discovery by Network-Based Link Prediction

Crystal Growth & Design, 2021
Cocrystallization has been promoted as an attractive early development tool as it can change the physicochemical properties of a target compound and possibly enable the purification of single enantiomers from racemic compounds.
J. Devogelaer, Maxime D. Charpentier, Arnoud Tijink, V. Dupray, G. Coquerel, K. Johnston, H. Meekes, P. Tinnemans, E. Vlieg, J. T. ter Horst, R. de Gelder   +10 more
semanticscholar   +1 more source

Uptake of preventive treatment for intestinal schistosomiasis among school children in Jinja district, Uganda: a cross sectional study. [PDF]

PLoS ONE, 2013
BACKGROUND: In Uganda, the current national health sector strategic and investment plan underscores schistosomiasis as one of the diseases targeted for elimination by the year 2015.
Simon Muhumuza, Annette Olsen, Anne Katahoire, Fred Nuwaha   +3 more
doaj   +1 more source

Potential cost-effectiveness of schistosomiasis treatment for reducing HIV transmission in Africa--the case of Zimbabwean women. [PDF]

PLoS Neglected Tropical Diseases, 2013
Epidemiological data from Zimbabwe suggests that genital infection with Schistosoma haematobium may increase the risk of HIV infection in young women. Therefore, the treatment of Schistosoma haematobium with praziquantel could be a potential strategy for
Martial L Ndeffo Mbah, Eric M Poolman, Katherine E Atkins, Evan W Orenstein, Lauren Ancel Meyers, Jeffrey P Townsend, Alison P Galvani   +6 more
doaj   +1 more source

Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel

Parasite, 2021
Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard® Combo, a novel topical endectoparasiticide formulation for cats.
Virginie Jacquot, Prescillia Buellet, L. Letendre, W. Tong, Henry Li, E. Tielemans   +5 more
semanticscholar   +1 more source

Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery

Pharmaceutics, 2023
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients.
Giselle Bedogni, Paula Garcia, Katia Seremeta, Nora Okulik, Claudio Salomon   +4 more
doaj   +1 more source

Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel

Brazilian Journal of Pharmaceutical Sciences, 2010
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility.
Marco Vinicius Chaud, Pollyanna Tamascia, Andréa Cristina de Lima, Maria Ondina Paganelli, Maria Palmira Daflon Gremião, Osvaldo de Freitas   +5 more
doaj   +1 more source

The study of base and surface-active substances influence on biopharmaceutical characteristics of suppository with praziquantel

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016
Acne dermatoses (rosacea, perioral dermatitis, seborrheic dermatitis etc.) are one of the most actual problems in dermatology. Praziquantel is an antiparasitic medication effective towards trematodes, cestodes.
D. M. Romanina, V. V. Gladishev, G. P. Lisyanska   +2 more
doaj   +1 more source

Study of influence of the surface-active substances concentration on releasing of praziquantel from the rectal suppository

Фармацевтичний журнал, 2018
Acne dermatosis (rosacea, perioral dermatitis, seborrheic dermatitis etc.) are one of the most actual problem in dermatology. Praziquantel is an antiparasitic medication effective towards trematodes, cestodes.
D. M. Romanina, I. I. Berdey, V. V. Gladishev, G. P. Lisyanska   +3 more
doaj   +1 more source

Alternatives to Praziquantel for the Prevention and Control of Schistosomiasis.

ACS Infectious Diseases, 2020
Schistosomiasis, a neglected tropical disease provoked by infection with parasitic blood flukes of the genus Schistosoma, affects almost 240 million people worldwide, and more than 700 million people live in endemic areas.
T. Spangenberg
semanticscholar   +1 more source