Results 61 to 70 of about 19,342 (211)

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible. [PDF]

, 2016
Aim: Is modulation of skeletal muscle capillary supply by altering blood flow due to a presumptive shear stress response per se, or dependent on the vasodilator mechanism?
Audet, Audet, Babaei, Balon, Baum, Bongrazio, Boushel, Carmeliet, Chen, Chu, Cohen, Conway, Da Silva-Azevedo, Dedkov, Egginton, Egginton, Egginton, Egginton, Egginton, Egginton, Ferrara, Ferrara, Fleming, Frangos, Friebel, Gately, Gavin, Goettsch, Hanahan, Hansen-Smith, Hansen-Smith, Hargreaves, Hellsten, Hirai, Houston, Hudlická, Hudlická, Hudlická, Hudlická, Jahr, Kaley, Kamio, Kano, Klenotic, McDonald, Milkiewicz, Milkiewicz, Milkiewicz, Milkiewicz, Milkiewicz, Milkiewicz, Mujika, Murohara, Neufeld, Olenich, Olfert, Pahakis, Pearce, Prior, Reiser, Resnick, Rivilis, Rubanyi, Schrage, Smith, Snyder, Sun, Topper, Tornling, Torres, Trappe, Tsujii, Tyml, Uchida, Wagatsuma, Wagner, Wang, Wang, Williams, Williams, Williams, Wragg, Zakrzewicz, Zhang, Ziada   +84 more
core   +1 more source

Targeting the noradrenergic‐metabolic axis: A new strategy for sugar‐induced depression subtypes

British Journal of Pharmacology, Volume 183, Issue 9, Page 2099-2122, May 2026.
Abstract Background and Purpose Lifestyle is closely related to major depressive disorder (MDD). Given the growing focus on the impact of diet on mental health, this study examined how dietary habits affect the pathophysiology of MDD. Experimental Approach Health check‐up data were analysed. Mice received sucrose under chronic unpredictable mild stress
Takatoshi Sakata, Kazuo Kunisawa, Masaya Hasegawa, Yumiko Seto, Aoi Ogawa, Hitomi Kurahashi, Yasuko Yamamoto, Masao Takemura, Hidetoshi Matunami, Tomoya Sugai, Noriki Kutsumura, Kuniaki Saito, Toshitaka Nabeshima, Akihiro Mouri   +13 more
wiley   +1 more source

Use of Prazosin for Pediatric Post-Traumatic Stress Disorder With Nightmares and/or Sleep Disorder: Case Series of 18 Patients Prospectively Assessed

Frontiers in Psychiatry, 2020
ObjectivesFew studies have investigated pharmacologic treatment for pediatric post-traumatic stress disorder (PTSD). Prazosin, an alpha-1 adrenergic receptor antagonist, has been studied and demonstrated to be efficacious in an adult population for PTSD ...
Vladimir Ferrafiat, Vladimir Ferrafiat, Maryam Soleimani, Maryam Soleimani, Boris Chaumette, Audrey Martinez, Jean-Marc Guilé, Jean-Marc Guilé, Jean-Marc Guilé, Brooks Keeshin, Priscille Gerardin, Priscille Gerardin   +11 more
doaj   +1 more source

Prazosin use in a patient with rare Neurobeachin gene deletion shows improvement in paranoid behavior: a case report

Journal of Medical Case Reports, 2021
Background Disruption of the Neurobeachin gene is a rare genetic mutation that has been implicated in the development of autism and enhanced long-term potentiation of the hippocampal CA1 region, causing a heightened conditioned fear response and impaired
Christina Y. Cantwell, Jamie Fortman, Alexis Seegan   +2 more
doaj   +1 more source

Raised tone reveals ATP as a sympathetic neurotransmitter in the porcine mesenteric arterial bed [PDF]

, 2014
The relative importance of ATP as a functional sympathetic neurotransmitter in blood vessels has been shown to be increased when the level of preexisting vascular tone or pressure is increased, in studies carried out in rat mesenteric arteries.
A Saul, A Shatarat, Amjad Shatarat, B Bhattacharya, C Vial, CJ Lewis, DC Eikenburg, DD McGregor, DP Gitterman, EW Inscho, G Burnstock, G Burnstock, G Burnstock, G Burnstock, GJ Crane, GM Rubanyi, JA Roberts, JQ Kong, L Shaw, M Yeoh, MJ Mulvany, MM Swindle, MV Donoso, N Montano, NM Rummery, P Pakdeechote, RA North, RC Van, RE Roberts, SC Malpas, TJ Williams, V Ralevic, Vera Ralevic, William R. Dunn, Y Tabuchi   +34 more
core   +2 more sources

Hepatotoxicity Associated with Labetalol Use: A Case Report with Systematic Review and Disproportionality Analysis Using FAERS

The Journal of Clinical Pharmacology, Volume 66, Issue 4, April 2026.
Abstract Labetalol is widely prescribed as a first‐line antihypertensive in pregnancy; however, rare but potentially severe idiosyncratic hepatotoxicity has been reported, with a disproportionately strong reporting signal for liver injury relative to other β‐blockers.
Emma D. Hendriksen, Michael Rieder, Elizabeth Urbantke   +2 more
wiley   +1 more source

Comparison of alpha-2 agonist versus alpha-1 antagonist for post-traumatic stress disorder–associated nightmares in pediatric patients [PDF]

Mental Health Clinician
Introduction Posttraumatic stress disorder (PTSD) in children and adolescents has a high prevalence of accompanying sleep disturbances. Currently, pediatric treatment of PTSD-related nightmares is extrapolated from adult studies.
Seher Khalid, PharmD, Sandra Mitchell, PharmD, BCPP, Cheryl Al-Mateen, MD, FAACAP, DFAPA   +2 more
doaj   +1 more source

Concomitant medication use and clinical outcome of repetitive Transcranial Magnetic Stimulation (rTMS) treatment of Major Depressive Disorder. [PDF]

, 2019
BackgroundRepetitive Transcranial Magnetic Stimulation (rTMS) is commonly administered to Major Depressive Disorder (MDD) patients taking psychotropic medications, yet the effects on treatment outcomes remain unknown.
Chawla, Shweta A, Cook, Ian A, Hunter, Aimee M, Krantz, David E, Leuchter, Andrew F, Levitt, Jennifer G, Minzenberg, Michael J, Rotstein, Natalie M   +7 more
core   +1 more source

The GPCR Connection: Linking Alzheimer's Disease and Glioblastoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.
ABSTRACT Alzheimer's disease (AD) and glioblastoma multiforme (GBM) are biologically distinct age‐related brain disorders with opposing clinical phenotypes. AD is characterised by progressive neurodegeneration and cognitive decline, whereas GBM is characterised by aggressive cellular proliferation and a poor prognosis.
Ana B. Caniceiro, Sofia P. Agostinho, Luiz F. Piochi, Nícia Rosário‐Ferreira, Irina S. Moreira   +4 more
wiley   +1 more source