Results 91 to 100 of about 19,342 (211)
Regulation mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling
Di-san junyi daxue xuebao, 2020 Objective To elucidate the important role and molecular mechanism of AT1R/miR-26a pathway in hypertensive vascular remodeling. Methods ① Eight-week-old male spontaneously hypertensive rats (SHRs) were randomly divided into losartan group [gavage with ...
ZHANG Wenqian +5 more
doaj +1 more source
State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. [PDF]
, 2019 Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition ...
Garcia-Junco-Clemente, Pablo +3 more
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Amino Acids of the Human α 1d-Adrenergic Receptor Involved in Antagonist Binding
Journal of Pharmacological Sciences, 2008 Computer simulations of the human α 1d-adrenergic receptor (α 1d-AR) based on the crystal structure of rhodopsin have been combined with experimental site-directed mutagenesis to investigate the role of residues in the transmembrane domains in antagonist
Yuko Nagaoka +7 more
doaj +1 more source
Distribution and density of α- and β-adrenergic receptor binding sites in the bovine mammary gland [PDF]
, 2017 Radioreceptor binding studies were designed to localize and determine the number of α and β-adrenergic receptors in the mammary gland of lactating cows.
Blum, Jürg W. +3 more
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Prazosin Effects on Clinical Symptoms in Combat Related Post Traumatic Stress Disorder
طب جانباز, 2011 Objective : This study effects of prazosin on the clinical symptoms of chronic combat related posttraumatic stress disorder, into the cases of chronic disorder Methods: The study group of one type of intervention before and after sampling and testing is
M.R. khodaii ardekani +4 more
doaj
Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter
Frontiers in Pharmacology, 2015 The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously ...
Darren eMoss +3 more
doaj +1 more source
Clinics, 2013 OBJECTIVE: In the present study, the peripheral mechanism that mediates the pressor effect of angiotensin-(1-7) in the rostral ventrolateral medulla was investigated.
Rita C. Oliveira +2 more
doaj
A review of the long-term effects of prazosin and hydralazine in chronic congestive heart failure [PDF]
, 2017 In the last two years, six studies using prazosin in doses of 3-32 mg/day for two and 16 months have shown a persistent but variable benefit in 50-80% of those who initially responded favorably. However, serious side-effects occurred in up to 40% and, in
Rutishauser, W.
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Annals of MedicineObjective The current guidelines and canonical norms of diagnosis or treatment for Post-traumatic stress disorder (PTSD) with sleep disorder are still conflicting and have not yet reached a consensus.
Cheng-Yang Huang +8 more
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PTSD – an update for general practitioners [PDF]
Provides up-to-date guidance for general practitioners (GPs) in the recognition of PTSD and the current best practice recommendations for pharmacological and psychological treatment. Background Australians are commonly exposed to traumatic events, which
Andrea Phelps +2 more
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