Results 91 to 100 of about 28,463 (245)

Electrochemical Hofmann Rearrangement for Modular Synthesis of Unsymmetrical Ureas and Late‐Stage Modification of Drugs

Advanced Science, Volume 13, Issue 31, 4 June 2026.
An electrochemical Hofmann rearrangement of amide involving amine or other amide nucleophiles has been developed. The use of NaI guarantees the feasibility and compatibility of the electrosynthesis protocol, which enables highly chemoselective synthesis of unsymmetrical N‐acylureas from two different amides, as well as the production of unsymmetrical ...
Xue‐Qing Mou, Xiao Zha, Yu‐Rui Jian, Shao‐Xing Zhong, Xin‐Yu Fu, Sheng‐Yang Xu, Wei Xiang, Bao‐Dong Cui, Yun Zhang, Yong‐Zheng Chen   +9 more
wiley   +1 more source

The development of type 2 diabetes amongst sibling pairs in the South‐South region of Nigeria: The effect of genetics, environment and lifestyle

Diabetic Medicine, Volume 43, Issue 6, June 2026.
Abstract Introduction Type 2 diabetes is a complex condition with a multifactorial pathogenesis. The pathogenesis is considered to be polygenic due to complex interactions between genetic/epigenetic and environmental factors. The aim of this study is to determine the genetic, environmental and lifestyle factors associated with the development of type 2
Sunny Chinenye, Ibi Erekosima, Adrian H. Heald, Gesiye Bozimo, Simon G. Anderson, Samuel Seidu, Kariba Akhidue, Adaeze Ugwu, Chioma Unachukwu, Ibitrokoemi Korubo, Kingsley Chukwuemeka Patrick‐Iwuanyanwu, Victoria Gomba, Uwoma Batubo, Victoria Akanatei, Victor Ken‐Uba, Iyeopu Siminialayi, Sokiprim Akoko, Justin Ideozu, Hamilton Opurum   +18 more
wiley   +1 more source

Retrospective study of outcome in patients with scorpion sting using prazosin with/without dobutamine

Asian Journal of Medical Sciences, 2015
Introduction: Scorpion sting is a major public health problem in India with severe life threatening complications. Toxin can cause autonomic overstimulation leading to hypertension, arrhythmias and pulmonary edema with left ventricular dysfunction ...
L Venugopal
doaj   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Prazosin and cyclazosin induce ERK1/2 phosphorylation. [PDF]

, 2018
HEK293 cells transfected with CXCR4 (A/B) or ACKR3 (C/D) were stimulated with CXCL12 (100 nM), prazosin (100 μM) or cyclazosin (100 μM) for various time periods as indicated.
Hazem Abdelkarim (1883086), Vadim Gaponenko (1883077), Lauren J. Albee (5782589), Matthias Majetschak (2848619), Xianlong Gao (3746263), Brian F. Volkman (502457)   +5 more
core   +1 more source

STING Activation in Dendritic Cells Enhances Antigen Presentation by Live Tumor Cells

European Journal of Immunology, Volume 56, Issue 5, May 2026.
Our study reveals that STING activation in dendritic cells using cGAMP‐VLP enhances CD8+ T cell recognition of live tumor cells by inducing type I interferon‐dependent upregulation of MHC‐I on tumor cells in vitro. In vivo, cGAMP‐VLP boosts antitumor immunity even in cGAS‐deficient tumors, thereby improving the efficacy of immune checkpoint blockade ...
Adriana Loverre, Bakhos Jneid, Magali Genest, Maries van den Broek, Nicolas Manel   +4 more
wiley   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Propranolol and Prazosin Have a Positive Effect on the Sexual Performance of Female Three-Spot Gourami [PDF]

Journal of Kerman University of Medical Sciences
Background: Sexual function is one of the most important aspects of life and is likely to be affected by the side effects of antihypertensive drugs. This study aimed to evaluate the effect of propranolol and prazosin on the sexual performance of female ...
Marzieh Monemi, Tahereh Naji, Afshin Kheradmand   +2 more
doaj   +1 more source

Regulation mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling

Di-san junyi daxue xuebao, 2020
Objective To elucidate the important role and molecular mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling. Methods ① Eight-week-old male spontaneously hypertensive rats (SHRs) were randomly divided into losartan group [gavage with ...
ZHANG Wenqian, WANG Qiaozhu, SHI Peifei, FENG Yanjing, GAO Dengfeng, LIU Xin   +5 more
doaj   +1 more source

Amino Acids of the Human α 1d-Adrenergic Receptor Involved in Antagonist Binding

Journal of Pharmacological Sciences, 2008
Computer simulations of the human α 1d-adrenergic receptor (α 1d-AR) based on the crystal structure of rhodopsin have been combined with experimental site-directed mutagenesis to investigate the role of residues in the transmembrane domains in antagonist
Yuko Nagaoka, Maruf Ahmed, Murad Hossain, Mohiuddin Ahmed Bhuiyan, Masaji Ishiguro, Takashi Nakamura, Masatomo Watanabe, Takafumi Nagatomo   +7 more
doaj   +1 more source