Results 71 to 80 of about 28,463 (245)

Cerebrovascular flow‐mediated dilation in humans: Methodological challenges, physiological interpretation and future integrations

Experimental Physiology, EarlyView.
Abstract Arterial shear‐mediated vasodilation is a well‐established measure of endothelial function and serves as a critical biomarker for cardiovascular disease risk. Endothelial function can be measured using a variety of experimental methodologies; however, the most widely adopted technique is ultrasound‐based flow‐mediated dilation (FMD), in which ...
Yi Zhen Bao, Tabitha V. Craig, Jenna C. McCrone, Kurt J. Smith, Michael M. Tymko   +4 more
wiley   +1 more source

Optimizing Aggregated N-Of-1 Trial Designs for Predictive Biomarker Validation: Statistical Methods and Theoretical Findings

Frontiers in Digital Health, 2020
Background and Significance: Parallel-group randomized controlled trials (PG-RCTs) are the gold standard for detecting differences in mean improvement across treatment conditions.
Rebecca C. Hendrickson, Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Nicholas J. Schork, Murray A. Raskind, Murray A. Raskind   +6 more
doaj   +1 more source

Electronic medical records-based retrospective, longitudinal, observational study to understand the patient management of benign prostatic hyperplasia with alpha-blockers monotherapy in Indian population

Urology Annals, 2023
Objective: The present retrospective study evaluates the effectiveness and tolerability of alpha-blockers as monotherapy in patients with benign prostatic hyperplasia associated with lower urinary tract symptoms (LUTS).
Rahul Gupta, Sameer Trivedi, Surya Prakash Vaddi, Mrinal Borgohain, Rajan Mittal, Sucheta Pandit, Amey Mane   +6 more
doaj   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

Ejaculatory Dysfunction and Minimally Invasive Surgical Treatments (MIST) for Male Lower Urinary Tract Symptoms Secondary to Benign Prostatic Enlargement

Trends in Urology &Men's Health, Volume 17, Issue 4, August 2026.
ABSTRACT While transurethral resection of the prostate (TURP) is considered the standard surgical treatment in symptomatic benign prostatic enlargement (BPE) secondary to benign prostatic hyperplasia (BPH), it is not without surgical morbidities and has adverse impact on various sexual function domains such as ejaculatory dysfunction (EjD) and erectile
Haijun Yao, Tao Wang, Shan‐Chao Zhao, Lei Zheng, Rui Jiang, Han Wu, Jingjing Gao, Baibing Yang, Yuzhuo Yang, Haocheng Lin, Eric Chung   +10 more
wiley   +1 more source

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, Volume 38, Issue 8, Page 442-452, August 2026.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Use of Prazosin for Pediatric Post-Traumatic Stress Disorder With Nightmares and/or Sleep Disorder: Case Series of 18 Patients Prospectively Assessed

Frontiers in Psychiatry, 2020
ObjectivesFew studies have investigated pharmacologic treatment for pediatric post-traumatic stress disorder (PTSD). Prazosin, an alpha-1 adrenergic receptor antagonist, has been studied and demonstrated to be efficacious in an adult population for PTSD ...
Vladimir Ferrafiat, Vladimir Ferrafiat, Maryam Soleimani, Maryam Soleimani, Boris Chaumette, Audrey Martinez, Jean-Marc Guilé, Jean-Marc Guilé, Jean-Marc Guilé, Brooks Keeshin, Priscille Gerardin, Priscille Gerardin   +11 more
doaj   +1 more source

Prazosin use in a patient with rare Neurobeachin gene deletion shows improvement in paranoid behavior: a case report

Journal of Medical Case Reports, 2021
Background Disruption of the Neurobeachin gene is a rare genetic mutation that has been implicated in the development of autism and enhanced long-term potentiation of the hippocampal CA1 region, causing a heightened conditioned fear response and impaired
Christina Y. Cantwell, Jamie Fortman, Alexis Seegan   +2 more
doaj   +1 more source

Catecholamines Activate a Tumour Progression Program in Differentiated Tumour Hepatocytes

Liver International, Volume 46, Issue 8, August 2026.
ABSTRACT Background and Aims The sympathetic nervous system is involved in the progression and aggressiveness of several cancers, including hepatocellular carcinoma (HCC). However, the specific effects of sympathetic innervation and catecholamines on tumour hepatocyte behaviour remain poorly understood.
Elise Lelou, Claudine Rauch, Hélène Dubois‐Pot‐Schneider, Marjorie Dufresne, Abolfazl Zekri Yazdi, Maelle Guillout, Luis Cano, Lise Desquilles, Nicolas Nesseler, Marc Bourgeois, Claude Bendavid, Julie Massart, Orlando Musso, Anne Corlu, Caroline Aninat   +14 more
wiley   +1 more source

PRAZOSIN IN NEUROGENIC BLADDER DYSFUNCTION [PDF]

, 1981
The clinical effect of Prazosin, an alpha blocking agent, was studied in 18 patients with neurogenic bladder dysfunction. The patients consisted of 11 supranuclear and 7 infranuclear type according to the neurological examinations. The daily doses of 0.5-
北村, 温, 中山, 朝行, 服部, 孝道, 香村, 衡一, 浜, 年樹, 村上, 信乃, 山城, 豊, 安田, 耕作, 島崎, 淳   +8 more
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