Results 31 to 40 of about 30,204 (224)

The Role of Praziquantel in the Prevention and Treatment of Fibrosis Associated with Schistosomiasis: A Review

Journal of Tropical Medicine, 2022
Schistosomiasis remains a major global public health concern. Currently, the control of this neglected tropical disease still depends on chemotherapy to reduce the prevalence and intensity of the parasite infection.
X. Niu, Tao Hu, Yeonwoo Hong, Xiaoyan Li, Yu-min P Shen   +4 more
semanticscholar   +1 more source

Praziquantel-encapsulated niosomes against Schistosoma mansoni with reduced sensitivity to praziquantel

Biomedica : revista del Instituto Nacional de Salud, 2022
Introduction: Praziquantel (PZQ) is the only commercially available drug for schistosomiasis. The current shortage of alternative effective drugs and the lack of successful preventive measures enhance its value.
E. I. Amer, I. Abou-El-Naga, L. Boulos, H. Ramadan, Salwa S Younis   +4 more
semanticscholar   +1 more source

Potential cost-effectiveness of schistosomiasis treatment for reducing HIV transmission in Africa--the case of Zimbabwean women. [PDF]

PLoS Neglected Tropical Diseases, 2013
Epidemiological data from Zimbabwe suggests that genital infection with Schistosoma haematobium may increase the risk of HIV infection in young women. Therefore, the treatment of Schistosoma haematobium with praziquantel could be a potential strategy for
Martial L Ndeffo Mbah, Eric M Poolman, Katherine E Atkins, Evan W Orenstein, Lauren Ancel Meyers, Jeffrey P Townsend, Alison P Galvani   +6 more
doaj   +1 more source

Uptake of preventive treatment for intestinal schistosomiasis among school children in Jinja district, Uganda: a cross sectional study. [PDF]

PLoS ONE, 2013
BACKGROUND: In Uganda, the current national health sector strategic and investment plan underscores schistosomiasis as one of the diseases targeted for elimination by the year 2015.
Simon Muhumuza, Annette Olsen, Anne Katahoire, Fred Nuwaha   +3 more
doaj   +1 more source

Cocrystals of Praziquantel: Discovery by Network-Based Link Prediction

Crystal Growth & Design, 2021
Cocrystallization has been promoted as an attractive early development tool as it can change the physicochemical properties of a target compound and possibly enable the purification of single enantiomers from racemic compounds.
J. Devogelaer, Maxime D. Charpentier, Arnoud Tijink, V. Dupray, G. Coquerel, K. Johnston, H. Meekes, P. Tinnemans, E. Vlieg, Joop H. ter Horst, R. de Gelder   +10 more
semanticscholar   +1 more source

Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery

Pharmaceutics, 2023
To date, the treatment for cysticercosis and neurocysticercosis consists of a single oral intake of praziquantel (5–10 mg/kg), which since it is only available as tablets, hinders its administration to pediatric patients.
Giselle Bedogni, Paula Garcia, Katia Seremeta, Nora Okulik, Claudio Salomon   +4 more
doaj   +1 more source

Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel

Parasite, 2021
Esafoxolaner, a purified enantiomer of afoxolaner with insecticidal and acaricidal properties, is combined with eprinomectin and praziquantel in NexGard® Combo, a novel topical endectoparasiticide formulation for cats.
Virginie Jacquot, Prescillia Buellet, L. Letendre, W. Tong, Henry Li, E. Tielemans   +5 more
semanticscholar   +1 more source

Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel

Brazilian Journal of Pharmaceutical Sciences, 2010
The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid Dispersion (SD) has tremendous potential for improving drug solubility.
Marco Vinicius Chaud, Pollyanna Tamascia, Andréa Cristina de Lima, Maria Ondina Paganelli, Maria Palmira Daflon Gremião, Osvaldo de Freitas   +5 more
doaj   +1 more source

New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel [PDF]

, 2015
By 2020, the global health community aims to control and eliminate human helminthiases, including schistosomiasis in selected African countries, principally by preventive chemotherapy (PCT) through mass drug administration (MDA) of anthelminthics ...
A Danso-Appiah, A Fenwick, A Montresor, A Vidyashankar, AC Gelman, AE Butterworth, AL Bustinduy, Alexandra U. Scherrer, AU Scherrer, B Levecke, BM Bolker, CH King, Charles H. King, CJL Murray, CL Black, D Alonso, D Bates, F Thiongo, G Raso, Giovanna Raso, GR Olds, IM Silva, J Cabaret, J Modha, J Smith, J Utzinger, J Utzinger, J Utzinger, J. Russell Stothard, JA Hanley, JC Sousa-Figueiredo, JD Hadfield, Jean T. Coulibaly, José Carlos Sousa-Figueiredo, JP Webster, JT Coulibaly, Jürg Utzinger, K Stete, Katarina Stete, M Albonico, M Booth, M Ismail, M Nielsen, M Reddy, M Walker, Maria-Gloria Basáñez, Martin Walker, ME Mejía, MEJ Woolhouse, MG Basáñez, MJ Bockarie, MJ Doenhoff, MJ Doenhoff, P Andrews, P Fallon, PH Lamberton, Piero L. Olliaro, PJ Brindley, PJ Diggle, PJ Hotez, PL Olliaro, PNM Mwinzi, R Core Team, S Anayi, SD Melman, SJ Vlas de, SN Lahiri, SV Subramanian, Tarub S. Mabud, TW Jia, U Halekoh, W Harnett, W Wang, World Health Organization, World Health Organization, World Health Organization   +75 more
core   +4 more sources

Praziquantel coverage in schools and communities targeted for the elimination of urogenital schistosomiasis in Zanzibar: a cross-sectional survey [PDF]

, 2015
© 2015 Knopp et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any ...
Ali, SM, Ame, SM, Blair, L, Fenwick, A, Juma, S, Khamis, IS, Knopp, S, Mohammed, KA, Muhsin, J, Person, B, Rabone, M, Rollinson, D   +11 more
core   +2 more sources